High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

Liselotte W Wijsman; Anton JM de Craen; Stella Trompet; Behnam Sabayan; Majon Muller; David J Stott; Ian Ford; Paul Welsh; Rudi GJ Westendorp; J Wouter Jukema; Naveed Sattar; Simon P Mooijaart

doi:10.1177/2047487316632364

High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

Liselotte W Wijsman, Anton JM de Craen, Stella Trompet, Behnam Sabayan, Majon Muller, David J Stott, Ian Ford, Paul Welsh, Rudi GJ Westendorp, J Wouter Jukema, Naveed Sattar, Simon P Mooijaart

11 Citations (Scopus)

Abstract

Aims Cardiac troponin T (cTnT), measured with a high-sensitivity (hs) assay, is associated with cognitive decline, but the underlying mechanism is unknown. We investigated the association of hs-cTnT with cognitive function and decline, and studied whether this association was independent of cardiovascular diseases or risk factors, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results We studied 5407 participants (mean age 75.31 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), who all had cardiovascular diseases or risk factors thereof. Participants with pre-existent advanced clinical heart failure were excluded. Hs-cTnT and NT-proBNP obtained after 6 months of follow-up were related with cognitive function, tested repeatedly during a mean follow-up of 3.2 years. Participants with higher hs-cTnT performed worse at baseline on Stroop test (mean baseline score (standard error (SE)) lowest vs highest third 65.91 (1.16) vs 69.40 (1.10) seconds, p < 0.001), Letter-Digit Coding test (23.35 (0.32) vs 22.40 (0.31) digits coded, p < 0.001), immediate Picture-Word Learning test (9.45 (0.09) vs 9.31 (0.08) pictures remembered, p = 0.002) and delayed Picture-Word Learning test (10.33 (0.12) vs 10.10 (0.12) pictures remembered, p = 0.013). Furthermore, participants with higher hs-cTnT had steeper decline on Stroop test (mean annual change (SE) lowest vs highest third 0.34 (0.12) vs 1.06 (0.12) seconds, p = 0.013), Letter-Digit Coding test (-0.29 (0.03) vs -0.46 (0.03) digits coded, p < 0.001), immediate Picture-Word Learning test (0.01 (0.01) vs -0.06 (0.01) pictures remembered, p < 0.001) and delayed Picture-Word Learning test (-0.03 (0.01) vs -0.12 (0.02) pictures remembered, p = 0.001). Associations were independent of cardiovascular diseases risk factors or Apolipoprotein E genotype. Further adjusting for NT-proBNP levels revealed the same results. Conclusions Higher levels of hs-cTnT associate with worse cognitive function and steeper cognitive decline in older adults independent of cardiovascular diseases, risk factors and NT-proBNP.

Original language	English
Journal	European Journal of Preventive Cardiology
Volume	23
Issue number	13
Pages (from-to)	1383-1392
Number of pages	10
ISSN	2047-4873
DOIs	https://doi.org/10.1177/2047487316632364
Publication status	Published - 1 Sept 2016

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Wijsman, L. W., de Craen, A. JM., Trompet, S., Sabayan, B., Muller, M., Stott, D. J., Ford, I., Welsh, P., Westendorp, R. GJ., Jukema, J. W., Sattar, N., & Mooijaart, S. P. (2016). High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk. European Journal of Preventive Cardiology, 23(13), 1383-1392. https://doi.org/10.1177/2047487316632364

Wijsman, LW, de Craen, AJM, Trompet, S, Sabayan, B, Muller, M, Stott, DJ, Ford, I, Welsh, P, Westendorp, RGJ, Jukema, JW, Sattar, N & Mooijaart, SP 2016, 'High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk', European Journal of Preventive Cardiology, vol. 23, no. 13, pp. 1383-1392. https://doi.org/10.1177/2047487316632364

@article{724b329bcb944e33979ac80a6ecaeced,

title = "High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk",

abstract = "Aims Cardiac troponin T (cTnT), measured with a high-sensitivity (hs) assay, is associated with cognitive decline, but the underlying mechanism is unknown. We investigated the association of hs-cTnT with cognitive function and decline, and studied whether this association was independent of cardiovascular diseases or risk factors, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results We studied 5407 participants (mean age 75.31 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), who all had cardiovascular diseases or risk factors thereof. Participants with pre-existent advanced clinical heart failure were excluded. Hs-cTnT and NT-proBNP obtained after 6 months of follow-up were related with cognitive function, tested repeatedly during a mean follow-up of 3.2 years. Participants with higher hs-cTnT performed worse at baseline on Stroop test (mean baseline score (standard error (SE)) lowest vs highest third 65.91 (1.16) vs 69.40 (1.10) seconds, p < 0.001), Letter-Digit Coding test (23.35 (0.32) vs 22.40 (0.31) digits coded, p < 0.001), immediate Picture-Word Learning test (9.45 (0.09) vs 9.31 (0.08) pictures remembered, p = 0.002) and delayed Picture-Word Learning test (10.33 (0.12) vs 10.10 (0.12) pictures remembered, p = 0.013). Furthermore, participants with higher hs-cTnT had steeper decline on Stroop test (mean annual change (SE) lowest vs highest third 0.34 (0.12) vs 1.06 (0.12) seconds, p = 0.013), Letter-Digit Coding test (-0.29 (0.03) vs -0.46 (0.03) digits coded, p < 0.001), immediate Picture-Word Learning test (0.01 (0.01) vs -0.06 (0.01) pictures remembered, p < 0.001) and delayed Picture-Word Learning test (-0.03 (0.01) vs -0.12 (0.02) pictures remembered, p = 0.001). Associations were independent of cardiovascular diseases risk factors or Apolipoprotein E genotype. Further adjusting for NT-proBNP levels revealed the same results. Conclusions Higher levels of hs-cTnT associate with worse cognitive function and steeper cognitive decline in older adults independent of cardiovascular diseases, risk factors and NT-proBNP.",

author = "Wijsman, {Liselotte W} and {de Craen}, {Anton JM} and Stella Trompet and Behnam Sabayan and Majon Muller and Stott, {David J} and Ian Ford and Paul Welsh and Westendorp, {Rudi GJ} and Jukema, {J Wouter} and Naveed Sattar and Mooijaart, {Simon P}",

note = "{\textcopyright} The European Society of Cardiology 2016.",

year = "2016",

month = sep,

day = "1",

doi = "10.1177/2047487316632364",

language = "English",

volume = "23",

pages = "1383--1392",

journal = "European Journal of Preventive Cardiology",

issn = "2047-4873",

publisher = "SAGE Publications",

number = "13",

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TY - JOUR

T1 - High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

AU - Wijsman, Liselotte W

AU - de Craen, Anton JM

AU - Trompet, Stella

AU - Sabayan, Behnam

AU - Muller, Majon

AU - Stott, David J

AU - Ford, Ian

AU - Welsh, Paul

AU - Westendorp, Rudi GJ

AU - Jukema, J Wouter

AU - Sattar, Naveed

AU - Mooijaart, Simon P

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Aims Cardiac troponin T (cTnT), measured with a high-sensitivity (hs) assay, is associated with cognitive decline, but the underlying mechanism is unknown. We investigated the association of hs-cTnT with cognitive function and decline, and studied whether this association was independent of cardiovascular diseases or risk factors, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results We studied 5407 participants (mean age 75.31 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), who all had cardiovascular diseases or risk factors thereof. Participants with pre-existent advanced clinical heart failure were excluded. Hs-cTnT and NT-proBNP obtained after 6 months of follow-up were related with cognitive function, tested repeatedly during a mean follow-up of 3.2 years. Participants with higher hs-cTnT performed worse at baseline on Stroop test (mean baseline score (standard error (SE)) lowest vs highest third 65.91 (1.16) vs 69.40 (1.10) seconds, p < 0.001), Letter-Digit Coding test (23.35 (0.32) vs 22.40 (0.31) digits coded, p < 0.001), immediate Picture-Word Learning test (9.45 (0.09) vs 9.31 (0.08) pictures remembered, p = 0.002) and delayed Picture-Word Learning test (10.33 (0.12) vs 10.10 (0.12) pictures remembered, p = 0.013). Furthermore, participants with higher hs-cTnT had steeper decline on Stroop test (mean annual change (SE) lowest vs highest third 0.34 (0.12) vs 1.06 (0.12) seconds, p = 0.013), Letter-Digit Coding test (-0.29 (0.03) vs -0.46 (0.03) digits coded, p < 0.001), immediate Picture-Word Learning test (0.01 (0.01) vs -0.06 (0.01) pictures remembered, p < 0.001) and delayed Picture-Word Learning test (-0.03 (0.01) vs -0.12 (0.02) pictures remembered, p = 0.001). Associations were independent of cardiovascular diseases risk factors or Apolipoprotein E genotype. Further adjusting for NT-proBNP levels revealed the same results. Conclusions Higher levels of hs-cTnT associate with worse cognitive function and steeper cognitive decline in older adults independent of cardiovascular diseases, risk factors and NT-proBNP.

AB - Aims Cardiac troponin T (cTnT), measured with a high-sensitivity (hs) assay, is associated with cognitive decline, but the underlying mechanism is unknown. We investigated the association of hs-cTnT with cognitive function and decline, and studied whether this association was independent of cardiovascular diseases or risk factors, and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods and results We studied 5407 participants (mean age 75.31 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), who all had cardiovascular diseases or risk factors thereof. Participants with pre-existent advanced clinical heart failure were excluded. Hs-cTnT and NT-proBNP obtained after 6 months of follow-up were related with cognitive function, tested repeatedly during a mean follow-up of 3.2 years. Participants with higher hs-cTnT performed worse at baseline on Stroop test (mean baseline score (standard error (SE)) lowest vs highest third 65.91 (1.16) vs 69.40 (1.10) seconds, p < 0.001), Letter-Digit Coding test (23.35 (0.32) vs 22.40 (0.31) digits coded, p < 0.001), immediate Picture-Word Learning test (9.45 (0.09) vs 9.31 (0.08) pictures remembered, p = 0.002) and delayed Picture-Word Learning test (10.33 (0.12) vs 10.10 (0.12) pictures remembered, p = 0.013). Furthermore, participants with higher hs-cTnT had steeper decline on Stroop test (mean annual change (SE) lowest vs highest third 0.34 (0.12) vs 1.06 (0.12) seconds, p = 0.013), Letter-Digit Coding test (-0.29 (0.03) vs -0.46 (0.03) digits coded, p < 0.001), immediate Picture-Word Learning test (0.01 (0.01) vs -0.06 (0.01) pictures remembered, p < 0.001) and delayed Picture-Word Learning test (-0.03 (0.01) vs -0.12 (0.02) pictures remembered, p = 0.001). Associations were independent of cardiovascular diseases risk factors or Apolipoprotein E genotype. Further adjusting for NT-proBNP levels revealed the same results. Conclusions Higher levels of hs-cTnT associate with worse cognitive function and steeper cognitive decline in older adults independent of cardiovascular diseases, risk factors and NT-proBNP.

U2 - 10.1177/2047487316632364

DO - 10.1177/2047487316632364

M3 - Journal article

C2 - 26884081

SN - 2047-4873

VL - 23

SP - 1383

EP - 1392

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

IS - 13

ER -

High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

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