Abstract
BACKGROUND/AIM: A possible predictive impact of ribonucleotide-reductase subunit-1 (RRM1) on vinorelbine efficacy in non-small cell lung cancer (NSCLC) has been previously reported. The present study aimed to further explore this finding in malignant pleural mesothelioma (MPM).
MATERIALS AND METHODS: Seventy-one patients with MPM receiving first-line chemotherapy with cisplatin-vinorelbine (CiV group, n=54) or carboplatin-pemetrexed (CaP group, n=17) were included. Formalin-fixed paraffin-embedded tumor specimens were analyzed by immunohistochemistry (IHC) for RRM1 expression using an H-score.
RESULTS: In 66 patients eligible for IHC, the H-score was ≥upper quartile in 21 (RRM1-positive) and <upper quartile (RRM1-negative) in 45 cases. The long-term (2-year) survival rate for patients with RRM1-negative MPM in the CiV-treated group was significantly superior to that for patients with RRM1-positive MPM (47% versus 13%, p=0.002). No difference occurred in the CaP-treated group.
CONCLUSION: Our findings suggest a possible role of RRM1 in predicting efficacy of cisplatin-vinorelbine in MPM, supporting previous findings in NSCLC.
| Original language | English |
|---|---|
| Journal | Anticancer Research |
| Volume | 35 |
| Issue number | 12 |
| Pages (from-to) | 6731-8 |
| Number of pages | 8 |
| ISSN | 0250-7005 |
| Publication status | Published - 1 Dec 2015 |
Keywords
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
- Biomarkers, Tumor
- Cisplatin
- Cohort Studies
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
- Male
- Mesothelioma
- Middle Aged
- Pleural Neoplasms
- Treatment Outcome
- Tumor Suppressor Proteins
- Vinblastine
