Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children

Rasmus Wibæk Christensen; Tsinuel Girma; Bitiya Admassu Wossen; Mubarek Abera Mengistie; Alemseged Abdissa; Zeleke Geto; Pernille Kæstel; Dorte Vistisen; Marit Eika Jørgensen; Jonathan C K Wells; Kim F. Michaelsen; Henrik Friis; Gregers Stig Andersen

doi:10.1093/jn/nxz121

Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children

Rasmus Wibæk Christensen, Tsinuel Girma, Bitiya Admassu Wossen, Mubarek Abera Mengistie, Alemseged Abdissa, Zeleke Geto, Pernille Kæstel, Dorte Vistisen, Marit Eika Jørgensen, Jonathan C K Wells, Kim F. Michaelsen, Henrik Friis, Gregers Stig Andersen

Lifecourse Nutrition & Health

Abstract

Background: Fetal and early life growth is associated with adult risk of obesity and cardiometabolic disease. However, little is known about the relative importance of birth weight and successive periods of weight gain on markers of cardiometabolic risk in childhood in low-income populations. Objectives: The objective was to study associations of birth weight and weight gain velocities in selected age intervals from birth to 60 mo with height, fat-free mass (FFM), and markers of adiposity and cardiometabolic risk at 60 mo. Methods: In a prospective cohort study of 375 Ethiopian children aged 60 mo, we estimated individual weight gain velocities in the periods between birth and 3, 6, 24, 48, and 60 mo using linear-spline mixed-effects modeling. Subsequently, we analyzed associations of birth weight, weight gain velocities, and current weight with height, FFM, and markers of adiposity and cardiometabolic risk. Results: Weight gain from 48 to 60 mo and weight at 60 mo rather than birth weight were the strongest correlates of insulin, C-peptide, HOMA-IR, blood pressure, height, FFM, waist circumference, and fat mass at 60 mo. For instance, 1 SD higher (1 SD = 50 g/mo) weight accretion from 48 to 60 mo was associated with a higher insulin of 23.3% (95% CI: 9.6%, 38.8%), C-peptide of 11.4% (2.7%, 20.8%), systolic blood pressure of 1.4 mm Hg (0.6, 2.3 mm Hg), fat mass of 0.72 kg (0.59, 0.85 kg), and FFM of 0.70 kg (0.56, 0.85 kg). Weight gain from 0 to 3 mo was positively associated with LDL cholesterol, systolic blood pressure, height, and the body composition indices, and weight gain from 24 to 48 mo was inversely associated with blood glucose. Conclusions: In 60-mo-old Ethiopian urban children, weight gain and weight after 48 mo rather than weight at birth may represent a sensitive period for variations in markers of adiposity and glucose metabolism.

Original language	English
Journal	Journal of Nutrition
Volume	149
Issue number	10
Pages (from-to)	1785-1796
Number of pages	15
ISSN	0022-3166
DOIs	https://doi.org/10.1093/jn/nxz121
Publication status	Published - 1 Oct 2019

Keywords

Faculty of Science
Birth weight
Body composition
Cardiometabolic status
Cohort study
Child
Developmental origins of health and disease
Ethiopia
Growth
Infant
Linear-spline mixed-effects model

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Wibæk Christensen, R., Girma, T., Admassu Wossen, B., Abera Mengistie, M., Abdissa, A., Geto, Z., Kæstel, P., Vistisen, D., Jørgensen, M. E., Wells, J. C. K., Michaelsen, K. F., Friis, H., & Andersen, G. S. (2019). Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children. Journal of Nutrition, 149(10), 1785-1796. https://doi.org/10.1093/jn/nxz121

Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children. / Wibæk Christensen, Rasmus; Girma, Tsinuel; Admassu Wossen, Bitiya et al.
In: Journal of Nutrition, Vol. 149, No. 10, 01.10.2019, p. 1785-1796.

Research output: Contribution to journal › Journal article › Research › peer-review

Wibæk Christensen, R, Girma, T, Admassu Wossen, B, Abera Mengistie, M, Abdissa, A, Geto, Z, Kæstel, P, Vistisen, D, Jørgensen, ME, Wells, JCK, Michaelsen, KF , Friis, H & Andersen, GS 2019, 'Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children', Journal of Nutrition, vol. 149, no. 10, pp. 1785-1796. https://doi.org/10.1093/jn/nxz121

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title = "Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children",

abstract = "Background: Fetal and early life growth is associated with adult risk of obesity and cardiometabolic disease. However, little is known about the relative importance of birth weight and successive periods of weight gain on markers of cardiometabolic risk in childhood in low-income populations. Objectives: The objective was to study associations of birth weight and weight gain velocities in selected age intervals from birth to 60 mo with height, fat-free mass (FFM), and markers of adiposity and cardiometabolic risk at 60 mo. Methods: In a prospective cohort study of 375 Ethiopian children aged 60 mo, we estimated individual weight gain velocities in the periods between birth and 3, 6, 24, 48, and 60 mo using linear-spline mixed-effects modeling. Subsequently, we analyzed associations of birth weight, weight gain velocities, and current weight with height, FFM, and markers of adiposity and cardiometabolic risk. Results: Weight gain from 48 to 60 mo and weight at 60 mo rather than birth weight were the strongest correlates of insulin, C-peptide, HOMA-IR, blood pressure, height, FFM, waist circumference, and fat mass at 60 mo. For instance, 1 SD higher (1 SD = 50 g/mo) weight accretion from 48 to 60 mo was associated with a higher insulin of 23.3% (95% CI: 9.6%, 38.8%), C-peptide of 11.4% (2.7%, 20.8%), systolic blood pressure of 1.4 mm Hg (0.6, 2.3 mm Hg), fat mass of 0.72 kg (0.59, 0.85 kg), and FFM of 0.70 kg (0.56, 0.85 kg). Weight gain from 0 to 3 mo was positively associated with LDL cholesterol, systolic blood pressure, height, and the body composition indices, and weight gain from 24 to 48 mo was inversely associated with blood glucose. Conclusions: In 60-mo-old Ethiopian urban children, weight gain and weight after 48 mo rather than weight at birth may represent a sensitive period for variations in markers of adiposity and glucose metabolism.",

keywords = "Faculty of Science, Birth weight, Body composition, Cardiometabolic status, Cohort study, Child, Developmental origins of health and disease, Ethiopia, Growth, Infant, Linear-spline mixed-effects model",

author = "{Wib{\ae}k Christensen}, Rasmus and Tsinuel Girma and {Admassu Wossen}, Bitiya and {Abera Mengistie}, Mubarek and Alemseged Abdissa and Zeleke Geto and Pernille K{\ae}stel and Dorte Vistisen and J{\o}rgensen, {Marit Eika} and Wells, {Jonathan C K} and Michaelsen, {Kim F.} and Henrik Friis and Andersen, {Gregers Stig}",

note = "Copyright {\textcopyright} American Society for Nutrition 2019.",

year = "2019",

month = oct,

day = "1",

doi = "10.1093/jn/nxz121",

language = "English",

volume = "149",

pages = "1785--1796",

journal = "Journal of Nutrition",

issn = "0022-3166",

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TY - JOUR

T1 - Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children

AU - Wibæk Christensen, Rasmus

AU - Girma, Tsinuel

AU - Admassu Wossen, Bitiya

AU - Abera Mengistie, Mubarek

AU - Abdissa, Alemseged

AU - Geto, Zeleke

AU - Kæstel, Pernille

AU - Vistisen, Dorte

AU - Jørgensen, Marit Eika

AU - Wells, Jonathan C K

AU - Michaelsen, Kim F.

AU - Friis, Henrik

AU - Andersen, Gregers Stig

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Fetal and early life growth is associated with adult risk of obesity and cardiometabolic disease. However, little is known about the relative importance of birth weight and successive periods of weight gain on markers of cardiometabolic risk in childhood in low-income populations. Objectives: The objective was to study associations of birth weight and weight gain velocities in selected age intervals from birth to 60 mo with height, fat-free mass (FFM), and markers of adiposity and cardiometabolic risk at 60 mo. Methods: In a prospective cohort study of 375 Ethiopian children aged 60 mo, we estimated individual weight gain velocities in the periods between birth and 3, 6, 24, 48, and 60 mo using linear-spline mixed-effects modeling. Subsequently, we analyzed associations of birth weight, weight gain velocities, and current weight with height, FFM, and markers of adiposity and cardiometabolic risk. Results: Weight gain from 48 to 60 mo and weight at 60 mo rather than birth weight were the strongest correlates of insulin, C-peptide, HOMA-IR, blood pressure, height, FFM, waist circumference, and fat mass at 60 mo. For instance, 1 SD higher (1 SD = 50 g/mo) weight accretion from 48 to 60 mo was associated with a higher insulin of 23.3% (95% CI: 9.6%, 38.8%), C-peptide of 11.4% (2.7%, 20.8%), systolic blood pressure of 1.4 mm Hg (0.6, 2.3 mm Hg), fat mass of 0.72 kg (0.59, 0.85 kg), and FFM of 0.70 kg (0.56, 0.85 kg). Weight gain from 0 to 3 mo was positively associated with LDL cholesterol, systolic blood pressure, height, and the body composition indices, and weight gain from 24 to 48 mo was inversely associated with blood glucose. Conclusions: In 60-mo-old Ethiopian urban children, weight gain and weight after 48 mo rather than weight at birth may represent a sensitive period for variations in markers of adiposity and glucose metabolism.

AB - Background: Fetal and early life growth is associated with adult risk of obesity and cardiometabolic disease. However, little is known about the relative importance of birth weight and successive periods of weight gain on markers of cardiometabolic risk in childhood in low-income populations. Objectives: The objective was to study associations of birth weight and weight gain velocities in selected age intervals from birth to 60 mo with height, fat-free mass (FFM), and markers of adiposity and cardiometabolic risk at 60 mo. Methods: In a prospective cohort study of 375 Ethiopian children aged 60 mo, we estimated individual weight gain velocities in the periods between birth and 3, 6, 24, 48, and 60 mo using linear-spline mixed-effects modeling. Subsequently, we analyzed associations of birth weight, weight gain velocities, and current weight with height, FFM, and markers of adiposity and cardiometabolic risk. Results: Weight gain from 48 to 60 mo and weight at 60 mo rather than birth weight were the strongest correlates of insulin, C-peptide, HOMA-IR, blood pressure, height, FFM, waist circumference, and fat mass at 60 mo. For instance, 1 SD higher (1 SD = 50 g/mo) weight accretion from 48 to 60 mo was associated with a higher insulin of 23.3% (95% CI: 9.6%, 38.8%), C-peptide of 11.4% (2.7%, 20.8%), systolic blood pressure of 1.4 mm Hg (0.6, 2.3 mm Hg), fat mass of 0.72 kg (0.59, 0.85 kg), and FFM of 0.70 kg (0.56, 0.85 kg). Weight gain from 0 to 3 mo was positively associated with LDL cholesterol, systolic blood pressure, height, and the body composition indices, and weight gain from 24 to 48 mo was inversely associated with blood glucose. Conclusions: In 60-mo-old Ethiopian urban children, weight gain and weight after 48 mo rather than weight at birth may represent a sensitive period for variations in markers of adiposity and glucose metabolism.

KW - Faculty of Science

KW - Birth weight

KW - Body composition

KW - Cardiometabolic status

KW - Cohort study

KW - Child

KW - Developmental origins of health and disease

KW - Ethiopia

KW - Growth

KW - Infant

KW - Linear-spline mixed-effects model

U2 - 10.1093/jn/nxz121

DO - 10.1093/jn/nxz121

M3 - Journal article

C2 - 31218356

SN - 0022-3166

VL - 149

SP - 1785

EP - 1796

JO - Journal of Nutrition

JF - Journal of Nutrition

IS - 10

ER -

Higher weight and weight gain after 4 years of age rather than weight at birth are associated with adiposity, markers of glucose metabolism, and blood pressure in 5-year-old Ethiopian children

Abstract

Keywords

UN SDGs

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