Hypocretin deficiency develops during onset of human narcolepsy with cataplexy

TY - JOUR

T1 - Hypocretin deficiency develops during onset of human narcolepsy with cataplexy

AU - Savvidou, Andri

AU - Knudsen, Stine

AU - Olsson-Engman, Mia

AU - Gammeltoft, Steen

AU - Jennum, Poul

AU - Palm, Lars

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml). Conclusions: We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.

AB - Study Objectives: Although hypothesized through animal studies, a temporal and causal association between hypocretin deficiency and the onset of narcolepsy with cataplexy (NC) has never been proven in humans. Setting: Paediatric Department, Blekinge Hospital, Sweden, and Danish Center for Sleep Medicine, Glostrup Hospital, Denmark. Patient and Results: Two weeks after his second Pandemrix-vaccination, a 10 year old HLA-DQB1*0602-positive boy developed NC. The CSF hypocretin-1 level was 10 pg/ml. However, CSF saved from a pre-narcolepsy episode of Lyme disease revealed a normal hypocretin-1 level (318 pg/ml). Conclusions: We confirm that hypocretin deficiency develops in parallel to the onset of human narcolepsy with cataplexy.

U2 - 10.5665/sleep.2320

DO - 10.5665/sleep.2320

M3 - Journal article

C2 - 23288981

SN - 0161-8105

VL - 36

SP - 147

EP - 148

JO - Sleep (Online)

JF - Sleep (Online)

IS - 1

ER -