Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

Loredana Poeta; Agnese Padula; Benedetta Attianese; Mariaelena Valentino; Lucia Verrillo; Stefania Filosa; Cheryl Shoubridge; Adriano Barra; Charles E. Schwartz; Jesper Christensen; Hans van Bokhoven; Kristian Helin; Maria Brigida Lioi; Patrick Collombat; Jozef Gecz; Lucia Altucci; Elia Di Schiavi; Maria GIuseppina Miano

doi:10.1093/hmg/ddz254

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

Loredana Poeta, Agnese Padula, Benedetta Attianese, Mariaelena Valentino, Lucia Verrillo, Stefania Filosa, Cheryl Shoubridge, Adriano Barra, Charles E. Schwartz, Jesper Christensen, Hans van Bokhoven, Kristian Helin, Maria Brigida Lioi, Patrick Collombat, Jozef Gecz, Lucia Altucci, Elia Di Schiavi, Maria GIuseppina Miano^*

^*Corresponding author for this work

4 Citations (Scopus)

Original language	English
Journal	Human Molecular Genetics
Volume	28
Issue number	24
Pages (from-to)	4089-4102
Number of pages	14
ISSN	0964-6906
DOIs	https://doi.org/10.1093/hmg/ddz254
Publication status	Published - 15 Dec 2019

Keywords

LINKED MENTAL-RETARDATION
CONTROLS AXON GUIDANCE
EMBRYONIC STEM-CELLS
INTELLECTUAL DISABILITY
DEACETYLASE INHIBITORS
H3K4 METHYLATION
IMPAIRED REMOVAL
PHF8 GENE
MUTATIONS
BDNF

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Poeta, L., Padula, A., Attianese, B., Valentino, M., Verrillo, L., Filosa, S., Shoubridge, C., Barra, A., Schwartz, C. E., Christensen, J., van Bokhoven, H., Helin, K., Lioi, M. B., Collombat, P., Gecz, J., Altucci, L., Di Schiavi, E., & Miano, M. GI. (2019). Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. Human Molecular Genetics, 28(24), 4089-4102. https://doi.org/10.1093/hmg/ddz254

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. / Poeta, Loredana; Padula, Agnese; Attianese, Benedetta et al.
In: Human Molecular Genetics, Vol. 28, No. 24, 15.12.2019, p. 4089-4102.

Research output: Contribution to journal › Journal article › Research › peer-review

Poeta, L, Padula, A, Attianese, B, Valentino, M, Verrillo, L, Filosa, S, Shoubridge, C, Barra, A, Schwartz, CE, Christensen, J, van Bokhoven, H, Helin, K, Lioi, MB, Collombat, P, Gecz, J, Altucci, L, Di Schiavi, E & Miano, MGI 2019, 'Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders', Human Molecular Genetics, vol. 28, no. 24, pp. 4089-4102. https://doi.org/10.1093/hmg/ddz254

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title = "Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders",

keywords = "LINKED MENTAL-RETARDATION, CONTROLS AXON GUIDANCE, EMBRYONIC STEM-CELLS, INTELLECTUAL DISABILITY, DEACETYLASE INHIBITORS, H3K4 METHYLATION, IMPAIRED REMOVAL, PHF8 GENE, MUTATIONS, BDNF",

author = "Loredana Poeta and Agnese Padula and Benedetta Attianese and Mariaelena Valentino and Lucia Verrillo and Stefania Filosa and Cheryl Shoubridge and Adriano Barra and Schwartz, {Charles E.} and Jesper Christensen and {van Bokhoven}, Hans and Kristian Helin and Lioi, {Maria Brigida} and Patrick Collombat and Jozef Gecz and Lucia Altucci and {Di Schiavi}, Elia and Miano, {Maria GIuseppina}",

year = "2019",

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doi = "10.1093/hmg/ddz254",

language = "English",

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T1 - Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

AU - Poeta, Loredana

AU - Padula, Agnese

AU - Attianese, Benedetta

AU - Valentino, Mariaelena

AU - Verrillo, Lucia

AU - Filosa, Stefania

AU - Shoubridge, Cheryl

AU - Barra, Adriano

AU - Schwartz, Charles E.

AU - Christensen, Jesper

AU - van Bokhoven, Hans

AU - Helin, Kristian

AU - Lioi, Maria Brigida

AU - Collombat, Patrick

AU - Gecz, Jozef

AU - Altucci, Lucia

AU - Di Schiavi, Elia

AU - Miano, Maria GIuseppina

PY - 2019/12/15

Y1 - 2019/12/15

KW - LINKED MENTAL-RETARDATION

KW - CONTROLS AXON GUIDANCE

KW - EMBRYONIC STEM-CELLS

KW - INTELLECTUAL DISABILITY

KW - DEACETYLASE INHIBITORS

KW - H3K4 METHYLATION

KW - IMPAIRED REMOVAL

KW - PHF8 GENE

KW - MUTATIONS

KW - BDNF

U2 - 10.1093/hmg/ddz254

DO - 10.1093/hmg/ddz254

M3 - Journal article

C2 - 31691806

SN - 0964-6906

VL - 28

SP - 4089

EP - 4102

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 24

ER -

Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders

Keywords

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