HLA-DP and bone marrow transplantation: DP-incompatibility and severe acute graft versus host disease

TY - JOUR

T1 - HLA-DP and bone marrow transplantation: DP-incompatibility and severe acute graft versus host disease

AU - Ødum, Niels

AU - Platz, P

AU - Jakobsen, B K

AU - Petersen, C M

AU - Jacobsen, N

AU - Møller, J

AU - Ryder, L P

AU - Lamm, L

AU - Svejgaard, A

N1 - Keywords: Bone Marrow Transplantation; Graft vs Host Disease; HLA-D Antigens; HLA-DP Antigens; Haplotypes; Humans; Transplantation Immunology

PY - 1987

Y1 - 1987

N2 - Thirteen recipients of HLA-haploidentical, DR compatible bone marrow (BM) and the corresponding BM donors were HLA-DP typed using primed lymphocyte typing (PLT). Severe acute GVHD (greater than or equal to grade 2) developed within 3 months after BM-transplantation in all of eight recipients of DP incompatible BM, but in none of five recipients of DP-compatible BM. This difference was highly significant (p less than 0.001, Fisher's exact test). Moreover, severe acute GVHD was significantly increased in recipients of haploidentical, DR compatible, but DP incompatible BM as compared to severe acute GVHD in 88 recipients of HLA-identical BM (p less than 0.0001). In contrast, there was no difference in acute GVHD between recipients of haploidentical, DR and DP compatible BM and recipients of HLA-identical BM. The data presented here provide strong evidence for the first time that HLA-DP antigens play a role as transplantation antigens.

AB - Thirteen recipients of HLA-haploidentical, DR compatible bone marrow (BM) and the corresponding BM donors were HLA-DP typed using primed lymphocyte typing (PLT). Severe acute GVHD (greater than or equal to grade 2) developed within 3 months after BM-transplantation in all of eight recipients of DP incompatible BM, but in none of five recipients of DP-compatible BM. This difference was highly significant (p less than 0.001, Fisher's exact test). Moreover, severe acute GVHD was significantly increased in recipients of haploidentical, DR compatible, but DP incompatible BM as compared to severe acute GVHD in 88 recipients of HLA-identical BM (p less than 0.0001). In contrast, there was no difference in acute GVHD between recipients of haploidentical, DR and DP compatible BM and recipients of HLA-identical BM. The data presented here provide strong evidence for the first time that HLA-DP antigens play a role as transplantation antigens.

M3 - Journal article

C2 - 3326216

SN - 2059-2302

VL - 30

SP - 213

EP - 216

JO - HLA

JF - HLA

IS - 5

ER -