HLA-DP and bonemarrow transplantation: DP-incompatibility and severe acute graft versus host disease

Niels Ødum; P Platz; B K Jakobsen; Claus Munck Petersen; N Jacobsen; J Møller; L P Ryder; L Lamm; A Svejgaard

doi:doi: 10.1111/j.1399-0039.1987.tb01624.x

HLA-DP and bonemarrow transplantation: DP-incompatibility and severe acute graft versus host disease

Niels Ødum, P Platz, B K Jakobsen, Claus Munck Petersen, N Jacobsen, J Møller, L P Ryder, L Lamm, A Svejgaard

22 Citations (Scopus)

Abstract

The presence of activated T cells as judged from the reaction with monoclonal antibodies (MoAb) against (a) a late stage T cell activation antigen (VLA-1), (b) the interleukin 2 (IL2) receptor (CD25), and (c) four different HLA class II molecules (HLA-DR, DRw52, DQ, and DP) was studied in 15 patients with active juvenile chronic arthritis (JCA), 10 patients with JCA in remission, and 11 age matched, healthy controls. In addition, the distribution of T 'helper/inducer' (CD4+), T 'suppressor/inducer' (CD4+, Leu8+), T 'suppressor/cytotoxic' (CD8+), and 'natural killer' (NK) cells (CD16+) was studied. Twenty patients and six controls were investigated for the capability to stimulate alloreactivated primed lymphocytes. The prevalence of VLA-1 positive, large cells was significantly increased to 5% (median value) in active JCA as compared with JCA in remission (2%, p less than 0.05) and controls (1%, p less than 0.05), whereas no significant difference between JCA in remission and controls was observed. Except for two patients with active JCA, less than 1% IL2 receptor bearing cells were found in patients with JCA and controls. No significant difference in the prevalence and expression of the various HLA class II antigens was observed between the groups. Similarly, no significant differences in stimulatory capability in secondary mixed lymphocyte culture (MLC) were seen. The distribution of T helper/inducer (CD4+), T suppressor/cytotoxic (CD8+), and NK cells was similar in active JCA, JCA in remission, and controls. The prevalence of T suppressor/inducer (CD4+,Leu8+) cells was higher in remission JCA (17%) than in active JCA (11%) and controls (10%). This increase, however, did not reach statistical significance. In conclusion, late stage but not early stage T cell activation antigens were increased in patients with active JCA as compared with patients with JCA in remission and control, whereas some patients in remission had an increased prevalence of T suppressor/inducer cells.

Original language	English
Journal	HLA
Volume	30
Issue number	5
Pages (from-to)	213-16
Number of pages	4
ISSN	2059-2302
DOIs	https://doi.org/doi: 10.1111/j.1399-0039.1987.tb01624.x
Publication status	Published - 1987

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doi: 10.1111/j.1399-0039.1987.tb01624.x

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@article{20f50cd0fda311ddb219000ea68e967b,

title = "HLA-DP and bonemarrow transplantation: DP-incompatibility and severe acute graft versus host disease",

abstract = "The presence of activated T cells as judged from the reaction with monoclonal antibodies (MoAb) against (a) a late stage T cell activation antigen (VLA-1), (b) the interleukin 2 (IL2) receptor (CD25), and (c) four different HLA class II molecules (HLA-DR, DRw52, DQ, and DP) was studied in 15 patients with active juvenile chronic arthritis (JCA), 10 patients with JCA in remission, and 11 age matched, healthy controls. In addition, the distribution of T 'helper/inducer' (CD4+), T 'suppressor/inducer' (CD4+, Leu8+), T 'suppressor/cytotoxic' (CD8+), and 'natural killer' (NK) cells (CD16+) was studied. Twenty patients and six controls were investigated for the capability to stimulate alloreactivated primed lymphocytes. The prevalence of VLA-1 positive, large cells was significantly increased to 5% (median value) in active JCA as compared with JCA in remission (2%, p less than 0.05) and controls (1%, p less than 0.05), whereas no significant difference between JCA in remission and controls was observed. Except for two patients with active JCA, less than 1% IL2 receptor bearing cells were found in patients with JCA and controls. No significant difference in the prevalence and expression of the various HLA class II antigens was observed between the groups. Similarly, no significant differences in stimulatory capability in secondary mixed lymphocyte culture (MLC) were seen. The distribution of T helper/inducer (CD4+), T suppressor/cytotoxic (CD8+), and NK cells was similar in active JCA, JCA in remission, and controls. The prevalence of T suppressor/inducer (CD4+,Leu8+) cells was higher in remission JCA (17%) than in active JCA (11%) and controls (10%). This increase, however, did not reach statistical significance. In conclusion, late stage but not early stage T cell activation antigens were increased in patients with active JCA as compared with patients with JCA in remission and control, whereas some patients in remission had an increased prevalence of T suppressor/inducer cells.",

author = "Niels {\O}dum and P Platz and Jakobsen, {B K} and Petersen, {Claus Munck} and N Jacobsen and J M{\o}ller and Ryder, {L P} and L Lamm and A Svejgaard",

note = "Keywords: Adolescent; Antibodies, Monoclonal; Antigens, CD27; Antigens, Surface; Arthritis; Child; Child, Preschool; Female; HLA-D Antigens; Histocompatibility Antigens Class II; Humans; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes",

year = "1987",

doi = "doi: 10.1111/j.1399-0039.1987.tb01624.x",

language = "English",

volume = "30",

pages = "213--16",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley",

number = "5",

}

TY - JOUR

T1 - HLA-DP and bonemarrow transplantation: DP-incompatibility and severe acute graft versus host disease

AU - Ødum, Niels

AU - Platz, P

AU - Jakobsen, B K

AU - Petersen, Claus Munck

AU - Jacobsen, N

AU - Møller, J

AU - Ryder, L P

AU - Lamm, L

AU - Svejgaard, A

N1 - Keywords: Adolescent; Antibodies, Monoclonal; Antigens, CD27; Antigens, Surface; Arthritis; Child; Child, Preschool; Female; HLA-D Antigens; Histocompatibility Antigens Class II; Humans; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Male; Receptors, Antigen, T-Cell; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes

PY - 1987

Y1 - 1987

N2 - The presence of activated T cells as judged from the reaction with monoclonal antibodies (MoAb) against (a) a late stage T cell activation antigen (VLA-1), (b) the interleukin 2 (IL2) receptor (CD25), and (c) four different HLA class II molecules (HLA-DR, DRw52, DQ, and DP) was studied in 15 patients with active juvenile chronic arthritis (JCA), 10 patients with JCA in remission, and 11 age matched, healthy controls. In addition, the distribution of T 'helper/inducer' (CD4+), T 'suppressor/inducer' (CD4+, Leu8+), T 'suppressor/cytotoxic' (CD8+), and 'natural killer' (NK) cells (CD16+) was studied. Twenty patients and six controls were investigated for the capability to stimulate alloreactivated primed lymphocytes. The prevalence of VLA-1 positive, large cells was significantly increased to 5% (median value) in active JCA as compared with JCA in remission (2%, p less than 0.05) and controls (1%, p less than 0.05), whereas no significant difference between JCA in remission and controls was observed. Except for two patients with active JCA, less than 1% IL2 receptor bearing cells were found in patients with JCA and controls. No significant difference in the prevalence and expression of the various HLA class II antigens was observed between the groups. Similarly, no significant differences in stimulatory capability in secondary mixed lymphocyte culture (MLC) were seen. The distribution of T helper/inducer (CD4+), T suppressor/cytotoxic (CD8+), and NK cells was similar in active JCA, JCA in remission, and controls. The prevalence of T suppressor/inducer (CD4+,Leu8+) cells was higher in remission JCA (17%) than in active JCA (11%) and controls (10%). This increase, however, did not reach statistical significance. In conclusion, late stage but not early stage T cell activation antigens were increased in patients with active JCA as compared with patients with JCA in remission and control, whereas some patients in remission had an increased prevalence of T suppressor/inducer cells.

AB - The presence of activated T cells as judged from the reaction with monoclonal antibodies (MoAb) against (a) a late stage T cell activation antigen (VLA-1), (b) the interleukin 2 (IL2) receptor (CD25), and (c) four different HLA class II molecules (HLA-DR, DRw52, DQ, and DP) was studied in 15 patients with active juvenile chronic arthritis (JCA), 10 patients with JCA in remission, and 11 age matched, healthy controls. In addition, the distribution of T 'helper/inducer' (CD4+), T 'suppressor/inducer' (CD4+, Leu8+), T 'suppressor/cytotoxic' (CD8+), and 'natural killer' (NK) cells (CD16+) was studied. Twenty patients and six controls were investigated for the capability to stimulate alloreactivated primed lymphocytes. The prevalence of VLA-1 positive, large cells was significantly increased to 5% (median value) in active JCA as compared with JCA in remission (2%, p less than 0.05) and controls (1%, p less than 0.05), whereas no significant difference between JCA in remission and controls was observed. Except for two patients with active JCA, less than 1% IL2 receptor bearing cells were found in patients with JCA and controls. No significant difference in the prevalence and expression of the various HLA class II antigens was observed between the groups. Similarly, no significant differences in stimulatory capability in secondary mixed lymphocyte culture (MLC) were seen. The distribution of T helper/inducer (CD4+), T suppressor/cytotoxic (CD8+), and NK cells was similar in active JCA, JCA in remission, and controls. The prevalence of T suppressor/inducer (CD4+,Leu8+) cells was higher in remission JCA (17%) than in active JCA (11%) and controls (10%). This increase, however, did not reach statistical significance. In conclusion, late stage but not early stage T cell activation antigens were increased in patients with active JCA as compared with patients with JCA in remission and control, whereas some patients in remission had an increased prevalence of T suppressor/inducer cells.

U2 - doi: 10.1111/j.1399-0039.1987.tb01624.x

DO - doi: 10.1111/j.1399-0039.1987.tb01624.x

M3 - Journal article

C2 - 3617032

SN - 2059-2302

VL - 30

SP - 213

EP - 216

JO - HLA

JF - HLA

IS - 5

ER -

HLA-DP and bonemarrow transplantation: DP-incompatibility and severe acute graft versus host disease

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