High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding

Vibe G Frokjaer; Maj Vinberg; David Erritzoe; Claus Svarer; William Baaré; Esben Budtz-Joergensen; Karine Madsen; Jacob Madsen; Lars V Kessing; Gitte M Knudsen; Vibe G Frokjaer; Maj Vinberg; David Erritzoe; Claus Svarer; William Baaré; Esben Budtz-Joergensen; Karine Madsen; Jacob Madsen; Lars V Kessing; Gitte Moos Knudsen

doi:10.1016/j.neuroimage.2009.02.008

High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding

Vibe G Frokjaer, Maj Vinberg, David Erritzoe, Claus Svarer, William Baaré, Esben Budtz-Joergensen, Karine Madsen, Jacob Madsen, Lars V Kessing, Gitte M Knudsen, Vibe G Frokjaer, Maj Vinberg, David Erritzoe, Claus Svarer, William Baaré, Esben Budtz-Joergensen, Karine Madsen, Jacob Madsen, Lars V Kessing, Gitte Moos Knudsen

46 Citations (Scopus)

Abstract

Mood disorders are elicited through a combination of genetic and environmental stress factors, and treatment with selective serotonin reuptake inhibitors ameliorates depressive symptoms. Changes in the serotonin transporter (SERT) binding may therefore occur in depressive patients and in subjects at risk for developing depression. The aim of this study was to explore whether abnormalities in SERT might be present in healthy individuals with familial predisposition to mood disorder. Nine individuals at high familial risk (mean age 32.2+/-4.2 years) and 11 individuals at low risk (mean age 32.4+/-5.0 years) for developing mood disorder were included. The subjects were healthy twins with or without a co-twin history of mood disorder identified by linking information from the Danish Twin Register and the Danish Psychiatric Central Register. Regional in vivo brain serotonin transporter binding was measured with [(11)C]DASB PET. The volumes of interest included the orbitofrontal cortex, the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex, anterior cingulate, caudate, putamen, thalamus, and midbrain. We found that individuals at high familial risk for mood disorders had a 35% reduction in SERT binding in dorsolateral prefrontal cortex (p=0.014, Bonferroni corrected) and on a trend basis a 15% reduction in anterior cingulate (p=0.018, un-corrected). The depression and symptom scores of the high and the low risk individuals were not significantly different. In conclusion, our data suggest that a low SERT binding in dorsolateral prefrontal cortex represents a trait marker for mood disorders.

Original language	English
Journal	NeuroImage
Volume	46
Issue number	2
Pages (from-to)	360-6
Number of pages	6
ISSN	1053-8119
DOIs	https://doi.org/10.1016/j.neuroimage.2009.02.008 https://doi.org/10.1016/j.neuroimage.2009.02.008
Publication status	Published - 2009

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Frokjaer, V. G., Vinberg, M., Erritzoe, D., Svarer, C., Baaré, W., Budtz-Joergensen, E., Madsen, K., Madsen, J., Kessing, L. V., Knudsen, G. M., Frokjaer, V. G., Vinberg, M., Erritzoe, D., Svarer, C., Baaré, W., Budtz-Joergensen, E., Madsen, K., Madsen, J., Kessing, L. V., & Knudsen, G. M. (2009). High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. NeuroImage, 46(2), 360-6. https://doi.org/10.1016/j.neuroimage.2009.02.008, https://doi.org/10.1016/j.neuroimage.2009.02.008

Frokjaer, VG, Vinberg, M, Erritzoe, D, Svarer, C, Baaré, W, Budtz-Joergensen, E, Madsen, K, Madsen, J, Kessing, LV , Knudsen, GM, Frokjaer, VG, Vinberg, M, Erritzoe, D, Svarer, C, Baaré, W, Budtz-Joergensen, E, Madsen, K, Madsen, J, Kessing, LV & Knudsen, GM 2009, 'High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding', NeuroImage, vol. 46, no. 2, pp. 360-6. https://doi.org/10.1016/j.neuroimage.2009.02.008, https://doi.org/10.1016/j.neuroimage.2009.02.008

@article{6f3ea020a92a11df928f000ea68e967b,

title = "High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding",

abstract = "Mood disorders are elicited through a combination of genetic and environmental stress factors, and treatment with selective serotonin reuptake inhibitors ameliorates depressive symptoms. Changes in the serotonin transporter (SERT) binding may therefore occur in depressive patients and in subjects at risk for developing depression. The aim of this study was to explore whether abnormalities in SERT might be present in healthy individuals with familial predisposition to mood disorder. Nine individuals at high familial risk (mean age 32.2+/-4.2 years) and 11 individuals at low risk (mean age 32.4+/-5.0 years) for developing mood disorder were included. The subjects were healthy twins with or without a co-twin history of mood disorder identified by linking information from the Danish Twin Register and the Danish Psychiatric Central Register. Regional in vivo brain serotonin transporter binding was measured with [(11)C]DASB PET. The volumes of interest included the orbitofrontal cortex, the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex, anterior cingulate, caudate, putamen, thalamus, and midbrain. We found that individuals at high familial risk for mood disorders had a 35% reduction in SERT binding in dorsolateral prefrontal cortex (p=0.014, Bonferroni corrected) and on a trend basis a 15% reduction in anterior cingulate (p=0.018, un-corrected). The depression and symptom scores of the high and the low risk individuals were not significantly different. In conclusion, our data suggest that a low SERT binding in dorsolateral prefrontal cortex represents a trait marker for mood disorders.",

author = "Frokjaer, {Vibe G} and Maj Vinberg and David Erritzoe and Claus Svarer and William Baar{\'e} and Esben Budtz-Joergensen and Karine Madsen and Jacob Madsen and Kessing, {Lars V} and Knudsen, {Gitte M} and Frokjaer, {Vibe G} and Maj Vinberg and David Erritzoe and Claus Svarer and William Baar{\'e} and Esben Budtz-Joergensen and Karine Madsen and Jacob Madsen and Kessing, {Lars V} and Knudsen, {Gitte Moos}",

note = "Keywords: Adult; Aniline Compounds; Diseases in Twins; Family; Female; Humans; Male; Mood Disorders; Positron-Emission Tomography; Prefrontal Cortex; Protein Binding; Radiopharmaceuticals; Risk Factors; Serotonin Plasma Membrane Transport Proteins; Sulfides; Tissue Distribution",

year = "2009",

doi = "10.1016/j.neuroimage.2009.02.008",

language = "English",

volume = "46",

pages = "360--6",

journal = "NeuroImage",

issn = "1053-8119",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding

AU - Frokjaer, Vibe G

AU - Vinberg, Maj

AU - Erritzoe, David

AU - Svarer, Claus

AU - Baaré, William

AU - Budtz-Joergensen, Esben

AU - Madsen, Karine

AU - Madsen, Jacob

AU - Kessing, Lars V

AU - Knudsen, Gitte M

AU - Frokjaer, Vibe G

AU - Vinberg, Maj

AU - Erritzoe, David

AU - Svarer, Claus

AU - Baaré, William

AU - Budtz-Joergensen, Esben

AU - Madsen, Karine

AU - Madsen, Jacob

AU - Kessing, Lars V

AU - Knudsen, Gitte Moos

N1 - Keywords: Adult; Aniline Compounds; Diseases in Twins; Family; Female; Humans; Male; Mood Disorders; Positron-Emission Tomography; Prefrontal Cortex; Protein Binding; Radiopharmaceuticals; Risk Factors; Serotonin Plasma Membrane Transport Proteins; Sulfides; Tissue Distribution

PY - 2009

Y1 - 2009

N2 - Mood disorders are elicited through a combination of genetic and environmental stress factors, and treatment with selective serotonin reuptake inhibitors ameliorates depressive symptoms. Changes in the serotonin transporter (SERT) binding may therefore occur in depressive patients and in subjects at risk for developing depression. The aim of this study was to explore whether abnormalities in SERT might be present in healthy individuals with familial predisposition to mood disorder. Nine individuals at high familial risk (mean age 32.2+/-4.2 years) and 11 individuals at low risk (mean age 32.4+/-5.0 years) for developing mood disorder were included. The subjects were healthy twins with or without a co-twin history of mood disorder identified by linking information from the Danish Twin Register and the Danish Psychiatric Central Register. Regional in vivo brain serotonin transporter binding was measured with [(11)C]DASB PET. The volumes of interest included the orbitofrontal cortex, the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex, anterior cingulate, caudate, putamen, thalamus, and midbrain. We found that individuals at high familial risk for mood disorders had a 35% reduction in SERT binding in dorsolateral prefrontal cortex (p=0.014, Bonferroni corrected) and on a trend basis a 15% reduction in anterior cingulate (p=0.018, un-corrected). The depression and symptom scores of the high and the low risk individuals were not significantly different. In conclusion, our data suggest that a low SERT binding in dorsolateral prefrontal cortex represents a trait marker for mood disorders.

AB - Mood disorders are elicited through a combination of genetic and environmental stress factors, and treatment with selective serotonin reuptake inhibitors ameliorates depressive symptoms. Changes in the serotonin transporter (SERT) binding may therefore occur in depressive patients and in subjects at risk for developing depression. The aim of this study was to explore whether abnormalities in SERT might be present in healthy individuals with familial predisposition to mood disorder. Nine individuals at high familial risk (mean age 32.2+/-4.2 years) and 11 individuals at low risk (mean age 32.4+/-5.0 years) for developing mood disorder were included. The subjects were healthy twins with or without a co-twin history of mood disorder identified by linking information from the Danish Twin Register and the Danish Psychiatric Central Register. Regional in vivo brain serotonin transporter binding was measured with [(11)C]DASB PET. The volumes of interest included the orbitofrontal cortex, the dorsolateral prefrontal cortex, the ventrolateral prefrontal cortex, anterior cingulate, caudate, putamen, thalamus, and midbrain. We found that individuals at high familial risk for mood disorders had a 35% reduction in SERT binding in dorsolateral prefrontal cortex (p=0.014, Bonferroni corrected) and on a trend basis a 15% reduction in anterior cingulate (p=0.018, un-corrected). The depression and symptom scores of the high and the low risk individuals were not significantly different. In conclusion, our data suggest that a low SERT binding in dorsolateral prefrontal cortex represents a trait marker for mood disorders.

U2 - 10.1016/j.neuroimage.2009.02.008

DO - 10.1016/j.neuroimage.2009.02.008

M3 - Journal article

C2 - 19233297

SN - 1053-8119

VL - 46

SP - 360

EP - 366

JO - NeuroImage

JF - NeuroImage

IS - 2

ER -

High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding

Abstract

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