High cortisol awakening response is associated with an impairment of the effect of bright light therapy

Klaus Per Juul Martiny; Marianne Anita Lunde; M Undén; Ole Henrik Dam; P Bech

doi:http://dx.doi.org/10.1111/j.1600-0447.2009.01359.x

High cortisol awakening response is associated with an impairment of the effect of bright light therapy

Klaus Per Juul Martiny, Marianne Anita Lunde, M Undén, Ole Henrik Dam, P Bech

10 Citations (Scopus)

Abstract

OBJECTIVE: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. METHOD: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. RESULTS: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. CONCLUSION: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.

Original language	English
Journal	Acta Psychiatrica Scandinavica
Volume	120
Issue number	3
Pages (from-to)	196-202
Number of pages	7
ISSN	0001-690X
DOIs	https://doi.org/10.1111/j.1600-0447.2009.01359.x
Publication status	Published - 1 Sept 2009

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title = "High cortisol awakening response is associated with an impairment of the effect of bright light therapy",

abstract = "OBJECTIVE: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. METHOD: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. RESULTS: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. CONCLUSION: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.",

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T1 - High cortisol awakening response is associated with an impairment of the effect of bright light therapy

AU - Martiny, Klaus Per Juul

AU - Lunde, Marianne Anita

AU - Undén, M

AU - Dam, Ole Henrik

AU - Bech, P

PY - 2009/9/1

Y1 - 2009/9/1

N2 - OBJECTIVE: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. METHOD: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. RESULTS: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. CONCLUSION: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.

AB - OBJECTIVE: We investigated the predictive validity of the cortisol awakening response (CAR) in patients with non-seasonal major depression. METHOD: Patients were treated with sertraline in combination with bright or dim light therapy for a 5-week period. Saliva cortisol levels were measured in 63 patients, as an awakening profile, before medication and light therapy started. The CAR was calculated by using three time-points: awakening and 20 and 60 min after awakening. RESULTS: Patients with low CAR had a very substantial effect of bright light therapy compared with dim light therapy, whereas patients with a high CAR had no effect of bright light therapy compared with dim light therapy. CONCLUSION: High CAR was associated with an impairment of the effect of bright light therapy. This result raises the question of whether bright light acts through a mechanism different from that of antidepressants.

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DO - http://dx.doi.org/10.1111/j.1600-0447.2009.01359.x

M3 - Journal article

SN - 0001-690X

VL - 120

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EP - 202

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

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ER -

High cortisol awakening response is associated with an impairment of the effect of bright light therapy

Abstract

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