Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases

Rikke Løvendahl Eefsen; Gert G Van den Eynden; Gunilla Høyer-Hansen; Pnina Brodt; Ole Didrik Laerum; Peter B Vermeulen; Ib Jarle Christensen; André Wettergren; Birgitte Federspiel; Gro L Willemoe; Ben Vainer; Kell Osterlind; Martin Illemann

doi:10.1155/2012/907971

Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases

Rikke Løvendahl Eefsen, Gert G Van den Eynden, Gunilla Høyer-Hansen, Pnina Brodt, Ole Didrik Laerum, Peter B Vermeulen, Ib Jarle Christensen, André Wettergren, Birgitte Federspiel, Gro L Willemoe, Ben Vainer, Kell Osterlind, Martin Illemann

Nutritional Immunology

37 Citations (Scopus)

Abstract

The purpose of this study was to characterise growth patterns, proteolysis, and angiogenesis in colorectal liver metastases from chemonaive patients with multiple liver metastases. Twenty-four patients were included in the study, resected for a median of 2.6 metastases. The growth pattern distribution was 25.8% desmoplastic, 33.9% pushing, and 21% replacement. In 20 patients, identical growth patterns were detected in all metastases, but in 8 of these patients, a second growth pattern was also present in one or two of the metastases. In the remaining 4 patients, no general growth pattern was observed, although none of the liver metastases included more than two growth patterns. Overall, a mixed growth pattern was demonstrated in 19.3% of the liver metastases. Compared to metastases with pushing, those with desmoplastic growth pattern had a significantly up-regulated expression of urokinase-type plasminogen activator receptor (P = 0.0008). Angiogenesis was most pronounced in metastases with a pushing growth pattern in comparison to those with desmoplastic (P = 0.0007) and replacement growth pattern (P = 0.021). Although a minor fraction of the patients harboured metastases with different growth patterns, we observed a tendency toward growth pattern uniformity in the liver metastases arising in the same patient. The result suggests that the growth pattern of liver metastases is not a random phenomenon.

Original language	English
Journal	Journal of Oncology
Volume	2012
Pages (from-to)	907971
ISSN	1687-8450
DOIs	https://doi.org/10.1155/2012/907971
Publication status	Published - 2012

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Eefsen, R. L., Van den Eynden, G. G., Høyer-Hansen, G., Brodt, P., Laerum, O. D., Vermeulen, P. B., Christensen, I. J., Wettergren, A., Federspiel, B., Willemoe, G. L., Vainer, B., Osterlind, K., & Illemann, M. (2012). Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases. Journal of Oncology, 2012, 907971. https://doi.org/10.1155/2012/907971

Eefsen, RL, Van den Eynden, GG, Høyer-Hansen, G, Brodt, P, Laerum, OD, Vermeulen, PB, Christensen, IJ, Wettergren, A, Federspiel, B, Willemoe, GL, Vainer, B, Osterlind, K & Illemann, M 2012, 'Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases', Journal of Oncology, vol. 2012, pp. 907971. https://doi.org/10.1155/2012/907971

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title = "Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases",

abstract = "The purpose of this study was to characterise growth patterns, proteolysis, and angiogenesis in colorectal liver metastases from chemonaive patients with multiple liver metastases. Twenty-four patients were included in the study, resected for a median of 2.6 metastases. The growth pattern distribution was 25.8% desmoplastic, 33.9% pushing, and 21% replacement. In 20 patients, identical growth patterns were detected in all metastases, but in 8 of these patients, a second growth pattern was also present in one or two of the metastases. In the remaining 4 patients, no general growth pattern was observed, although none of the liver metastases included more than two growth patterns. Overall, a mixed growth pattern was demonstrated in 19.3% of the liver metastases. Compared to metastases with pushing, those with desmoplastic growth pattern had a significantly up-regulated expression of urokinase-type plasminogen activator receptor (P = 0.0008). Angiogenesis was most pronounced in metastases with a pushing growth pattern in comparison to those with desmoplastic (P = 0.0007) and replacement growth pattern (P = 0.021). Although a minor fraction of the patients harboured metastases with different growth patterns, we observed a tendency toward growth pattern uniformity in the liver metastases arising in the same patient. The result suggests that the growth pattern of liver metastases is not a random phenomenon.",

author = "Eefsen, {Rikke L{\o}vendahl} and {Van den Eynden}, {Gert G} and Gunilla H{\o}yer-Hansen and Pnina Brodt and Laerum, {Ole Didrik} and Vermeulen, {Peter B} and Christensen, {Ib Jarle} and Andr{\'e} Wettergren and Birgitte Federspiel and Willemoe, {Gro L} and Ben Vainer and Kell Osterlind and Martin Illemann",

year = "2012",

doi = "10.1155/2012/907971",

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T1 - Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases

AU - Eefsen, Rikke Løvendahl

AU - Van den Eynden, Gert G

AU - Høyer-Hansen, Gunilla

AU - Brodt, Pnina

AU - Laerum, Ole Didrik

AU - Vermeulen, Peter B

AU - Christensen, Ib Jarle

AU - Wettergren, André

AU - Federspiel, Birgitte

AU - Willemoe, Gro L

AU - Vainer, Ben

AU - Osterlind, Kell

AU - Illemann, Martin

PY - 2012

Y1 - 2012

N2 - The purpose of this study was to characterise growth patterns, proteolysis, and angiogenesis in colorectal liver metastases from chemonaive patients with multiple liver metastases. Twenty-four patients were included in the study, resected for a median of 2.6 metastases. The growth pattern distribution was 25.8% desmoplastic, 33.9% pushing, and 21% replacement. In 20 patients, identical growth patterns were detected in all metastases, but in 8 of these patients, a second growth pattern was also present in one or two of the metastases. In the remaining 4 patients, no general growth pattern was observed, although none of the liver metastases included more than two growth patterns. Overall, a mixed growth pattern was demonstrated in 19.3% of the liver metastases. Compared to metastases with pushing, those with desmoplastic growth pattern had a significantly up-regulated expression of urokinase-type plasminogen activator receptor (P = 0.0008). Angiogenesis was most pronounced in metastases with a pushing growth pattern in comparison to those with desmoplastic (P = 0.0007) and replacement growth pattern (P = 0.021). Although a minor fraction of the patients harboured metastases with different growth patterns, we observed a tendency toward growth pattern uniformity in the liver metastases arising in the same patient. The result suggests that the growth pattern of liver metastases is not a random phenomenon.

AB - The purpose of this study was to characterise growth patterns, proteolysis, and angiogenesis in colorectal liver metastases from chemonaive patients with multiple liver metastases. Twenty-four patients were included in the study, resected for a median of 2.6 metastases. The growth pattern distribution was 25.8% desmoplastic, 33.9% pushing, and 21% replacement. In 20 patients, identical growth patterns were detected in all metastases, but in 8 of these patients, a second growth pattern was also present in one or two of the metastases. In the remaining 4 patients, no general growth pattern was observed, although none of the liver metastases included more than two growth patterns. Overall, a mixed growth pattern was demonstrated in 19.3% of the liver metastases. Compared to metastases with pushing, those with desmoplastic growth pattern had a significantly up-regulated expression of urokinase-type plasminogen activator receptor (P = 0.0008). Angiogenesis was most pronounced in metastases with a pushing growth pattern in comparison to those with desmoplastic (P = 0.0007) and replacement growth pattern (P = 0.021). Although a minor fraction of the patients harboured metastases with different growth patterns, we observed a tendency toward growth pattern uniformity in the liver metastases arising in the same patient. The result suggests that the growth pattern of liver metastases is not a random phenomenon.

U2 - 10.1155/2012/907971

DO - 10.1155/2012/907971

M3 - Journal article

C2 - 22919385

SN - 1687-8450

VL - 2012

SP - 907971

JO - Journal of Oncology

JF - Journal of Oncology

ER -

Histopathological growth pattern, proteolysis and angiogenesis in chemonaive patients resected for multiple colorectal liver metastases

Abstract

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