Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women

TY - JOUR

T1 - Herring and chicken/pork meals lead to differences in plasma levels of TCA intermediates and arginine metabolites in overweight and obese men and women

AU - Vincent, Andrew

AU - Savolainen, Otto I

AU - Sen, Partho

AU - Carlsson, Nils-Gunnar

AU - Almgren, Annette

AU - Lindqvist, Helen

AU - Lind, Mads Vendelbo

AU - Undeland, Ingrid

AU - Sandberg, Ann-Sofie

AU - Ross, Alastair B.

N1 - CURIS 2017 NEXS 029

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Scope: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome?Method and results: A randomised crossover trial with 15 healthy obese men and women (age 24–70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics.The herring diet decreased plasma citrate, fumarate, isocitrate, glycolate, oxalate, agmatine and methyhistidine and increased asparagine, ornithine, glutamine and the hexosamine glucosamine. Modelling found that the tricarboxylic acid cycle, glyoxylate, and argininemetabolism were affected by the intervention. The effect on arginine metabolism was supported by an increasein blood nitric oxide in males on the herring diet.Conclusion: The results suggest that eating herring instead of chicken and lean pork leads to important metabolic effects, particularly on energy and amino acid metabolism. Our findings support the hypothesis that there are metabolic effects of herring intake unrelated to the long chain n-3 polyunsaturated fatty acid content.

AB - Scope: What effect does replacing chicken or pork with herring as the main dietary source of protein have on the human plasma metabolome?Method and results: A randomised crossover trial with 15 healthy obese men and women (age 24–70 years). Subjects were randomly assigned to four weeks of herring diet or a reference diet of chicken and lean pork, five meals per week, followed by a washout and the other intervention arm. Fasting blood serum metabolites were analysed at 0, 2 and 4 weeks for eleven subjects with available samples, using GC-MS based metabolomics.The herring diet decreased plasma citrate, fumarate, isocitrate, glycolate, oxalate, agmatine and methyhistidine and increased asparagine, ornithine, glutamine and the hexosamine glucosamine. Modelling found that the tricarboxylic acid cycle, glyoxylate, and argininemetabolism were affected by the intervention. The effect on arginine metabolism was supported by an increasein blood nitric oxide in males on the herring diet.Conclusion: The results suggest that eating herring instead of chicken and lean pork leads to important metabolic effects, particularly on energy and amino acid metabolism. Our findings support the hypothesis that there are metabolic effects of herring intake unrelated to the long chain n-3 polyunsaturated fatty acid content.

KW - Faculty of Science

KW - Arginine

KW - Central energy metabolism

KW - Chicken

KW - Herring

KW - Pork

U2 - 10.1002/mnfr.201600400

DO - 10.1002/mnfr.201600400

M3 - Journal article

C2 - 27801550

SN - 1613-4125

VL - 61

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

IS - 3

M1 - 1600400

ER -