High-throughput liquid-liquid extraction in 96-well format: Parallel artificial liquid membrane extraction

TY - JOUR

T1 - High-throughput liquid-liquid extraction in 96-well format: Parallel artificial liquid membrane extraction

AU - Gjelstad, Astrid

AU - Andresen, Alf Terje

AU - Dahlgren, Anders

AU - Gundersen, Thomas E

AU - Pedersen-Bjergaard, Stig

N1 - Også publiceret LC-GC North America Vol. 35 issue 3 – pp 192-196

PY - 2017

Y1 - 2017

N2 - Parallel artificial liquid membrane extraction (PALME) is a miniaturized version of liquid–liquid extraction (LLE) and is based on two 96-well plates in a sandwich-like configuration. With a very simple workflow, 96 samples can be processed simultaneously in PALME, providing analyte enrichment, highly efficient sample cleanup, and direct compatibility with liquid chromatography–mass spectrometry (LC–MS). The consumption of hazardous organic solvents is also almost eliminated using PALME as the sample preparation technique. This article summarizes current experiences with PALME, based on work both in a university laboratory and in an analytical services contract laboratory.

AB - Parallel artificial liquid membrane extraction (PALME) is a miniaturized version of liquid–liquid extraction (LLE) and is based on two 96-well plates in a sandwich-like configuration. With a very simple workflow, 96 samples can be processed simultaneously in PALME, providing analyte enrichment, highly efficient sample cleanup, and direct compatibility with liquid chromatography–mass spectrometry (LC–MS). The consumption of hazardous organic solvents is also almost eliminated using PALME as the sample preparation technique. This article summarizes current experiences with PALME, based on work both in a university laboratory and in an analytical services contract laboratory.

M3 - Journal article

SN - 1471-6577

VL - 30

SP - 10

EP - 17

JO - LCGC Europe

JF - LCGC Europe

IS - 1

ER -