How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1

T B Rasmussen; M Manefield; Jens Bo Andersen; Leo Eberl; U Anthoni; C Christophersen; P Steinberg; S Kjelleberg; M Givskov

How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1

T B Rasmussen, M Manefield, Jens Bo Andersen, Leo Eberl, U Anthoni, C Christophersen, P Steinberg, S Kjelleberg, M Givskov

Department of Chemistry

197 Citations (Scopus)

Abstract

Halogenated furanones produced by the benthic marine macroalga Delisea pulchra inhibit swarming motility of Serratia liquefaciens MG1. This study demonstrates that exogenously added furanones control transcription of the quorum sensing regulated gene swrA in competition with the cognate signal molecule N:-butanoyl-L-homoserine lactone. This in turn results in reduced production of the surface-active compound serrawettin W2, which is crucial for surface translocation of the differentiated swarm cells. It is demonstrated that furanones interfere with interspecies communication during swarming of mixed cultures and that the mode of interference in quorum-sensing control and interspecies communication is not through inhibition of autoinducer synthesis.

Original language	English
Journal	Microbiology
Volume	146 Pt 12
Pages (from-to)	3237-44
Number of pages	8
ISSN	1350-0872
Publication status	Published - 2000

Keywords

4-Butyrolactone
Furans
Gene Expression Regulation, Bacterial
Lipoproteins
Luminescent Measurements
Movement
Peptides, Cyclic
Rhodophyta
Serratia
Signal Transduction
Transcription, Genetic

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title = "How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1",

abstract = "Halogenated furanones produced by the benthic marine macroalga Delisea pulchra inhibit swarming motility of Serratia liquefaciens MG1. This study demonstrates that exogenously added furanones control transcription of the quorum sensing regulated gene swrA in competition with the cognate signal molecule N:-butanoyl-L-homoserine lactone. This in turn results in reduced production of the surface-active compound serrawettin W2, which is crucial for surface translocation of the differentiated swarm cells. It is demonstrated that furanones interfere with interspecies communication during swarming of mixed cultures and that the mode of interference in quorum-sensing control and interspecies communication is not through inhibition of autoinducer synthesis.",

keywords = "4-Butyrolactone, Furans, Gene Expression Regulation, Bacterial, Lipoproteins, Luminescent Measurements, Movement, Peptides, Cyclic, Rhodophyta, Serratia, Signal Transduction, Transcription, Genetic",

author = "Rasmussen, {T B} and M Manefield and Andersen, {Jens Bo} and Leo Eberl and U Anthoni and C Christophersen and P Steinberg and S Kjelleberg and M Givskov",

year = "2000",

language = "English",

volume = "146 Pt 12",

pages = "3237--44",

journal = "Microbiology",

issn = "1350-0872",

publisher = "Society for General Microbiology",

}

TY - JOUR

T1 - How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1

AU - Rasmussen, T B

AU - Manefield, M

AU - Andersen, Jens Bo

AU - Eberl, Leo

AU - Anthoni, U

AU - Christophersen, C

AU - Steinberg, P

AU - Kjelleberg, S

AU - Givskov, M

PY - 2000

Y1 - 2000

N2 - Halogenated furanones produced by the benthic marine macroalga Delisea pulchra inhibit swarming motility of Serratia liquefaciens MG1. This study demonstrates that exogenously added furanones control transcription of the quorum sensing regulated gene swrA in competition with the cognate signal molecule N:-butanoyl-L-homoserine lactone. This in turn results in reduced production of the surface-active compound serrawettin W2, which is crucial for surface translocation of the differentiated swarm cells. It is demonstrated that furanones interfere with interspecies communication during swarming of mixed cultures and that the mode of interference in quorum-sensing control and interspecies communication is not through inhibition of autoinducer synthesis.

AB - Halogenated furanones produced by the benthic marine macroalga Delisea pulchra inhibit swarming motility of Serratia liquefaciens MG1. This study demonstrates that exogenously added furanones control transcription of the quorum sensing regulated gene swrA in competition with the cognate signal molecule N:-butanoyl-L-homoserine lactone. This in turn results in reduced production of the surface-active compound serrawettin W2, which is crucial for surface translocation of the differentiated swarm cells. It is demonstrated that furanones interfere with interspecies communication during swarming of mixed cultures and that the mode of interference in quorum-sensing control and interspecies communication is not through inhibition of autoinducer synthesis.

KW - 4-Butyrolactone

KW - Furans

KW - Gene Expression Regulation, Bacterial

KW - Lipoproteins

KW - Luminescent Measurements

KW - Movement

KW - Peptides, Cyclic

KW - Rhodophyta

KW - Serratia

KW - Signal Transduction

KW - Transcription, Genetic

M3 - Journal article

C2 - 11101681

SN - 1350-0872

VL - 146 Pt 12

SP - 3237

EP - 3244

JO - Microbiology

JF - Microbiology

ER -

How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1

Abstract

Keywords

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