High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes

Jannet Svensson; Stefanie Eising; Henrik Bindesbøl Mortensen; Michael Christiansen; Inga Laursen; Åke Lernmark; Anita Nilsson; Lars Bjarke Simonsen; Bendix Carstensen; Flemming Michael Pociot; Jesper Johannesen; Danish Childhood Diabetes Registry; Flemming Pociot

doi:10.1016/j.humimm.2011.10.019

High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes

Jannet Svensson, Stefanie Eising, Henrik Bindesbøl Mortensen, Michael Christiansen, Inga Laursen, Åke Lernmark, Anita Nilsson, Lars Bjarke Simonsen, Bendix Carstensen, Flemming Michael Pociot, Jesper Johannesen, Danish Childhood Diabetes Registry, Flemming Pociot

8 Citations (Scopus)

Abstract

The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p <0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p > 0.5) levels were found. Age-specific levels were unchanged over a 9-year period. In patients and siblings IgG, IgA and IgE increased by age (p <0.001); which was in contrast to IgM (p > 0.05). The continued increase in IgG levels by age indicates that adult levels are reached later than in previously studied cohorts, thereby indicating a slower maturation of the immune system.

Original language	English
Journal	Human Immunology
Volume	73
Issue number	1
Pages (from-to)	17-25
Number of pages	9
ISSN	0198-8859
DOIs	https://doi.org/10.1016/j.humimm.2011.10.019
Publication status	Published - Jan 2012

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10.1016/j.humimm.2011.10.019

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Svensson, J., Eising, S., Mortensen, H. B., Christiansen, M., Laursen, I., Lernmark, Å., Nilsson, A., Simonsen, L. B., Carstensen, B., Pociot, F. M., Johannesen, J., Danish Childhood Diabetes Registry, & Pociot, F. (2012). High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes. Human Immunology, 73(1), 17-25. https://doi.org/10.1016/j.humimm.2011.10.019

High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes. / Svensson, Jannet; Eising, Stefanie; Mortensen, Henrik Bindesbøl et al.

In: Human Immunology, Vol. 73, No. 1, 01.2012, p. 17-25.

Research output: Contribution to journal › Journal article › Research › peer-review

Svensson, J, Eising, S, Mortensen, HB, Christiansen, M, Laursen, I, Lernmark, Å, Nilsson, A, Simonsen, LB, Carstensen, B, Pociot, FM, Johannesen, J, Danish Childhood Diabetes Registry & Pociot, F 2012, 'High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes', Human Immunology, vol. 73, no. 1, pp. 17-25. https://doi.org/10.1016/j.humimm.2011.10.019

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title = "High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes",

abstract = "The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p <0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p > 0.5) levels were found. Age-specific levels were unchanged over a 9-year period. In patients and siblings IgG, IgA and IgE increased by age (p <0.001); which was in contrast to IgM (p > 0.05). The continued increase in IgG levels by age indicates that adult levels are reached later than in previously studied cohorts, thereby indicating a slower maturation of the immune system.",

author = "Jannet Svensson and Stefanie Eising and Mortensen, {Henrik Bindesb{\o}l} and Michael Christiansen and Inga Laursen and {\AA}ke Lernmark and Anita Nilsson and Simonsen, {Lars Bjarke} and Bendix Carstensen and Pociot, {Flemming Michael} and Jesper Johannesen and Mortensen, {Henrik B.} and Flemming Pociot",

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T1 - High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes

AU - Svensson, Jannet

AU - Eising, Stefanie

AU - Mortensen, Henrik Bindesbøl

AU - Christiansen, Michael

AU - Laursen, Inga

AU - Lernmark, Åke

AU - Nilsson, Anita

AU - Simonsen, Lars Bjarke

AU - Carstensen, Bendix

AU - Pociot, Flemming Michael

AU - Johannesen, Jesper

AU - Danish Childhood Diabetes Registry

AU - Pociot, Flemming

PY - 2012/1

Y1 - 2012/1

N2 - The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p <0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p > 0.5) levels were found. Age-specific levels were unchanged over a 9-year period. In patients and siblings IgG, IgA and IgE increased by age (p <0.001); which was in contrast to IgM (p > 0.05). The continued increase in IgG levels by age indicates that adult levels are reached later than in previously studied cohorts, thereby indicating a slower maturation of the immune system.

AB - The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p <0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p > 0.5) levels were found. Age-specific levels were unchanged over a 9-year period. In patients and siblings IgG, IgA and IgE increased by age (p <0.001); which was in contrast to IgM (p > 0.05). The continued increase in IgG levels by age indicates that adult levels are reached later than in previously studied cohorts, thereby indicating a slower maturation of the immune system.

U2 - 10.1016/j.humimm.2011.10.019

DO - 10.1016/j.humimm.2011.10.019

M3 - Journal article

C2 - 22057035

SN - 0198-8859

VL - 73

SP - 17

EP - 25

JO - Human Immunology

JF - Human Immunology

IS - 1

ER -

High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes

Abstract

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