High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment

Veronica D Gonzalez; Karolin Falconer; Kim G Blom; Olle Reichard; Birgitte Mørn; Alex Lund Laursen; Nina Weis; Annette Alaeus; Johan K Sandberg

doi:10.1128/JVI.01211-09

High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment

Veronica D Gonzalez, Karolin Falconer, Kim G Blom, Olle Reichard, Birgitte Mørn, Alex Lund Laursen, Nina Weis, Annette Alaeus, Johan K Sandberg

Department of Clinical Medicine

103 Citations (Scopus)

Abstract

Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients.

Original language	English
Journal	Journal of Virology
Volume	83
Issue number	21
Pages (from-to)	11407-11
Number of pages	4
ISSN	0022-538X
DOIs	https://doi.org/10.1128/JVI.01211-09 https://doi.org/10.1128/JVI.01211-09
Publication status	Published - 2009

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Gonzalez, V. D., Falconer, K., Blom, K. G., Reichard, O., Mørn, B., Laursen, A. L., Weis, N., Alaeus, A., & Sandberg, J. K. (2009). High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. Journal of Virology, 83(21), 11407-11. https://doi.org/10.1128/JVI.01211-09, https://doi.org/10.1128/JVI.01211-09

High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. / Gonzalez, Veronica D; Falconer, Karolin; Blom, Kim G et al.

In: Journal of Virology, Vol. 83, No. 21, 2009, p. 11407-11.

Research output: Contribution to journal › Journal article › Research › peer-review

Gonzalez, VD, Falconer, K, Blom, KG, Reichard, O, Mørn, B, Laursen, AL, Weis, N, Alaeus, A & Sandberg, JK 2009, 'High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment', Journal of Virology, vol. 83, no. 21, pp. 11407-11. https://doi.org/10.1128/JVI.01211-09, https://doi.org/10.1128/JVI.01211-09

Gonzalez VD, Falconer K, Blom KG, Reichard O, Mørn B, Laursen AL et al. High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. Journal of Virology. 2009;83(21):11407-11. doi: 10.1128/JVI.01211-09, http://dx.doi.org/10.1128/JVI.01211-09

Gonzalez, Veronica D ; Falconer, Karolin ; Blom, Kim G et al. / High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment. In: Journal of Virology. 2009 ; Vol. 83, No. 21. pp. 11407-11.

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title = "High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment",

abstract = "Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients.",

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note = "Keywords: Adult; Antigens, CD38; Antiretroviral Therapy, Highly Active; Antiviral Agents; Disease Progression; Female; HIV Infections; HIV-1; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Lymphocyte Activation; Male; Middle Aged; Ribavirin; T-Lymphocyte Subsets; T-Lymphocytes; Viral Load; Young Adult",

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AU - Blom, Kim G

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AU - Mørn, Birgitte

AU - Laursen, Alex Lund

AU - Weis, Nina

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AU - Sandberg, Johan K

N1 - Keywords: Adult; Antigens, CD38; Antiretroviral Therapy, Highly Active; Antiviral Agents; Disease Progression; Female; HIV Infections; HIV-1; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Lymphocyte Activation; Male; Middle Aged; Ribavirin; T-Lymphocyte Subsets; T-Lymphocytes; Viral Load; Young Adult

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AB - Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients.

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