Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study

Anne Langkilde; Juliette Tavenier; Allan Vestergaard Danielsen; Jesper Eugen-Olsen; Christina Therkildsen; Frank Krieger Jensen; Jens Henrik Henriksen; Henning Langberg; Torben Steiniche; Janne Petersen; Susanne Holck; Ove Andersen

doi:10.1093/infdis/jiy284

Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study

Anne Langkilde, Juliette Tavenier, Allan Vestergaard Danielsen, Jesper Eugen-Olsen, Christina Therkildsen, Frank Krieger Jensen, Jens Henrik Henriksen, Henning Langberg, Torben Steiniche, Janne Petersen, Susanne Holck, Ove Andersen

2 Citations (Scopus)

Abstract

Background: In HIV-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy.

Methods: A cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. We evaluated lipodystrophy (clinical assessment) and metabolic syndrome (JIS-2009). We compared adipocyte size, leukocyte infiltration, and gene expression in abdominal subcutaneous adipose tissue biopsies of patients with and without lipodystrophy, and with and without metabolic syndrome.

Results: Lipodystrophy was only associated with increased macrophage infiltration (P=0.04) and adiponectin mRNA (P=0.008), whereas metabolic syndrome was associated with larger adipocytes (P<0.0001), decreased expression of genes related to adipogenesis and adipocyte function (P-values between <0.0001-0.08), increased leptin mRNA (P=0.04), and a trend towards increased expression of inflammatory genes (P-values between 0.08-0.6).

Conclusions: Metabolic syndrome rather than lipodystrophy was associated with major unfavourable abdominal subcutaneous adipose tissue changes. In a clinical setting, it may be more relevant to focus on metabolic syndrome diagnosis in HIV-infected patients on cART with regards to adipose tissue dysfunction and risk of cardio-metabolic complications.

Original language	English
Journal	The Journal of Infectious Diseases
Volume	218
Issue number	7
Pages (from-to)	1090-1098
Number of pages	9
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiy284
Publication status	Published - 2018

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Langkilde, A., Tavenier, J., Danielsen, A. V., Eugen-Olsen, J., Therkildsen, C., Jensen, F. K., Henriksen, J. H., Langberg, H., Steiniche, T., Petersen, J., Holck, S., & Andersen, O. (2018). Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study. The Journal of Infectious Diseases, 218(7), 1090-1098. https://doi.org/10.1093/infdis/jiy284

Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study. / Langkilde, Anne; Tavenier, Juliette; Danielsen, Allan Vestergaard et al.
In: The Journal of Infectious Diseases, Vol. 218, No. 7, 2018, p. 1090-1098.

Research output: Contribution to journal › Journal article › Research › peer-review

Langkilde, A, Tavenier, J, Danielsen, AV, Eugen-Olsen, J, Therkildsen, C, Jensen, FK, Henriksen, JH, Langberg, H, Steiniche, T, Petersen, J, Holck, S & Andersen, O 2018, 'Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study', The Journal of Infectious Diseases, vol. 218, no. 7, pp. 1090-1098. https://doi.org/10.1093/infdis/jiy284

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title = "Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study",

abstract = "Background: In HIV-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy.Methods: A cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. We evaluated lipodystrophy (clinical assessment) and metabolic syndrome (JIS-2009). We compared adipocyte size, leukocyte infiltration, and gene expression in abdominal subcutaneous adipose tissue biopsies of patients with and without lipodystrophy, and with and without metabolic syndrome.Results: Lipodystrophy was only associated with increased macrophage infiltration (P=0.04) and adiponectin mRNA (P=0.008), whereas metabolic syndrome was associated with larger adipocytes (P<0.0001), decreased expression of genes related to adipogenesis and adipocyte function (P-values between <0.0001-0.08), increased leptin mRNA (P=0.04), and a trend towards increased expression of inflammatory genes (P-values between 0.08-0.6).Conclusions: Metabolic syndrome rather than lipodystrophy was associated with major unfavourable abdominal subcutaneous adipose tissue changes. In a clinical setting, it may be more relevant to focus on metabolic syndrome diagnosis in HIV-infected patients on cART with regards to adipose tissue dysfunction and risk of cardio-metabolic complications.",

author = "Anne Langkilde and Juliette Tavenier and Danielsen, {Allan Vestergaard} and Jesper Eugen-Olsen and Christina Therkildsen and Jensen, {Frank Krieger} and Henriksen, {Jens Henrik} and Henning Langberg and Torben Steiniche and Janne Petersen and Susanne Holck and Ove Andersen",

year = "2018",

doi = "10.1093/infdis/jiy284",

language = "English",

volume = "218",

pages = "1090--1098",

journal = "The Journal of Infectious Diseases",

issn = "0022-1899",

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T1 - Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study

AU - Langkilde, Anne

AU - Tavenier, Juliette

AU - Danielsen, Allan Vestergaard

AU - Eugen-Olsen, Jesper

AU - Therkildsen, Christina

AU - Jensen, Frank Krieger

AU - Henriksen, Jens Henrik

AU - Langberg, Henning

AU - Steiniche, Torben

AU - Petersen, Janne

AU - Holck, Susanne

AU - Andersen, Ove

PY - 2018

Y1 - 2018

N2 - Background: In HIV-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy.Methods: A cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. We evaluated lipodystrophy (clinical assessment) and metabolic syndrome (JIS-2009). We compared adipocyte size, leukocyte infiltration, and gene expression in abdominal subcutaneous adipose tissue biopsies of patients with and without lipodystrophy, and with and without metabolic syndrome.Results: Lipodystrophy was only associated with increased macrophage infiltration (P=0.04) and adiponectin mRNA (P=0.008), whereas metabolic syndrome was associated with larger adipocytes (P<0.0001), decreased expression of genes related to adipogenesis and adipocyte function (P-values between <0.0001-0.08), increased leptin mRNA (P=0.04), and a trend towards increased expression of inflammatory genes (P-values between 0.08-0.6).Conclusions: Metabolic syndrome rather than lipodystrophy was associated with major unfavourable abdominal subcutaneous adipose tissue changes. In a clinical setting, it may be more relevant to focus on metabolic syndrome diagnosis in HIV-infected patients on cART with regards to adipose tissue dysfunction and risk of cardio-metabolic complications.

AB - Background: In HIV-infected patients on combination antiretroviral therapy (cART), lipodystrophy shares many similarities with metabolic syndrome, but only metabolic syndrome has objective classification criteria. We examined adipose tissue changes related to lipodystrophy and metabolic syndrome to clarify whether it may be acceptable to focus diagnosis on metabolic syndrome rather than lipodystrophy.Methods: A cross-sectional study of 60 HIV-infected men on cART and 15 healthy men. We evaluated lipodystrophy (clinical assessment) and metabolic syndrome (JIS-2009). We compared adipocyte size, leukocyte infiltration, and gene expression in abdominal subcutaneous adipose tissue biopsies of patients with and without lipodystrophy, and with and without metabolic syndrome.Results: Lipodystrophy was only associated with increased macrophage infiltration (P=0.04) and adiponectin mRNA (P=0.008), whereas metabolic syndrome was associated with larger adipocytes (P<0.0001), decreased expression of genes related to adipogenesis and adipocyte function (P-values between <0.0001-0.08), increased leptin mRNA (P=0.04), and a trend towards increased expression of inflammatory genes (P-values between 0.08-0.6).Conclusions: Metabolic syndrome rather than lipodystrophy was associated with major unfavourable abdominal subcutaneous adipose tissue changes. In a clinical setting, it may be more relevant to focus on metabolic syndrome diagnosis in HIV-infected patients on cART with regards to adipose tissue dysfunction and risk of cardio-metabolic complications.

U2 - 10.1093/infdis/jiy284

DO - 10.1093/infdis/jiy284

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C2 - 29788076

SN - 0022-1899

VL - 218

SP - 1090

EP - 1098

JO - The Journal of Infectious Diseases

JF - The Journal of Infectious Diseases

IS - 7

ER -

Histological and Molecular Adipose Tissue Changes are related to Metabolic Syndrome rather than Lipodystrophy in HIV-infected Patients-A Cross-Sectional Study

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