Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection

Shona Wilson; Francis M. Jones; Joseph K. Mwatha; Gachuhi Kimani; Mark Booth; H. Curtis Kariuki; Birgitte J Vennervald; John H. Ouma; Eric Muchiri; David W. Dunne

doi:10.1128/IAI.01433-07

Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection

Shona Wilson, Francis M. Jones, Joseph K. Mwatha, Gachuhi Kimani, Mark Booth, H. Curtis Kariuki, Birgitte J Vennervald, John H. Ouma, Eric Muchiri, David W. Dunne

30 Citations (Scopus)

Abstract

Hepatosplenomegaly among Kenyan schoolchildren has been shown to be exacerbated
where there is transmission of both Schistosoma mansoni and Plasmodium
falciparum. This highly prevalent and chronic morbidity often occurs in the
absence of ultrasound-detectable periportal fibrosis and may be due to
immunological inflammation. For a cohort of school-age children, whole-blood
cultures were stimulated with S. mansoni soluble egg antigen (SEA) or soluble
worm antigen (SWA). Responses to SWA were found to be predominantly Th2
cytokines; however, they were not significantly associated with either
hepatosplenomegaly or infection with S. mansoni or P. falciparum. In comparison,
SEA-specific Th2 cytokine responses were low, and the levels were negatively
correlated with S. mansoni infection intensities and were lower among children
who were coinfected with P. falciparum. Tumor necrosis factor alpha levels in
response to stimulation with SEA were high, and a negative association between
presentation with hepatomegaly and the levels of the regulatory cytokines
interleukin-6 and transforming growth factor beta(1) suggests that a possible
mechanism for childhood hepatomegaly in areas where both malaria and
schistosomiasis are endemic is poor regulation of an inflammatory response to
schistosome eggs.

Original language	English
Journal	Infection and Immunity
Volume	76
Issue number	5
Pages (from-to)	2212-2218
Number of pages	7
ISSN	0019-9567
DOIs	https://doi.org/10.1128/IAI.01433-07
Publication status	Published - 2008

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10.1128/IAI.01433-07

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Wilson, S., Jones, F. M., Mwatha, J. K., Kimani, G., Booth, M., Kariuki, H. C., Vennervald, B. J., Ouma, J. H., Muchiri, E., & Dunne, D. W. (2008). Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection. Infection and Immunity, 76(5), 2212-2218. https://doi.org/10.1128/IAI.01433-07

@article{59e8caf0d8bd11dd9473000ea68e967b,

title = "Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection",

abstract = "Hepatosplenomegaly among Kenyan schoolchildren has been shown to be exacerbatedwhere there is transmission of both Schistosoma mansoni and Plasmodiumfalciparum. This highly prevalent and chronic morbidity often occurs in theabsence of ultrasound-detectable periportal fibrosis and may be due toimmunological inflammation. For a cohort of school-age children, whole-bloodcultures were stimulated with S. mansoni soluble egg antigen (SEA) or solubleworm antigen (SWA). Responses to SWA were found to be predominantly Th2cytokines; however, they were not significantly associated with eitherhepatosplenomegaly or infection with S. mansoni or P. falciparum. In comparison, SEA-specific Th2 cytokine responses were low, and the levels were negativelycorrelated with S. mansoni infection intensities and were lower among childrenwho were coinfected with P. falciparum. Tumor necrosis factor alpha levels inresponse to stimulation with SEA were high, and a negative association betweenpresentation with hepatomegaly and the levels of the regulatory cytokinesinterleukin-6 and transforming growth factor beta(1) suggests that a possiblemechanism for childhood hepatomegaly in areas where both malaria andschistosomiasis are endemic is poor regulation of an inflammatory response toschistosome eggs.",

author = "Shona Wilson and Jones, {Francis M.} and Mwatha, {Joseph K.} and Gachuhi Kimani and Mark Booth and Kariuki, {H. Curtis} and Vennervald, {Birgitte J} and Ouma, {John H.} and Eric Muchiri and Dunne, {David W.}",

year = "2008",

doi = "10.1128/IAI.01433-07",

language = "English",

volume = "76",

pages = "2212--2218",

journal = "Infection and Immunity",

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TY - JOUR

T1 - Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection

AU - Wilson, Shona

AU - Jones, Francis M.

AU - Mwatha, Joseph K.

AU - Kimani, Gachuhi

AU - Booth, Mark

AU - Kariuki, H. Curtis

AU - Vennervald, Birgitte J

AU - Ouma, John H.

AU - Muchiri, Eric

AU - Dunne, David W.

PY - 2008

Y1 - 2008

N2 - Hepatosplenomegaly among Kenyan schoolchildren has been shown to be exacerbatedwhere there is transmission of both Schistosoma mansoni and Plasmodiumfalciparum. This highly prevalent and chronic morbidity often occurs in theabsence of ultrasound-detectable periportal fibrosis and may be due toimmunological inflammation. For a cohort of school-age children, whole-bloodcultures were stimulated with S. mansoni soluble egg antigen (SEA) or solubleworm antigen (SWA). Responses to SWA were found to be predominantly Th2cytokines; however, they were not significantly associated with eitherhepatosplenomegaly or infection with S. mansoni or P. falciparum. In comparison, SEA-specific Th2 cytokine responses were low, and the levels were negativelycorrelated with S. mansoni infection intensities and were lower among childrenwho were coinfected with P. falciparum. Tumor necrosis factor alpha levels inresponse to stimulation with SEA were high, and a negative association betweenpresentation with hepatomegaly and the levels of the regulatory cytokinesinterleukin-6 and transforming growth factor beta(1) suggests that a possiblemechanism for childhood hepatomegaly in areas where both malaria andschistosomiasis are endemic is poor regulation of an inflammatory response toschistosome eggs.

AB - Hepatosplenomegaly among Kenyan schoolchildren has been shown to be exacerbatedwhere there is transmission of both Schistosoma mansoni and Plasmodiumfalciparum. This highly prevalent and chronic morbidity often occurs in theabsence of ultrasound-detectable periportal fibrosis and may be due toimmunological inflammation. For a cohort of school-age children, whole-bloodcultures were stimulated with S. mansoni soluble egg antigen (SEA) or solubleworm antigen (SWA). Responses to SWA were found to be predominantly Th2cytokines; however, they were not significantly associated with eitherhepatosplenomegaly or infection with S. mansoni or P. falciparum. In comparison, SEA-specific Th2 cytokine responses were low, and the levels were negativelycorrelated with S. mansoni infection intensities and were lower among childrenwho were coinfected with P. falciparum. Tumor necrosis factor alpha levels inresponse to stimulation with SEA were high, and a negative association betweenpresentation with hepatomegaly and the levels of the regulatory cytokinesinterleukin-6 and transforming growth factor beta(1) suggests that a possiblemechanism for childhood hepatomegaly in areas where both malaria andschistosomiasis are endemic is poor regulation of an inflammatory response toschistosome eggs.

U2 - 10.1128/IAI.01433-07

DO - 10.1128/IAI.01433-07

M3 - Journal article

C2 - 18285496

SN - 0019-9567

VL - 76

SP - 2212

EP - 2218

JO - Infection and Immunity

JF - Infection and Immunity

IS - 5

ER -

Hepatosplenomegaly is associated with low regulatory and Th2 responses to schistosome antigens in childhood schistosomiasis and malaria coinfection

Abstract

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