How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology

Zhenhua Yang; Mariana Rosenthal; Noah A Rosenberg; Sarah Talarico; Lixin Zhang; Carl Marrs; Vibeke Østergaard Thomsen; Troels Lillebaek; Åse Bengård Andersen

doi:10.1016/j.meegid.2011.02.002

How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology

Zhenhua Yang, Mariana Rosenthal, Noah A Rosenberg, Sarah Talarico, Lixin Zhang, Carl Marrs, Vibeke Østergaard Thomsen, Troels Lillebaek, Åse Bengård Andersen

14 Citations (Scopus)

Abstract

Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI.

Original language	English
Journal	Infection, Genetics and Evolution
Volume	11
Issue number	5
Pages (from-to)	1164-1167
Number of pages	4
ISSN	1567-1348
DOIs	https://doi.org/10.1016/j.meegid.2011.02.002
Publication status	Published - Jul 2011

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title = "How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology",

abstract = "Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI.",

author = "Zhenhua Yang and Mariana Rosenthal and Rosenberg, {Noah A} and Sarah Talarico and Lixin Zhang and Carl Marrs and Thomsen, {Vibeke {\O}stergaard} and Troels Lillebaek and Andersen, {{\AA}se Beng{\aa}rd}",

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AU - Yang, Zhenhua

AU - Rosenthal, Mariana

AU - Rosenberg, Noah A

AU - Talarico, Sarah

AU - Zhang, Lixin

AU - Marrs, Carl

AU - Thomsen, Vibeke Østergaard

AU - Lillebaek, Troels

AU - Andersen, Åse Bengård

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N2 - Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI.

AB - Mycobacterium tuberculosis may survive for decades in the human body in a state termed latent tuberculosis infection (LTBI). We investigated the occurrence during LTBI of insertion/deletion events in a selected set of mononucleotide simple sequence repeats, DNA sequence changes in four M. tuberculosis genes, and large sequence variations in 4750 M. tuberculosis open reading frames. We studied 13 paired M. tuberculosis clinical isolates, with each pair representing a reactivation of LTBI more than three decades after primary infection. Absence of sequence variations between paired isolates in nearly all investigated loci suggests a low likelihood of bacterial replication during LTBI.

U2 - 10.1016/j.meegid.2011.02.002

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JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

IS - 5

ER -

How dormant is Mycobacterium tuberculosis during latency? A study integrating genomics and molecular epidemiology

Abstract

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