High versus standard magnetic resonance image resolution of the cervical spine in patients with axial spondyloarthritis

Simon Krabbe; Mikkel Østergaard; Inge J. Sørensen; Jakob Møller; Bente Jensen; Ole R. Madsen; Susanne J. Pedersen

doi:10.1177/0284185119872689

High versus standard magnetic resonance image resolution of the cervical spine in patients with axial spondyloarthritis

Simon Krabbe^*, Mikkel Østergaard, Inge J. Sørensen, Jakob Møller, Bente Jensen, Ole R. Madsen, Susanne J. Pedersen

^*Corresponding author for this work

Abstract

Background: Sagittal magnetic resonance (MR) images are typically obtained with the same spatial resolution along the entire spine, but cervical vertebrae are smaller and may be harder to assess. Purpose: To investigate if high-resolution (high-res) short tau inversion recovery (STIR) and T1-weighted turbo spin echo (T1W) MR imaging (MRI) sequences are superior to standard resolution for detecting inflammatory and structural lesions in the cervical spine of patients with axial spondyloarthritis. Material and Methods: Images were obtained in 36 patients. Voxel sizes at high/standard resolution were 1.99/4.33 mm³ (STIR) and 0.89/3.71 mm³ (T1W). High-resolution and standard-resolution images were scored by two readers according to the Canada-Denmark (CANDEN) MRI spine scoring system. Results: Higher bone marrow edema scores were obtained at high resolution versus standard resolution (mean 2.1 vs. 1.2, P = 0.040), whereas fat lesion scores (1.8 vs. 1.5, P = 0.27) and new bone formation scores (3.5 vs. 2.8, P = 0.21) were similar. High-resolution MRI did not classify more patients as positive for bone marrow edema, fat, or new bone formation in the cervical spine compared to standard resolution. Using lateral radiographs as reference standard, sensitivity for detecting anterior corner syndesmophytes with both high-resolution and standard-resolution MRI was low (range 7–22%) and sensitivity for detecting ankylosis was low to moderate (20–55%), while specificity was high (≥96%). Conclusion: High-resolution MRI allowed identification of more inflammatory lesions in the cervical spine in patients with axial spondyloarthritis when compared to standard resolution, but it did not classify more patients as positive for bone marrow edema. The slightly increased sensitivity at high-resolution MRI seemed to be too modest to have any real clinical importance.

Original language	English
Journal	Acta Radiologica
ISSN	0284-1851
DOIs	https://doi.org/10.1177/0284185119872689
Publication status	Published - 1 Apr 2020

Keywords

cervical vertebrae
inflammation
Magnetic resonance imaging
spine
spondyloarthropathies

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10.1177/0284185119872689

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@article{b9952e1a8f32496cb204e5877753c103,

title = "High versus standard magnetic resonance image resolution of the cervical spine in patients with axial spondyloarthritis",

abstract = "Background: Sagittal magnetic resonance (MR) images are typically obtained with the same spatial resolution along the entire spine, but cervical vertebrae are smaller and may be harder to assess. Purpose: To investigate if high-resolution (high-res) short tau inversion recovery (STIR) and T1-weighted turbo spin echo (T1W) MR imaging (MRI) sequences are superior to standard resolution for detecting inflammatory and structural lesions in the cervical spine of patients with axial spondyloarthritis. Material and Methods: Images were obtained in 36 patients. Voxel sizes at high/standard resolution were 1.99/4.33 mm3 (STIR) and 0.89/3.71 mm3 (T1W). High-resolution and standard-resolution images were scored by two readers according to the Canada-Denmark (CANDEN) MRI spine scoring system. Results: Higher bone marrow edema scores were obtained at high resolution versus standard resolution (mean 2.1 vs. 1.2, P = 0.040), whereas fat lesion scores (1.8 vs. 1.5, P = 0.27) and new bone formation scores (3.5 vs. 2.8, P = 0.21) were similar. High-resolution MRI did not classify more patients as positive for bone marrow edema, fat, or new bone formation in the cervical spine compared to standard resolution. Using lateral radiographs as reference standard, sensitivity for detecting anterior corner syndesmophytes with both high-resolution and standard-resolution MRI was low (range 7–22%) and sensitivity for detecting ankylosis was low to moderate (20–55%), while specificity was high (≥96%). Conclusion: High-resolution MRI allowed identification of more inflammatory lesions in the cervical spine in patients with axial spondyloarthritis when compared to standard resolution, but it did not classify more patients as positive for bone marrow edema. The slightly increased sensitivity at high-resolution MRI seemed to be too modest to have any real clinical importance.",

keywords = "cervical vertebrae, inflammation, Magnetic resonance imaging, spine, spondyloarthropathies",

author = "Simon Krabbe and Mikkel {\O}stergaard and S{\o}rensen, {Inge J.} and Jakob M{\o}ller and Bente Jensen and Madsen, {Ole R.} and Pedersen, {Susanne J.}",

year = "2020",

month = apr,

day = "1",

doi = "10.1177/0284185119872689",

language = "English",

journal = "Acta Radiologica - Series Diagnosis",

issn = "0365-5954",

publisher = "SAGE Publications",

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TY - JOUR

T1 - High versus standard magnetic resonance image resolution of the cervical spine in patients with axial spondyloarthritis

AU - Krabbe, Simon

AU - Østergaard, Mikkel

AU - Sørensen, Inge J.

AU - Møller, Jakob

AU - Jensen, Bente

AU - Madsen, Ole R.

AU - Pedersen, Susanne J.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Background: Sagittal magnetic resonance (MR) images are typically obtained with the same spatial resolution along the entire spine, but cervical vertebrae are smaller and may be harder to assess. Purpose: To investigate if high-resolution (high-res) short tau inversion recovery (STIR) and T1-weighted turbo spin echo (T1W) MR imaging (MRI) sequences are superior to standard resolution for detecting inflammatory and structural lesions in the cervical spine of patients with axial spondyloarthritis. Material and Methods: Images were obtained in 36 patients. Voxel sizes at high/standard resolution were 1.99/4.33 mm3 (STIR) and 0.89/3.71 mm3 (T1W). High-resolution and standard-resolution images were scored by two readers according to the Canada-Denmark (CANDEN) MRI spine scoring system. Results: Higher bone marrow edema scores were obtained at high resolution versus standard resolution (mean 2.1 vs. 1.2, P = 0.040), whereas fat lesion scores (1.8 vs. 1.5, P = 0.27) and new bone formation scores (3.5 vs. 2.8, P = 0.21) were similar. High-resolution MRI did not classify more patients as positive for bone marrow edema, fat, or new bone formation in the cervical spine compared to standard resolution. Using lateral radiographs as reference standard, sensitivity for detecting anterior corner syndesmophytes with both high-resolution and standard-resolution MRI was low (range 7–22%) and sensitivity for detecting ankylosis was low to moderate (20–55%), while specificity was high (≥96%). Conclusion: High-resolution MRI allowed identification of more inflammatory lesions in the cervical spine in patients with axial spondyloarthritis when compared to standard resolution, but it did not classify more patients as positive for bone marrow edema. The slightly increased sensitivity at high-resolution MRI seemed to be too modest to have any real clinical importance.

AB - Background: Sagittal magnetic resonance (MR) images are typically obtained with the same spatial resolution along the entire spine, but cervical vertebrae are smaller and may be harder to assess. Purpose: To investigate if high-resolution (high-res) short tau inversion recovery (STIR) and T1-weighted turbo spin echo (T1W) MR imaging (MRI) sequences are superior to standard resolution for detecting inflammatory and structural lesions in the cervical spine of patients with axial spondyloarthritis. Material and Methods: Images were obtained in 36 patients. Voxel sizes at high/standard resolution were 1.99/4.33 mm3 (STIR) and 0.89/3.71 mm3 (T1W). High-resolution and standard-resolution images were scored by two readers according to the Canada-Denmark (CANDEN) MRI spine scoring system. Results: Higher bone marrow edema scores were obtained at high resolution versus standard resolution (mean 2.1 vs. 1.2, P = 0.040), whereas fat lesion scores (1.8 vs. 1.5, P = 0.27) and new bone formation scores (3.5 vs. 2.8, P = 0.21) were similar. High-resolution MRI did not classify more patients as positive for bone marrow edema, fat, or new bone formation in the cervical spine compared to standard resolution. Using lateral radiographs as reference standard, sensitivity for detecting anterior corner syndesmophytes with both high-resolution and standard-resolution MRI was low (range 7–22%) and sensitivity for detecting ankylosis was low to moderate (20–55%), while specificity was high (≥96%). Conclusion: High-resolution MRI allowed identification of more inflammatory lesions in the cervical spine in patients with axial spondyloarthritis when compared to standard resolution, but it did not classify more patients as positive for bone marrow edema. The slightly increased sensitivity at high-resolution MRI seemed to be too modest to have any real clinical importance.

KW - cervical vertebrae

KW - inflammation

KW - Magnetic resonance imaging

KW - spine

KW - spondyloarthropathies

U2 - 10.1177/0284185119872689

DO - 10.1177/0284185119872689

M3 - Journal article

C2 - 31480852

AN - SCOPUS:85073789123

SN - 0365-5954

JO - Acta Radiologica - Series Diagnosis

JF - Acta Radiologica - Series Diagnosis

ER -

High versus standard magnetic resonance image resolution of the cervical spine in patients with axial spondyloarthritis

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Keywords

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