Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention

Nadia Paarup Dridi; Jacob T Lønborg; Maria D Radu; Peter Clemmensen; Thomas Engstrøm; Henning Kelbæk; Erik Jørgensen; Steffen Helqvist; Kari Saunamäki; Troels H Christensen; Florian M M Baeres; Pär I Johansson; Lene Holmvang

doi:10.1177/1076029613485411

Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention

Nadia Paarup Dridi, Jacob T Lønborg, Maria D Radu, Peter Clemmensen, Thomas Engstrøm, Henning Kelbæk, Erik Jørgensen, Steffen Helqvist, Kari Saunamäki, Troels H Christensen, Florian M M Baeres, Pär I Johansson, Lene Holmvang

Department of Clinical Medicine

1 Citation (Scopus)

Abstract

OBJECTIVES: We investigated the relationship between coagulation assessed by thromboelastography (TEG) and myocardial damage in ST-segment elevation myocardial infarction (STEMI).

METHODS: We measured platelet activity with TEG-maximum amplitude (TEG-MA) in 233 patients undergoing urgent percutaneous coronary intervention (PCI). Infarct size and myocardial salvage index were evaluated using cardiac magnetic resonance, and the relation of these parameters to posttreatment coagulation was examined retrospectively. Adverse events were adjudicated and related to the coagulation status during the index event.

RESULTS: Hypercoagulation was found in 82 (35.2%) patients and was neither correlated to infarct size nor correlated to myocardial salvage index (P = .28 and .65, respectively) or clinical adverse events. Patients who experienced an adverse event during follow-up had a slightly higher TEG-MA value than patients with an event-free follow-up, but this was not statistically significant (68.1 vs 67.3, P = .44).

CONCLUSIONS: The TEG-MA does not appear to be a sensitive predictor of reperfusion success and prognosis in urgent PCI for STEMI.

Original language	English
Journal	Clinical and Applied Thrombosis/Hemostasis
Volume	20
Issue number	8
Pages (from-to)	825-831
Number of pages	7
ISSN	1076-0296
DOIs	https://doi.org/10.1177/1076029613485411
Publication status	Published - 19 Nov 2014

Access to Document

10.1177/1076029613485411

Cite this

Dridi, N. P., Lønborg, J. T., Radu, M. D., Clemmensen, P., Engstrøm, T., Kelbæk, H., Jørgensen, E., Helqvist, S., Saunamäki, K., Christensen, T. H., Baeres, F. M. M., Johansson, P. I., & Holmvang, L. (2014). Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention. Clinical and Applied Thrombosis/Hemostasis, 20(8), 825-831. https://doi.org/10.1177/1076029613485411

Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention. / Dridi, Nadia Paarup; Lønborg, Jacob T; Radu, Maria D et al.

In: Clinical and Applied Thrombosis/Hemostasis, Vol. 20, No. 8, 19.11.2014, p. 825-831.

Research output: Contribution to journal › Journal article › Research › peer-review

Dridi, NP, Lønborg, JT, Radu, MD, Clemmensen, P, Engstrøm, T, Kelbæk, H, Jørgensen, E, Helqvist, S, Saunamäki, K, Christensen, TH, Baeres, FMM, Johansson, PI & Holmvang, L 2014, 'Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention', Clinical and Applied Thrombosis/Hemostasis, vol. 20, no. 8, pp. 825-831. https://doi.org/10.1177/1076029613485411

@article{08c617c0087440818f7e7fad34334bf0,

title = "Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention",

abstract = "OBJECTIVES: We investigated the relationship between coagulation assessed by thromboelastography (TEG) and myocardial damage in ST-segment elevation myocardial infarction (STEMI).METHODS: We measured platelet activity with TEG-maximum amplitude (TEG-MA) in 233 patients undergoing urgent percutaneous coronary intervention (PCI). Infarct size and myocardial salvage index were evaluated using cardiac magnetic resonance, and the relation of these parameters to posttreatment coagulation was examined retrospectively. Adverse events were adjudicated and related to the coagulation status during the index event.RESULTS: Hypercoagulation was found in 82 (35.2%) patients and was neither correlated to infarct size nor correlated to myocardial salvage index (P = .28 and .65, respectively) or clinical adverse events. Patients who experienced an adverse event during follow-up had a slightly higher TEG-MA value than patients with an event-free follow-up, but this was not statistically significant (68.1 vs 67.3, P = .44).CONCLUSIONS: The TEG-MA does not appear to be a sensitive predictor of reperfusion success and prognosis in urgent PCI for STEMI.",

author = "Dridi, {Nadia Paarup} and L{\o}nborg, {Jacob T} and Radu, {Maria D} and Peter Clemmensen and Thomas Engstr{\o}m and Henning Kelb{\ae}k and Erik J{\o}rgensen and Steffen Helqvist and Kari Saunam{\"a}ki and Christensen, {Troels H} and Baeres, {Florian M M} and Johansson, {P{\"a}r I} and Lene Holmvang",

note = "{\textcopyright} The Author(s) 2013.",

year = "2014",

month = nov,

day = "19",

doi = "10.1177/1076029613485411",

language = "English",

volume = "20",

pages = "825--831",

journal = "Clinical and Applied Thrombosis/Hemostasis",

issn = "1076-0296",

publisher = "SAGE Publications",

number = "8",

}

TY - JOUR

T1 - Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention

AU - Dridi, Nadia Paarup

AU - Lønborg, Jacob T

AU - Radu, Maria D

AU - Clemmensen, Peter

AU - Engstrøm, Thomas

AU - Kelbæk, Henning

AU - Jørgensen, Erik

AU - Helqvist, Steffen

AU - Saunamäki, Kari

AU - Christensen, Troels H

AU - Baeres, Florian M M

AU - Johansson, Pär I

AU - Holmvang, Lene

PY - 2014/11/19

Y1 - 2014/11/19

N2 - OBJECTIVES: We investigated the relationship between coagulation assessed by thromboelastography (TEG) and myocardial damage in ST-segment elevation myocardial infarction (STEMI).METHODS: We measured platelet activity with TEG-maximum amplitude (TEG-MA) in 233 patients undergoing urgent percutaneous coronary intervention (PCI). Infarct size and myocardial salvage index were evaluated using cardiac magnetic resonance, and the relation of these parameters to posttreatment coagulation was examined retrospectively. Adverse events were adjudicated and related to the coagulation status during the index event.RESULTS: Hypercoagulation was found in 82 (35.2%) patients and was neither correlated to infarct size nor correlated to myocardial salvage index (P = .28 and .65, respectively) or clinical adverse events. Patients who experienced an adverse event during follow-up had a slightly higher TEG-MA value than patients with an event-free follow-up, but this was not statistically significant (68.1 vs 67.3, P = .44).CONCLUSIONS: The TEG-MA does not appear to be a sensitive predictor of reperfusion success and prognosis in urgent PCI for STEMI.

AB - OBJECTIVES: We investigated the relationship between coagulation assessed by thromboelastography (TEG) and myocardial damage in ST-segment elevation myocardial infarction (STEMI).METHODS: We measured platelet activity with TEG-maximum amplitude (TEG-MA) in 233 patients undergoing urgent percutaneous coronary intervention (PCI). Infarct size and myocardial salvage index were evaluated using cardiac magnetic resonance, and the relation of these parameters to posttreatment coagulation was examined retrospectively. Adverse events were adjudicated and related to the coagulation status during the index event.RESULTS: Hypercoagulation was found in 82 (35.2%) patients and was neither correlated to infarct size nor correlated to myocardial salvage index (P = .28 and .65, respectively) or clinical adverse events. Patients who experienced an adverse event during follow-up had a slightly higher TEG-MA value than patients with an event-free follow-up, but this was not statistically significant (68.1 vs 67.3, P = .44).CONCLUSIONS: The TEG-MA does not appear to be a sensitive predictor of reperfusion success and prognosis in urgent PCI for STEMI.

U2 - 10.1177/1076029613485411

DO - 10.1177/1076029613485411

M3 - Journal article

C2 - 23613040

SN - 1076-0296

VL - 20

SP - 825

EP - 831

JO - Clinical and Applied Thrombosis/Hemostasis

JF - Clinical and Applied Thrombosis/Hemostasis

IS - 8

ER -

Hypercoagulation Assessed by Thromboelastography is Neither Related to Infarct Size nor to Clinical Outcome After Primary Percutaneous Coronary Intervention

Abstract

Access to Document

Fingerprint

Cite this