High YKL-40 levels predict mortality in patients with type 2 diabetes

Frederik Persson; Camilla Noelle Rathcke; Mari-Anne Gall; Hans-Henrik Parving; Henrik Vestergaard; Peter Rossing

doi:10.1016/j.diabres.2011.12.008

High YKL-40 levels predict mortality in patients with type 2 diabetes

Frederik Persson, Camilla Noelle Rathcke, Mari-Anne Gall, Hans-Henrik Parving, Henrik Vestergaard, Peter Rossing

31 Citations (Scopus)

Abstract

Aims: We determined levels of the inflammatory marker YKL-40 in a population of patients with type 2 diabetes (T2D) and investigated the association with mortality. Methods: In a prospective observational follow-up study, 290 patients with T2D, normoalbuminuria (. n=. 177), microalbuminuria (. n=. 71) and macroalbuminuria (. n=. 42) were followed for a median (range) of 17.2 (0.2-23.0) years. Serum YKL-40 concentration was determined at baseline. Results: Baseline median (IQR) YKL-40 level was 46. ng/ml (36-67) in patients with normoalbuminuria, 61. ng/ml (43-114) in microalbuminuric patients, and 81.5. ng/ml (60-157) in patients with macroalbuminuria, . p<. 0.001. During follow-up 189 patients (65.2%) died, 119 (41.0%) from cardiovascular causes. All-cause mortality was increased in patients with YKL-40 levels in the second and third tertile (hazard ratios (95% CI) compared with the first tertile, (1.50 (1.03-2.19), . p=. 0.034, and 2.88 (2.01-4.12), . p<. 0.001). This association persisted after adjustment for cardiovascular risk factors but was attenuated after additional adjustment for urinary albumin excretion rate and glomerular filtration rate.Cardiovascular mortality was increased with YKL-40 levels in the third tertile compared with the first tertile, (2.70 (1.78-4.08)), . p<. 0.001. This association was diminished after adjustment for covariates. Conclusions: In patients with T2D and increasing albuminuria high YKL-40 levels predict all-cause mortality.

Original language	English
Journal	Diabetes Research and Clinical Practice
Volume	96
Issue number	1
Pages (from-to)	84-9
Number of pages	6
ISSN	0168-8227
DOIs	https://doi.org/10.1016/j.diabres.2011.12.008
Publication status	Published - Apr 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.diabres.2011.12.008

Cite this

@article{fb58626d75bc4d8e86647a630b77a597,

title = "High YKL-40 levels predict mortality in patients with type 2 diabetes",

abstract = "Aims: We determined levels of the inflammatory marker YKL-40 in a population of patients with type 2 diabetes (T2D) and investigated the association with mortality. Methods: In a prospective observational follow-up study, 290 patients with T2D, normoalbuminuria (. n=. 177), microalbuminuria (. n=. 71) and macroalbuminuria (. n=. 42) were followed for a median (range) of 17.2 (0.2-23.0) years. Serum YKL-40 concentration was determined at baseline. Results: Baseline median (IQR) YKL-40 level was 46. ng/ml (36-67) in patients with normoalbuminuria, 61. ng/ml (43-114) in microalbuminuric patients, and 81.5. ng/ml (60-157) in patients with macroalbuminuria, . p<. 0.001. During follow-up 189 patients (65.2%) died, 119 (41.0%) from cardiovascular causes. All-cause mortality was increased in patients with YKL-40 levels in the second and third tertile (hazard ratios (95% CI) compared with the first tertile, (1.50 (1.03-2.19), . p=. 0.034, and 2.88 (2.01-4.12), . p<. 0.001). This association persisted after adjustment for cardiovascular risk factors but was attenuated after additional adjustment for urinary albumin excretion rate and glomerular filtration rate.Cardiovascular mortality was increased with YKL-40 levels in the third tertile compared with the first tertile, (2.70 (1.78-4.08)), . p<. 0.001. This association was diminished after adjustment for covariates. Conclusions: In patients with T2D and increasing albuminuria high YKL-40 levels predict all-cause mortality.",

author = "Frederik Persson and Rathcke, {Camilla Noelle} and Mari-Anne Gall and Hans-Henrik Parving and Henrik Vestergaard and Peter Rossing",

year = "2012",

month = apr,

doi = "10.1016/j.diabres.2011.12.008",

language = "English",

volume = "96",

pages = "84--9",

journal = "Diabetes Research and Clinical Practice",

issn = "0168-8227",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - High YKL-40 levels predict mortality in patients with type 2 diabetes

AU - Persson, Frederik

AU - Rathcke, Camilla Noelle

AU - Gall, Mari-Anne

AU - Parving, Hans-Henrik

AU - Vestergaard, Henrik

AU - Rossing, Peter

PY - 2012/4

Y1 - 2012/4

N2 - Aims: We determined levels of the inflammatory marker YKL-40 in a population of patients with type 2 diabetes (T2D) and investigated the association with mortality. Methods: In a prospective observational follow-up study, 290 patients with T2D, normoalbuminuria (. n=. 177), microalbuminuria (. n=. 71) and macroalbuminuria (. n=. 42) were followed for a median (range) of 17.2 (0.2-23.0) years. Serum YKL-40 concentration was determined at baseline. Results: Baseline median (IQR) YKL-40 level was 46. ng/ml (36-67) in patients with normoalbuminuria, 61. ng/ml (43-114) in microalbuminuric patients, and 81.5. ng/ml (60-157) in patients with macroalbuminuria, . p<. 0.001. During follow-up 189 patients (65.2%) died, 119 (41.0%) from cardiovascular causes. All-cause mortality was increased in patients with YKL-40 levels in the second and third tertile (hazard ratios (95% CI) compared with the first tertile, (1.50 (1.03-2.19), . p=. 0.034, and 2.88 (2.01-4.12), . p<. 0.001). This association persisted after adjustment for cardiovascular risk factors but was attenuated after additional adjustment for urinary albumin excretion rate and glomerular filtration rate.Cardiovascular mortality was increased with YKL-40 levels in the third tertile compared with the first tertile, (2.70 (1.78-4.08)), . p<. 0.001. This association was diminished after adjustment for covariates. Conclusions: In patients with T2D and increasing albuminuria high YKL-40 levels predict all-cause mortality.

AB - Aims: We determined levels of the inflammatory marker YKL-40 in a population of patients with type 2 diabetes (T2D) and investigated the association with mortality. Methods: In a prospective observational follow-up study, 290 patients with T2D, normoalbuminuria (. n=. 177), microalbuminuria (. n=. 71) and macroalbuminuria (. n=. 42) were followed for a median (range) of 17.2 (0.2-23.0) years. Serum YKL-40 concentration was determined at baseline. Results: Baseline median (IQR) YKL-40 level was 46. ng/ml (36-67) in patients with normoalbuminuria, 61. ng/ml (43-114) in microalbuminuric patients, and 81.5. ng/ml (60-157) in patients with macroalbuminuria, . p<. 0.001. During follow-up 189 patients (65.2%) died, 119 (41.0%) from cardiovascular causes. All-cause mortality was increased in patients with YKL-40 levels in the second and third tertile (hazard ratios (95% CI) compared with the first tertile, (1.50 (1.03-2.19), . p=. 0.034, and 2.88 (2.01-4.12), . p<. 0.001). This association persisted after adjustment for cardiovascular risk factors but was attenuated after additional adjustment for urinary albumin excretion rate and glomerular filtration rate.Cardiovascular mortality was increased with YKL-40 levels in the third tertile compared with the first tertile, (2.70 (1.78-4.08)), . p<. 0.001. This association was diminished after adjustment for covariates. Conclusions: In patients with T2D and increasing albuminuria high YKL-40 levels predict all-cause mortality.

U2 - 10.1016/j.diabres.2011.12.008

DO - 10.1016/j.diabres.2011.12.008

M3 - Journal article

C2 - 22209020

SN - 0168-8227

VL - 96

SP - 84

EP - 89

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

IS - 1

ER -

High YKL-40 levels predict mortality in patients with type 2 diabetes

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this