HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients

Wenna Nascimento Melsted; Lasse Lindholm Johansen; Jørgen Lock-Andersen; Nille Behrendt; Jens Ole Eriksen; Michael Bzorek; Thomas Scheike; Thomas Vauvert F. Hviid

doi:10.1016/j.clim.2017.09.004

HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients

Wenna Nascimento Melsted, Lasse Lindholm Johansen, Jørgen Lock-Andersen, Nille Behrendt, Jens Ole Eriksen, Michael Bzorek, Thomas Scheike, Thomas Vauvert F. Hviid^*

^*Corresponding author for this work

14 Citations (Scopus)

Abstract

HLA class Ia (HLA-ABC) and HLA class Ib (HLA-E, -F and -G) molecules and FOXP3+ tumor-infiltrating lymphocytes (TILs) are often reported as relevant factors of tumor immune regulation. We investigated their expression as prognostic factors in 200 patients with primary cutaneous melanoma (PCM). In our cohort, patients with tumors showing upregulation of HLA-ABC molecules had significantly thicker tumors (32% vs 7%, P < 0.001), frequent ulceration (20% vs 6%, P = 0.007) and frequent nodular melanomas (20% vs 4%, P = 0.001). Additionally, high expression of HLA-G in the tumor was a sign of bad prognosis for the patients, being associated with thick tumors (30% vs 12%, P = 0.017), ulceration (24% vs 5%, P < 0.001) and positive sentinel node (13% vs 6%, P = 0.015). HLA-E, HLA-F and FOXP3+ TILs were not indicative of the prognosis in PCM. High HLA-ABC and HLA-G were associated with tumor aggressiveness and could be relevant predictive markers for effective immunotherapy of melanoma tumors.

Original language	English
Journal	Clinical Immunology
Volume	183
Pages (from-to)	191-197
ISSN	1521-6616
DOIs	https://doi.org/10.1016/j.clim.2017.09.004
Publication status	Published - 2017

Keywords

FOXP3+
HLA
Malignant melanoma
Prognosis
Regulatory T cells

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@article{c1012227f03a4cc89a36205246714d21,

title = "HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients",

abstract = "HLA class Ia (HLA-ABC) and HLA class Ib (HLA-E, -F and -G) molecules and FOXP3+ tumor-infiltrating lymphocytes (TILs) are often reported as relevant factors of tumor immune regulation. We investigated their expression as prognostic factors in 200 patients with primary cutaneous melanoma (PCM). In our cohort, patients with tumors showing upregulation of HLA-ABC molecules had significantly thicker tumors (32% vs 7%, P < 0.001), frequent ulceration (20% vs 6%, P = 0.007) and frequent nodular melanomas (20% vs 4%, P = 0.001). Additionally, high expression of HLA-G in the tumor was a sign of bad prognosis for the patients, being associated with thick tumors (30% vs 12%, P = 0.017), ulceration (24% vs 5%, P < 0.001) and positive sentinel node (13% vs 6%, P = 0.015). HLA-E, HLA-F and FOXP3+ TILs were not indicative of the prognosis in PCM. High HLA-ABC and HLA-G were associated with tumor aggressiveness and could be relevant predictive markers for effective immunotherapy of melanoma tumors.",

keywords = "FOXP3+, HLA, Malignant melanoma, Prognosis, Regulatory T cells",

author = "Melsted, {Wenna Nascimento} and Johansen, {Lasse Lindholm} and J{\o}rgen Lock-Andersen and Nille Behrendt and Eriksen, {Jens Ole} and Michael Bzorek and Thomas Scheike and Hviid, {Thomas Vauvert F.}",

year = "2017",

doi = "10.1016/j.clim.2017.09.004",

language = "English",

volume = "183",

pages = "191--197",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press",

}

TY - JOUR

T1 - HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients

AU - Melsted, Wenna Nascimento

AU - Johansen, Lasse Lindholm

AU - Lock-Andersen, Jørgen

AU - Behrendt, Nille

AU - Eriksen, Jens Ole

AU - Bzorek, Michael

AU - Scheike, Thomas

AU - Hviid, Thomas Vauvert F.

PY - 2017

Y1 - 2017

N2 - HLA class Ia (HLA-ABC) and HLA class Ib (HLA-E, -F and -G) molecules and FOXP3+ tumor-infiltrating lymphocytes (TILs) are often reported as relevant factors of tumor immune regulation. We investigated their expression as prognostic factors in 200 patients with primary cutaneous melanoma (PCM). In our cohort, patients with tumors showing upregulation of HLA-ABC molecules had significantly thicker tumors (32% vs 7%, P < 0.001), frequent ulceration (20% vs 6%, P = 0.007) and frequent nodular melanomas (20% vs 4%, P = 0.001). Additionally, high expression of HLA-G in the tumor was a sign of bad prognosis for the patients, being associated with thick tumors (30% vs 12%, P = 0.017), ulceration (24% vs 5%, P < 0.001) and positive sentinel node (13% vs 6%, P = 0.015). HLA-E, HLA-F and FOXP3+ TILs were not indicative of the prognosis in PCM. High HLA-ABC and HLA-G were associated with tumor aggressiveness and could be relevant predictive markers for effective immunotherapy of melanoma tumors.

AB - HLA class Ia (HLA-ABC) and HLA class Ib (HLA-E, -F and -G) molecules and FOXP3+ tumor-infiltrating lymphocytes (TILs) are often reported as relevant factors of tumor immune regulation. We investigated their expression as prognostic factors in 200 patients with primary cutaneous melanoma (PCM). In our cohort, patients with tumors showing upregulation of HLA-ABC molecules had significantly thicker tumors (32% vs 7%, P < 0.001), frequent ulceration (20% vs 6%, P = 0.007) and frequent nodular melanomas (20% vs 4%, P = 0.001). Additionally, high expression of HLA-G in the tumor was a sign of bad prognosis for the patients, being associated with thick tumors (30% vs 12%, P = 0.017), ulceration (24% vs 5%, P < 0.001) and positive sentinel node (13% vs 6%, P = 0.015). HLA-E, HLA-F and FOXP3+ TILs were not indicative of the prognosis in PCM. High HLA-ABC and HLA-G were associated with tumor aggressiveness and could be relevant predictive markers for effective immunotherapy of melanoma tumors.

KW - FOXP3+

KW - HLA

KW - Malignant melanoma

KW - Prognosis

KW - Regulatory T cells

U2 - 10.1016/j.clim.2017.09.004

DO - 10.1016/j.clim.2017.09.004

M3 - Journal article

C2 - 28882620

AN - SCOPUS:85029356272

SN - 1521-6616

VL - 183

SP - 191

EP - 197

JO - Clinical Immunology

JF - Clinical Immunology

ER -

HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients

Abstract

Keywords

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