TY - JOUR
T1 - Human Papillomavirus Infection Among 2460 Men in Denmark
T2 - Prevalence in Relation to Age Using 2 Human Papillomavirus DNA Testing Methods
AU - Hebnes, Julie Buchholt
AU - Munk, Christian
AU - Nøhr, Bugge
AU - Nielsen, Ann
AU - Jørgensen, Hans Ole
AU - Iftner, Thomas
AU - Kjaer, Susanne Krüger
PY - 2015/8/25
Y1 - 2015/8/25
N2 - It is crucial to understand the epidemiology and natural history of human papillomavirus (HPV) infection in both men and women, to prevent the increasing HPV-related disease burden in men. Data on HPV prevalence among men in the general population are limited. In this cross-sectional population-based study, we aimed to estimate genital HPV infection prevalence in Danish men using 2 different test methods. Methods: Penile swab samples from2460male employees and conscripts at military barracks in Denmark were tested for HPV DNAwith the hybrid capture 2 (HC2) method, and a polymerase chain reaction (PCR) assay, Inno-LiPA. The overall and age-and type-specific prevalence of HPV infection with 95% confidence intervals (CIs) were estimated, and the correlation between the 2 assays was assessed. Results: The overall HPV prevalence was 22.2% (95% CI, 20.6-23.9) in the HC2 test and 41.8% (95% CI, 39.9-43.8) with PCR. Of the PCRpositive samples, 50.9% were negative in the HC2 test. Of 183 PCRpositive samples that could not be genotyped (HPVX), 88.0% (95% CI, 83.2-92.7) were HC2 negative. The most prevalent types were HPV-51, HPV-16, HPV-66, HPV-53, and HPV-6. The prevalence of high-risk and low-risk HPV peaked among men aged 20 to 29 years, whereas the HPVX prevalence increased with age. Conclusions: Human papillomavirus is highly prevalent in the general male population of Denmark, with HPV-16 and HPV-51 being the most prevalent. Polymerase chain reaction detects twice as many positive samples as HC2 but includes HPVX, possibly representing cutaneous HPV types found on normal genital skin.
AB - It is crucial to understand the epidemiology and natural history of human papillomavirus (HPV) infection in both men and women, to prevent the increasing HPV-related disease burden in men. Data on HPV prevalence among men in the general population are limited. In this cross-sectional population-based study, we aimed to estimate genital HPV infection prevalence in Danish men using 2 different test methods. Methods: Penile swab samples from2460male employees and conscripts at military barracks in Denmark were tested for HPV DNAwith the hybrid capture 2 (HC2) method, and a polymerase chain reaction (PCR) assay, Inno-LiPA. The overall and age-and type-specific prevalence of HPV infection with 95% confidence intervals (CIs) were estimated, and the correlation between the 2 assays was assessed. Results: The overall HPV prevalence was 22.2% (95% CI, 20.6-23.9) in the HC2 test and 41.8% (95% CI, 39.9-43.8) with PCR. Of the PCRpositive samples, 50.9% were negative in the HC2 test. Of 183 PCRpositive samples that could not be genotyped (HPVX), 88.0% (95% CI, 83.2-92.7) were HC2 negative. The most prevalent types were HPV-51, HPV-16, HPV-66, HPV-53, and HPV-6. The prevalence of high-risk and low-risk HPV peaked among men aged 20 to 29 years, whereas the HPVX prevalence increased with age. Conclusions: Human papillomavirus is highly prevalent in the general male population of Denmark, with HPV-16 and HPV-51 being the most prevalent. Polymerase chain reaction detects twice as many positive samples as HC2 but includes HPVX, possibly representing cutaneous HPV types found on normal genital skin.
U2 - 10.1097/OLQ.0000000000000315
DO - 10.1097/OLQ.0000000000000315
M3 - Journal article
C2 - 26165439
SN - 0148-5717
VL - 42
SP - 463
EP - 467
JO - Sexually Transmitted Diseases
JF - Sexually Transmitted Diseases
IS - 8
ER -
