TY - JOUR
T1 - Heterogeneity and weak coupling may explain the synchronization characteristics of cells in the arterial wall.
AU - Jacobsen, Jens Christian Brings
AU - Aalkjær, Christian
AU - Matchkov, Vladimir V
AU - Nilsson, Holger
AU - Holstein-Rathlou, N.-H.
AU - Freiberg, Jacob J
N1 - Keywords: 5'-Guanylic Acid; Animals; Arteries; Calcium; Calcium Signaling; Cytosol; Gap Junctions; Membrane Potentials; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oscillometry; Rats; Rats, Wistar
PY - 2008
Y1 - 2008
N2 - Vascular smooth muscle cells (SMCs) exhibit different types of calcium dynamics. Static vascular tone is associated with unsynchronized calcium waves and the developed force depends on the number of recruited cells. Global calcium transients synchronized among a large number of cells cause rhythmic development of force known as vasomotion. We present experimental data showing a considerable heterogeneity in cellular calcium dynamics in the vascular wall. In stimulated vessels, some SMCs remain quiescent, whereas others display waves of variable frequency. At the onset of vasomotion, all SMCs are enrolled into synchronized oscillation.Simulations of coupled SMCs show that the experimentally observed cellular recruitment, the presence of quiescent cells and the variation in oscillation frequency may arise if the cell population is phenotypically heterogeneous. In this case, quiescent cells can be entrained at the onset of vasomotion by the collective driving force from the synchronized oscillations in the membrane potential of the surrounding cells. Partial synchronization arises with an increase in the concentration of cyclic guanosine monophosphate, but in a heterogeneous cell population complete synchronization also requires a high-conductance pathway that provides strong coupling between the cells.
AB - Vascular smooth muscle cells (SMCs) exhibit different types of calcium dynamics. Static vascular tone is associated with unsynchronized calcium waves and the developed force depends on the number of recruited cells. Global calcium transients synchronized among a large number of cells cause rhythmic development of force known as vasomotion. We present experimental data showing a considerable heterogeneity in cellular calcium dynamics in the vascular wall. In stimulated vessels, some SMCs remain quiescent, whereas others display waves of variable frequency. At the onset of vasomotion, all SMCs are enrolled into synchronized oscillation.Simulations of coupled SMCs show that the experimentally observed cellular recruitment, the presence of quiescent cells and the variation in oscillation frequency may arise if the cell population is phenotypically heterogeneous. In this case, quiescent cells can be entrained at the onset of vasomotion by the collective driving force from the synchronized oscillations in the membrane potential of the surrounding cells. Partial synchronization arises with an increase in the concentration of cyclic guanosine monophosphate, but in a heterogeneous cell population complete synchronization also requires a high-conductance pathway that provides strong coupling between the cells.
U2 - 10.1098/rsta.2008.0105
DO - 10.1098/rsta.2008.0105
M3 - Journal article
C2 - 18632459
SN - 1364-503X
VL - 366
SP - 3483
EP - 3502
JO - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
JF - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
IS - 1880
ER -