Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice

TY - JOUR

T1 - Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice

AU - Christoffersen, Christina

AU - Bartels, E D

AU - Nielsen, L B

PY - 2006/2

Y1 - 2006/2

N2 - Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.

AB - Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.

KW - Animals

KW - Atrial Natriuretic Factor

KW - Diabetes Mellitus, Experimental

KW - Diabetes Mellitus, Type 1

KW - Guanylate Cyclase

KW - Heart

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Natriuretic Peptide, Brain

KW - Natriuretic Peptide, C-Type

KW - Natriuretic Peptides

KW - RNA, Messenger

KW - Receptors, Atrial Natriuretic Factor

KW - Up-Regulation

U2 - 10.1111/j.1365-2362.2006.01596.x

DO - 10.1111/j.1365-2362.2006.01596.x

M3 - Journal article

C2 - 16436087

SN - 0014-2972

VL - 36

SP - 69

EP - 75

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 2

ER -