High Serum Thyrotropin Levels are Associated with Current but not with Incident Hypertension

Till Ittermann; Daniel Tiller; Christa Meisinger; Carsten Agger; Matthias Nauck; Rainer Rettig; Albert Hofman; Oscar Franco; Torben Jørgensen; Allan Linneberg; Jacqueline Witteman; Halina Greiser; Karl Werdan; Angela Döring; Alexander Kluttig; Bruno Stricker; Henry Völzke

doi:10.1089/thy.2012.0626

High Serum Thyrotropin Levels are Associated with Current but not with Incident Hypertension

Till Ittermann, Daniel Tiller, Christa Meisinger, Carsten Agger, Matthias Nauck, Rainer Rettig, Albert Hofman, Oscar Franco, Torben Jørgensen, Allan Linneberg, Jacqueline Witteman, Halina Greiser, Karl Werdan, Angela Döring, Alexander Kluttig, Bruno Stricker, Henry Völzke

26 Citations (Scopus)

Abstract

Background: Recent data from a population-based study in children and adolescents suggest that serum thyrotropin (TSH) levels are associated with arterial blood pressure and hypertension. These results are in agreement with some but not all population-based studies in adults. Discrepancies in results might be explained by drug intake, different iodine supplies, and sizes of populations investigated. In addition, it is not clear whether an association between TSH and hypertension exists longitudinally or only cross-sectionally. Thus, our aim was to investigate cross-sectional and longitudinal associations between thyroid function and arterial blood pressure in a large consortium of cohort studies in adults. Methods: Data from five population-based studies were pooled resulting in 17,023 individuals being available for cross-sectional and 10,048 individuals for longitudinal analyses. Associations of baseline TSH with baseline blood pressure or hypertension were analyzed by multivariable median or logistic regression models. Multivariable median or Poisson regression models were used to investigate associations of baseline TSH with five-year change in arterial blood pressure or incident hypertension. Results: There was a cross-sectional positive association of TSH with arterial blood pressure (p<0.001) and hypertension (odds ratio [OR]=1.76 [confidence interval (CI) 1.24-2.50], p=0.002). Likewise, hypothyroidism was associated with systolic (β=1.1 [CI 0.1-2.1], p=0.040) and diastolic blood pressure (β=1.4 [CI 0.7-2.0], p<0.001). TSH, however, was not consistently associated with a five-year change in blood pressure or incident hypertension. Conclusions: High serum TSH levels were associated with current hypertension and blood pressure but not with a five-year change in blood pressure and incident hypertension. This argues for only a short-term effect of thyroid hormone levels on arterial blood pressure or a spurious association that needs further evaluation in population-based studies.

Original language	English
Journal	Thyroid
Volume	23
Issue number	8
Pages (from-to)	955-963
ISSN	1050-7256
DOIs	https://doi.org/10.1089/thy.2012.0626
Publication status	Published - 1 Aug 2013

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10.1089/thy.2012.0626

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Ittermann, T., Tiller, D., Meisinger, C., Agger, C., Nauck, M., Rettig, R., Hofman, A., Franco, O., Jørgensen, T., Linneberg, A., Witteman, J., Greiser, H., Werdan, K., Döring, A., Kluttig, A., Stricker, B., & Völzke, H. (2013). High Serum Thyrotropin Levels are Associated with Current but not with Incident Hypertension. Thyroid, 23(8), 955-963. https://doi.org/10.1089/thy.2012.0626

Ittermann, T, Tiller, D, Meisinger, C, Agger, C, Nauck, M, Rettig, R, Hofman, A, Franco, O, Jørgensen, T, Linneberg, A, Witteman, J, Greiser, H, Werdan, K, Döring, A, Kluttig, A, Stricker, B & Völzke, H 2013, 'High Serum Thyrotropin Levels are Associated with Current but not with Incident Hypertension', Thyroid, vol. 23, no. 8, pp. 955-963. https://doi.org/10.1089/thy.2012.0626

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title = "High Serum Thyrotropin Levels are Associated with Current but not with Incident Hypertension",

abstract = "Background: Recent data from a population-based study in children and adolescents suggest that serum thyrotropin (TSH) levels are associated with arterial blood pressure and hypertension. These results are in agreement with some but not all population-based studies in adults. Discrepancies in results might be explained by drug intake, different iodine supplies, and sizes of populations investigated. In addition, it is not clear whether an association between TSH and hypertension exists longitudinally or only cross-sectionally. Thus, our aim was to investigate cross-sectional and longitudinal associations between thyroid function and arterial blood pressure in a large consortium of cohort studies in adults. Methods: Data from five population-based studies were pooled resulting in 17,023 individuals being available for cross-sectional and 10,048 individuals for longitudinal analyses. Associations of baseline TSH with baseline blood pressure or hypertension were analyzed by multivariable median or logistic regression models. Multivariable median or Poisson regression models were used to investigate associations of baseline TSH with five-year change in arterial blood pressure or incident hypertension. Results: There was a cross-sectional positive association of TSH with arterial blood pressure (p<0.001) and hypertension (odds ratio [OR]=1.76 [confidence interval (CI) 1.24-2.50], p=0.002). Likewise, hypothyroidism was associated with systolic (β=1.1 [CI 0.1-2.1], p=0.040) and diastolic blood pressure (β=1.4 [CI 0.7-2.0], p<0.001). TSH, however, was not consistently associated with a five-year change in blood pressure or incident hypertension. Conclusions: High serum TSH levels were associated with current hypertension and blood pressure but not with a five-year change in blood pressure and incident hypertension. This argues for only a short-term effect of thyroid hormone levels on arterial blood pressure or a spurious association that needs further evaluation in population-based studies.",

author = "Till Ittermann and Daniel Tiller and Christa Meisinger and Carsten Agger and Matthias Nauck and Rainer Rettig and Albert Hofman and Oscar Franco and Torben J{\o}rgensen and Allan Linneberg and Jacqueline Witteman and Halina Greiser and Karl Werdan and Angela D{\"o}ring and Alexander Kluttig and Bruno Stricker and Henry V{\"o}lzke",

year = "2013",

month = aug,

day = "1",

doi = "10.1089/thy.2012.0626",

language = "English",

volume = "23",

pages = "955--963",

journal = "Thyroid",

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TY - JOUR

T1 - High Serum Thyrotropin Levels are Associated with Current but not with Incident Hypertension

AU - Ittermann, Till

AU - Tiller, Daniel

AU - Meisinger, Christa

AU - Agger, Carsten

AU - Nauck, Matthias

AU - Rettig, Rainer

AU - Hofman, Albert

AU - Franco, Oscar

AU - Jørgensen, Torben

AU - Linneberg, Allan

AU - Witteman, Jacqueline

AU - Greiser, Halina

AU - Werdan, Karl

AU - Döring, Angela

AU - Kluttig, Alexander

AU - Stricker, Bruno

AU - Völzke, Henry

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Background: Recent data from a population-based study in children and adolescents suggest that serum thyrotropin (TSH) levels are associated with arterial blood pressure and hypertension. These results are in agreement with some but not all population-based studies in adults. Discrepancies in results might be explained by drug intake, different iodine supplies, and sizes of populations investigated. In addition, it is not clear whether an association between TSH and hypertension exists longitudinally or only cross-sectionally. Thus, our aim was to investigate cross-sectional and longitudinal associations between thyroid function and arterial blood pressure in a large consortium of cohort studies in adults. Methods: Data from five population-based studies were pooled resulting in 17,023 individuals being available for cross-sectional and 10,048 individuals for longitudinal analyses. Associations of baseline TSH with baseline blood pressure or hypertension were analyzed by multivariable median or logistic regression models. Multivariable median or Poisson regression models were used to investigate associations of baseline TSH with five-year change in arterial blood pressure or incident hypertension. Results: There was a cross-sectional positive association of TSH with arterial blood pressure (p<0.001) and hypertension (odds ratio [OR]=1.76 [confidence interval (CI) 1.24-2.50], p=0.002). Likewise, hypothyroidism was associated with systolic (β=1.1 [CI 0.1-2.1], p=0.040) and diastolic blood pressure (β=1.4 [CI 0.7-2.0], p<0.001). TSH, however, was not consistently associated with a five-year change in blood pressure or incident hypertension. Conclusions: High serum TSH levels were associated with current hypertension and blood pressure but not with a five-year change in blood pressure and incident hypertension. This argues for only a short-term effect of thyroid hormone levels on arterial blood pressure or a spurious association that needs further evaluation in population-based studies.

AB - Background: Recent data from a population-based study in children and adolescents suggest that serum thyrotropin (TSH) levels are associated with arterial blood pressure and hypertension. These results are in agreement with some but not all population-based studies in adults. Discrepancies in results might be explained by drug intake, different iodine supplies, and sizes of populations investigated. In addition, it is not clear whether an association between TSH and hypertension exists longitudinally or only cross-sectionally. Thus, our aim was to investigate cross-sectional and longitudinal associations between thyroid function and arterial blood pressure in a large consortium of cohort studies in adults. Methods: Data from five population-based studies were pooled resulting in 17,023 individuals being available for cross-sectional and 10,048 individuals for longitudinal analyses. Associations of baseline TSH with baseline blood pressure or hypertension were analyzed by multivariable median or logistic regression models. Multivariable median or Poisson regression models were used to investigate associations of baseline TSH with five-year change in arterial blood pressure or incident hypertension. Results: There was a cross-sectional positive association of TSH with arterial blood pressure (p<0.001) and hypertension (odds ratio [OR]=1.76 [confidence interval (CI) 1.24-2.50], p=0.002). Likewise, hypothyroidism was associated with systolic (β=1.1 [CI 0.1-2.1], p=0.040) and diastolic blood pressure (β=1.4 [CI 0.7-2.0], p<0.001). TSH, however, was not consistently associated with a five-year change in blood pressure or incident hypertension. Conclusions: High serum TSH levels were associated with current hypertension and blood pressure but not with a five-year change in blood pressure and incident hypertension. This argues for only a short-term effect of thyroid hormone levels on arterial blood pressure or a spurious association that needs further evaluation in population-based studies.

U2 - 10.1089/thy.2012.0626

DO - 10.1089/thy.2012.0626

M3 - Journal article

C2 - 23427935

SN - 1050-7256

VL - 23

SP - 955

EP - 963

JO - Thyroid

JF - Thyroid

IS - 8

ER -

High Serum Thyrotropin Levels are Associated with Current but not with Incident Hypertension

Abstract

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