Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

J Eugen-Olsen; Anton Iversen; P Garred; Uffe Koppelhus; C Pedersen; Thomas Benfield; A M Sorensen; T Katzenstein; E Dickmeiss; J Gerstoft; P Skinhøj; A Svejgaard; J O Nielsen; B Hofmann

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

J Eugen-Olsen, Anton Iversen, P Garred, Uffe Koppelhus, C Pedersen, Thomas Benfield, A M Sorensen, T Katzenstein, E Dickmeiss, J Gerstoft, P Skinhøj, A Svejgaard, J O Nielsen, B Hofmann

196 Citations (Scopus)

Abstract

Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.

Original language	English
Journal	AIDS
Volume	11
Issue number	3
Pages (from-to)	305-10
Number of pages	6
ISSN	0269-9370
Publication status	Published - 1997

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Eugen-Olsen, J., Iversen, A., Garred, P., Koppelhus, U., Pedersen, C., Benfield, T., Sorensen, A. M., Katzenstein, T., Dickmeiss, E., Gerstoft, J., Skinhøj, P., Svejgaard, A., Nielsen, J. O., & Hofmann, B. (1997). Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS, 11(3), 305-10.

Eugen-Olsen, J, Iversen, A, Garred, P, Koppelhus, U, Pedersen, C, Benfield, T, Sorensen, AM, Katzenstein, T, Dickmeiss, E, Gerstoft, J, Skinhøj, P, Svejgaard, A, Nielsen, JO & Hofmann, B 1997, 'Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals', AIDS, vol. 11, no. 3, pp. 305-10.

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abstract = "Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.",

author = "J Eugen-Olsen and Anton Iversen and P Garred and Uffe Koppelhus and C Pedersen and Thomas Benfield and Sorensen, {A M} and T Katzenstein and E Dickmeiss and J Gerstoft and P Skinh{\o}j and A Svejgaard and Nielsen, {J O} and B Hofmann",

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AU - Eugen-Olsen, J

AU - Iversen, Anton

AU - Garred, P

AU - Koppelhus, Uffe

AU - Pedersen, C

AU - Benfield, Thomas

AU - Sorensen, A M

AU - Katzenstein, T

AU - Dickmeiss, E

AU - Gerstoft, J

AU - Skinhøj, P

AU - Svejgaard, A

AU - Nielsen, J O

AU - Hofmann, B

PY - 1997

Y1 - 1997

N2 - Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.

AB - Recently, it has been shown that a homozygous 32 base-pair deletion in the gene encoding CKR-5, a major coreceptor for HIV-1, leads to resistance to infection with HIV-1. We have investigated whether HIV-seropositive individuals who were heterozygous for the CKR-5 deletion had a different course of the disease.

M3 - Journal article

SN - 1350-2840

VL - 11

SP - 305

EP - 310

JO - AIDS, Supplement

JF - AIDS, Supplement

IS - 3

ER -

Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals

Abstract

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