Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera

Zoran Jaglic; Edita Jeklova; Henrik Christensen; Lenka Leva; Karen Register; Vladimir Kummer; Zdenka Kucerova; Martin Faldyna; Jarmila Maskova; Katerina Nedbalcova

Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera

Zoran Jaglic, Edita Jeklova, Henrik Christensen, Lenka Leva, Karen Register, Vladimir Kummer, Zdenka Kucerova, Martin Faldyna, Jarmila Maskova, Katerina Nedbalcova

9 Citations (Scopus)

Abstract

Although Pasteurella multocida serogroup F has been described as an avian-adapted serogroup, it was recently found in rabbit nests in the Czech Republic. Therefore, the ability of 2 avian P. multocida serogroup F strains to induce disease in rabbits was investigated. Two groups of 18 Pasteurella-free rabbits were intranasally challenged with strains isolated from chickens and turkeys. Half of the animals in each challenge group were immunosuppressed using dexamethasone. All of the challenged rabbits exhibited clinical signs of peracute septicemic disease, ending with shock, and died or were euthanized in the terminal stages of the disease 1 to 2 d post-infection. Gross pathological changes included systemic vascular collapse and vascular leak syndrome. Hyperemia, hemorrhage, edema, inflammatory cell infiltrates, focal necrosis, and degenerative changes were observed histologically in parenchymatous organs. This is the first study directly demonstrating that avian P. multocida serogroup F strains are highly virulent in rabbits and that avian hosts cannot be excluded as a possible source of rabbit infection with serogroup F.

Original language	English
Journal	Canadian Journal of Veterinary Research
Volume	75
Issue number	3
Pages (from-to)	200-208
Number of pages	9
ISSN	0830-9000
Publication status	Published - Jul 2011

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Jaglic, Z, Jeklova, E, Christensen, H, Leva, L, Register, K, Kummer, V, Kucerova, Z, Faldyna, M, Maskova, J & Nedbalcova, K 2011, 'Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera', Canadian Journal of Veterinary Research, vol. 75, no. 3, pp. 200-208. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122976/>

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title = "Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera",

abstract = "Although Pasteurella multocida serogroup F has been described as an avian-adapted serogroup, it was recently found in rabbit nests in the Czech Republic. Therefore, the ability of 2 avian P. multocida serogroup F strains to induce disease in rabbits was investigated. Two groups of 18 Pasteurella-free rabbits were intranasally challenged with strains isolated from chickens and turkeys. Half of the animals in each challenge group were immunosuppressed using dexamethasone. All of the challenged rabbits exhibited clinical signs of peracute septicemic disease, ending with shock, and died or were euthanized in the terminal stages of the disease 1 to 2 d post-infection. Gross pathological changes included systemic vascular collapse and vascular leak syndrome. Hyperemia, hemorrhage, edema, inflammatory cell infiltrates, focal necrosis, and degenerative changes were observed histologically in parenchymatous organs. This is the first study directly demonstrating that avian P. multocida serogroup F strains are highly virulent in rabbits and that avian hosts cannot be excluded as a possible source of rabbit infection with serogroup F.",

author = "Zoran Jaglic and Edita Jeklova and Henrik Christensen and Lenka Leva and Karen Register and Vladimir Kummer and Zdenka Kucerova and Martin Faldyna and Jarmila Maskova and Katerina Nedbalcova",

year = "2011",

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language = "English",

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journal = "Canadian Journal of Veterinary Research",

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T1 - Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera

AU - Jaglic, Zoran

AU - Jeklova, Edita

AU - Christensen, Henrik

AU - Leva, Lenka

AU - Register, Karen

AU - Kummer, Vladimir

AU - Kucerova, Zdenka

AU - Faldyna, Martin

AU - Maskova, Jarmila

AU - Nedbalcova, Katerina

PY - 2011/7

Y1 - 2011/7

N2 - Although Pasteurella multocida serogroup F has been described as an avian-adapted serogroup, it was recently found in rabbit nests in the Czech Republic. Therefore, the ability of 2 avian P. multocida serogroup F strains to induce disease in rabbits was investigated. Two groups of 18 Pasteurella-free rabbits were intranasally challenged with strains isolated from chickens and turkeys. Half of the animals in each challenge group were immunosuppressed using dexamethasone. All of the challenged rabbits exhibited clinical signs of peracute septicemic disease, ending with shock, and died or were euthanized in the terminal stages of the disease 1 to 2 d post-infection. Gross pathological changes included systemic vascular collapse and vascular leak syndrome. Hyperemia, hemorrhage, edema, inflammatory cell infiltrates, focal necrosis, and degenerative changes were observed histologically in parenchymatous organs. This is the first study directly demonstrating that avian P. multocida serogroup F strains are highly virulent in rabbits and that avian hosts cannot be excluded as a possible source of rabbit infection with serogroup F.

AB - Although Pasteurella multocida serogroup F has been described as an avian-adapted serogroup, it was recently found in rabbit nests in the Czech Republic. Therefore, the ability of 2 avian P. multocida serogroup F strains to induce disease in rabbits was investigated. Two groups of 18 Pasteurella-free rabbits were intranasally challenged with strains isolated from chickens and turkeys. Half of the animals in each challenge group were immunosuppressed using dexamethasone. All of the challenged rabbits exhibited clinical signs of peracute septicemic disease, ending with shock, and died or were euthanized in the terminal stages of the disease 1 to 2 d post-infection. Gross pathological changes included systemic vascular collapse and vascular leak syndrome. Hyperemia, hemorrhage, edema, inflammatory cell infiltrates, focal necrosis, and degenerative changes were observed histologically in parenchymatous organs. This is the first study directly demonstrating that avian P. multocida serogroup F strains are highly virulent in rabbits and that avian hosts cannot be excluded as a possible source of rabbit infection with serogroup F.

M3 - Journal article

SN - 0830-9000

VL - 75

SP - 200

EP - 208

JO - Canadian Journal of Veterinary Research

JF - Canadian Journal of Veterinary Research

IS - 3

ER -

Host response in rabbits to infection with Pasteurella multocida serogroup F strains originating from fowl cholera

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