Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study

Mads Vendelbo Lind; Lotte Lauritzen; Oluf Borbye Pedersen; Henrik Vestergaard; Ken D Stark; Torben Hansen; Alastair B. Ross; Mette Bredal Kristensen

doi:10.1016/j.nutres.2017.09.008

Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study

Mads Vendelbo Lind, Lotte Lauritzen, Oluf Borbye Pedersen, Henrik Vestergaard, Ken D Stark, Torben Hansen, Alastair B. Ross, Mette Bredal Kristensen

Abstract

Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B12 was included as one-carbon metabolism markers. We used principal component analysis (PCA) to explore dietary patterns and multiple linear regression models to examine associations between dietary factors and one-carbon metabolites. PCA separated subjects based on prudent and unhealthy dietary patterns, but the dietary pattern score was not related to the one-carbon metabolites. Whole grain intake was found to be inversely associated to plasma Hcy (-4.7% (-9.3; 0.0), P=.05) and total grain intake tended to be positively associated with SAM and SAH (2.4% (-0.5; 5.5), P=.08; 5.8% (-0.2; 12.1), P=.06, respectively, per SD increase in cereal intake). Fish intake was inversely associated with plasma Hcy and SAH concentrations (-5.4% (-9.7; -0.8), P=.02 and -7.0% (-12.1; -1.5), P=.01, respectively) and positively associated with the SAM:SAH ratio (6.2% (1.6; 11.0), P=.008). In conclusion, intake and fish and whole-grain appear to be associated with a beneficial one-carbon metabolism profile. This indicates that dietary components could play a role in regulation of one-carbon metabolism with a potential impact on disease prevention.

Original language	English
Journal	Nutrition Research
Volume	46
Pages (from-to)	78-87
Number of pages	10
ISSN	0271-5317
DOIs	https://doi.org/10.1016/j.nutres.2017.09.008
Publication status	Published - Oct 2017

Keywords

Dietary patterns
Homocysteine
Long-chain polyunsaturated fatty acids
Whole grain
Methyl donor metabolism

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10.1016/j.nutres.2017.09.008

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@article{cd618ea892c043e3bf9586f466394fbf,

title = "Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study",

abstract = "Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B12 was included as one-carbon metabolism markers. We used principal component analysis (PCA) to explore dietary patterns and multiple linear regression models to examine associations between dietary factors and one-carbon metabolites. PCA separated subjects based on prudent and unhealthy dietary patterns, but the dietary pattern score was not related to the one-carbon metabolites. Whole grain intake was found to be inversely associated to plasma Hcy (-4.7% (-9.3; 0.0), P=.05) and total grain intake tended to be positively associated with SAM and SAH (2.4% (-0.5; 5.5), P=.08; 5.8% (-0.2; 12.1), P=.06, respectively, per SD increase in cereal intake). Fish intake was inversely associated with plasma Hcy and SAH concentrations (-5.4% (-9.7; -0.8), P=.02 and -7.0% (-12.1; -1.5), P=.01, respectively) and positively associated with the SAM:SAH ratio (6.2% (1.6; 11.0), P=.008). In conclusion, intake and fish and whole-grain appear to be associated with a beneficial one-carbon metabolism profile. This indicates that dietary components could play a role in regulation of one-carbon metabolism with a potential impact on disease prevention.",

keywords = "Dietary patterns, Homocysteine, Long-chain polyunsaturated fatty acids, Whole grain, Methyl donor metabolism",

author = "Lind, {Mads Vendelbo} and Lotte Lauritzen and Pedersen, {Oluf Borbye} and Henrik Vestergaard and Stark, {Ken D} and Torben Hansen and Ross, {Alastair B.} and Kristensen, {Mette Bredal}",

note = "CURIS 2017 NEXS 312",

year = "2017",

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doi = "10.1016/j.nutres.2017.09.008",

language = "English",

volume = "46",

pages = "78--87",

journal = "Nutrition Research",

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TY - JOUR

T1 - Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine

T2 - a cross-sectional study

AU - Lind, Mads Vendelbo

AU - Lauritzen, Lotte

AU - Pedersen, Oluf Borbye

AU - Vestergaard, Henrik

AU - Stark, Ken D

AU - Hansen, Torben

AU - Ross, Alastair B.

AU - Kristensen, Mette Bredal

N1 - CURIS 2017 NEXS 312

PY - 2017/10

Y1 - 2017/10

N2 - Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B12 was included as one-carbon metabolism markers. We used principal component analysis (PCA) to explore dietary patterns and multiple linear regression models to examine associations between dietary factors and one-carbon metabolites. PCA separated subjects based on prudent and unhealthy dietary patterns, but the dietary pattern score was not related to the one-carbon metabolites. Whole grain intake was found to be inversely associated to plasma Hcy (-4.7% (-9.3; 0.0), P=.05) and total grain intake tended to be positively associated with SAM and SAH (2.4% (-0.5; 5.5), P=.08; 5.8% (-0.2; 12.1), P=.06, respectively, per SD increase in cereal intake). Fish intake was inversely associated with plasma Hcy and SAH concentrations (-5.4% (-9.7; -0.8), P=.02 and -7.0% (-12.1; -1.5), P=.01, respectively) and positively associated with the SAM:SAH ratio (6.2% (1.6; 11.0), P=.008). In conclusion, intake and fish and whole-grain appear to be associated with a beneficial one-carbon metabolism profile. This indicates that dietary components could play a role in regulation of one-carbon metabolism with a potential impact on disease prevention.

AB - Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome. In addition we assessed whole-blood fatty acid composition and plasma alkylresorcinols. Plasma s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH), homocysteine (Hcy) and vitamin B12 was included as one-carbon metabolism markers. We used principal component analysis (PCA) to explore dietary patterns and multiple linear regression models to examine associations between dietary factors and one-carbon metabolites. PCA separated subjects based on prudent and unhealthy dietary patterns, but the dietary pattern score was not related to the one-carbon metabolites. Whole grain intake was found to be inversely associated to plasma Hcy (-4.7% (-9.3; 0.0), P=.05) and total grain intake tended to be positively associated with SAM and SAH (2.4% (-0.5; 5.5), P=.08; 5.8% (-0.2; 12.1), P=.06, respectively, per SD increase in cereal intake). Fish intake was inversely associated with plasma Hcy and SAH concentrations (-5.4% (-9.7; -0.8), P=.02 and -7.0% (-12.1; -1.5), P=.01, respectively) and positively associated with the SAM:SAH ratio (6.2% (1.6; 11.0), P=.008). In conclusion, intake and fish and whole-grain appear to be associated with a beneficial one-carbon metabolism profile. This indicates that dietary components could play a role in regulation of one-carbon metabolism with a potential impact on disease prevention.

KW - Dietary patterns

KW - Homocysteine

KW - Long-chain polyunsaturated fatty acids

KW - Whole grain

KW - Methyl donor metabolism

U2 - 10.1016/j.nutres.2017.09.008

DO - 10.1016/j.nutres.2017.09.008

M3 - Journal article

C2 - 29129471

SN - 0271-5317

VL - 46

SP - 78

EP - 87

JO - Nutrition Research

JF - Nutrition Research

ER -

Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study

Abstract

Keywords

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