High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome

Lise Aksglaede; Jørgen H Petersen; Katharina M Main; Niels E Skakkebaek; Anders Juul

doi:http://dx.doi.org/10.1530/EJE-07-0310

High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome

Lise Aksglaede, Jørgen H Petersen, Katharina M Main, Niels E Skakkebaek, Anders Juul

66 Citations (Scopus)

Abstract

Klinefelter's syndrome (KS) is associated with hypergonadotrophic hypogonadism in adulthood. However, limited information exists about the age at which hypogonadism occurs. The hypothalamic-pituitary-gonadal (HPG) axis is transiently activated during the first months of life, offering the opportunity to study testicular function by spontaneous, basal hormone levels. The aim of this study was to evaluate the HPG axis in KS infants.

Original language	English
Journal	European Journal of Endocrinology
Volume	157
Issue number	3
Pages (from-to)	345-50
Number of pages	6
ISSN	0804-4643
DOIs	https://doi.org/10.1530/EJE-07-0310
Publication status	Published - 2007

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title = "High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome",

abstract = "Klinefelter's syndrome (KS) is associated with hypergonadotrophic hypogonadism in adulthood. However, limited information exists about the age at which hypogonadism occurs. The hypothalamic-pituitary-gonadal (HPG) axis is transiently activated during the first months of life, offering the opportunity to study testicular function by spontaneous, basal hormone levels. The aim of this study was to evaluate the HPG axis in KS infants.",

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AU - Aksglaede, Lise

AU - Petersen, Jørgen H

AU - Main, Katharina M

AU - Skakkebaek, Niels E

AU - Juul, Anders

PY - 2007

Y1 - 2007

N2 - Klinefelter's syndrome (KS) is associated with hypergonadotrophic hypogonadism in adulthood. However, limited information exists about the age at which hypogonadism occurs. The hypothalamic-pituitary-gonadal (HPG) axis is transiently activated during the first months of life, offering the opportunity to study testicular function by spontaneous, basal hormone levels. The aim of this study was to evaluate the HPG axis in KS infants.

AB - Klinefelter's syndrome (KS) is associated with hypergonadotrophic hypogonadism in adulthood. However, limited information exists about the age at which hypogonadism occurs. The hypothalamic-pituitary-gonadal (HPG) axis is transiently activated during the first months of life, offering the opportunity to study testicular function by spontaneous, basal hormone levels. The aim of this study was to evaluate the HPG axis in KS infants.

U2 - http://dx.doi.org/10.1530/EJE-07-0310

DO - http://dx.doi.org/10.1530/EJE-07-0310

M3 - Journal article

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VL - 157

SP - 345

EP - 350

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 3

ER -

High normal testosterone levels in infants with non-mosaic Klinefelter's syndrome

Abstract

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