Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial

Magnus Thorsten Jensen; Christoph Kaiser; Karl Erik Sandsten; Hannes Alber; Maria Wanitschek; Allan Iversen; Jan Skov Jensen; Sune Pedersen; Rikke Soerensen; Hans Rickli; Marzena Zurek; Gregor Fahrni; Osmund Bertel; Stefano De Servi; Paul Erne; Matthias Pfisterer; Søren Galatius; for the BASKET-PROVE investigators

doi:10.1016/j.ijcard.2013.06.034

Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial

Magnus Thorsten Jensen, Christoph Kaiser, Karl Erik Sandsten, Hannes Alber, Maria Wanitschek, Allan Iversen, Jan Skov Jensen, Sune Pedersen, Rikke Soerensen, Hans Rickli, Marzena Zurek, Gregor Fahrni, Osmund Bertel, Stefano De Servi, Paul Erne, Matthias Pfisterer, Søren Galatius, for the BASKET-PROVE investigators

13 Citations (Scopus)

Abstract

Background Elevated heart rate (HR) is associated with mortality in a number of heart diseases. We examined the long-term prognostic significance of HR at discharge in a contemporary population of patients with stable angina (SAP), non-ST-segment elevation acute coronary syndromes (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI) revascularized with percutaneous coronary intervention (PCI). Methods Patients from the BASKET-PROVE trial, an 11-center randomized all-comers trial comparing bare-metal and drug-eluting stenting in large coronary vessels, were included. Discharge HR was determined from a resting ECG. Long-term outcomes (7 days to 2 years) were evaluated for all-cause mortality and cardiovascular death and non-fatal myocardial infarction. Results A total of 2029 patients with sinus rhythm were included, 722 (35.6%) SAP, 647 (31.9%) NSTE-ACS, and 660 (32.5%) STEMI. Elevated discharge HR was associated significantly with all-cause mortality: when compared to a reference of < 60 beats per minute (bpm), the adjusted hazard ratios were (95% CI) 4.5 (1.5-13.5, p = 0.006) for 60-69 bpm, 3.8 (1.2-11.9, p = 0.022) for 70-79 bpm, 4.3 (1.2-15.6, p = 0.025) for 80-89 bpm, and 16.9 (5.2-55.0, p < 0.001) for > 90 bpm. For cardiovascular death/myocardial infarction, a discharge HR > 90 bpm was associated with a hazard ratio of 6.2 (2.5-15.5, p < 0.001) compared to a HR < 60 bpm. No interaction was found for disease presentation, diabetes or betablocker use. Conclusion In patients revascularized with PCI for stable angina or acute coronary syndromes an elevated discharge HR was independently associated with poor prognosis. Conversely, a HR < 60 bpm at discharge was associated with a good long-term prognosis irrespective of indication for PCI.

Original language	English
Journal	International Journal of Cardiology
Volume	168
Issue number	4
Pages (from-to)	3802–3806
Number of pages	5
ISSN	0167-5273
DOIs	https://doi.org/10.1016/j.ijcard.2013.06.034
Publication status	Published - 9 Oct 2013

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Jensen, M. T., Kaiser, C., Sandsten, K. E., Alber, H., Wanitschek, M., Iversen, A., Jensen, J. S., Pedersen, S., Soerensen, R., Rickli, H., Zurek, M., Fahrni, G., Bertel, O., De Servi, S., Erne, P., Pfisterer, M., Galatius, S., & investigators, F. T. BASKET-PROVE. (2013). Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial. International Journal of Cardiology, 168(4), 3802–3806. https://doi.org/10.1016/j.ijcard.2013.06.034

Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial. / Jensen, Magnus Thorsten; Kaiser, Christoph; Sandsten, Karl Erik et al.

In: International Journal of Cardiology, Vol. 168, No. 4, 09.10.2013, p. 3802–3806.

Research output: Contribution to journal › Journal article › Research › peer-review

Jensen, MT, Kaiser, C, Sandsten, KE, Alber, H, Wanitschek, M, Iversen, A, Jensen, JS, Pedersen, S, Soerensen, R, Rickli, H, Zurek, M, Fahrni, G, Bertel, O, De Servi, S, Erne, P, Pfisterer, M, Galatius, S & investigators, FTBASKET-PROVE 2013, 'Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial', International Journal of Cardiology, vol. 168, no. 4, pp. 3802–3806. https://doi.org/10.1016/j.ijcard.2013.06.034

@article{d8c33aa046844754b148a5e5d3040ef9,

title = "Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial",

abstract = "Background Elevated heart rate (HR) is associated with mortality in a number of heart diseases. We examined the long-term prognostic significance of HR at discharge in a contemporary population of patients with stable angina (SAP), non-ST-segment elevation acute coronary syndromes (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI) revascularized with percutaneous coronary intervention (PCI). Methods Patients from the BASKET-PROVE trial, an 11-center randomized all-comers trial comparing bare-metal and drug-eluting stenting in large coronary vessels, were included. Discharge HR was determined from a resting ECG. Long-term outcomes (7 days to 2 years) were evaluated for all-cause mortality and cardiovascular death and non-fatal myocardial infarction. Results A total of 2029 patients with sinus rhythm were included, 722 (35.6%) SAP, 647 (31.9%) NSTE-ACS, and 660 (32.5%) STEMI. Elevated discharge HR was associated significantly with all-cause mortality: when compared to a reference of < 60 beats per minute (bpm), the adjusted hazard ratios were (95% CI) 4.5 (1.5-13.5, p = 0.006) for 60-69 bpm, 3.8 (1.2-11.9, p = 0.022) for 70-79 bpm, 4.3 (1.2-15.6, p = 0.025) for 80-89 bpm, and 16.9 (5.2-55.0, p < 0.001) for > 90 bpm. For cardiovascular death/myocardial infarction, a discharge HR > 90 bpm was associated with a hazard ratio of 6.2 (2.5-15.5, p < 0.001) compared to a HR < 60 bpm. No interaction was found for disease presentation, diabetes or betablocker use. Conclusion In patients revascularized with PCI for stable angina or acute coronary syndromes an elevated discharge HR was independently associated with poor prognosis. Conversely, a HR < 60 bpm at discharge was associated with a good long-term prognosis irrespective of indication for PCI.",

author = "Jensen, {Magnus Thorsten} and Christoph Kaiser and Sandsten, {Karl Erik} and Hannes Alber and Maria Wanitschek and Allan Iversen and Jensen, {Jan Skov} and Sune Pedersen and Rikke Soerensen and Hans Rickli and Marzena Zurek and Gregor Fahrni and Osmund Bertel and {De Servi}, Stefano and Paul Erne and Matthias Pfisterer and S{\o}ren Galatius and investigators, {for the BASKET-PROVE}",

year = "2013",

month = oct,

day = "9",

doi = "10.1016/j.ijcard.2013.06.034",

language = "English",

volume = "168",

pages = "3802–3806",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "4",

}

TY - JOUR

T1 - Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial

AU - Jensen, Magnus Thorsten

AU - Kaiser, Christoph

AU - Sandsten, Karl Erik

AU - Alber, Hannes

AU - Wanitschek, Maria

AU - Iversen, Allan

AU - Jensen, Jan Skov

AU - Pedersen, Sune

AU - Soerensen, Rikke

AU - Rickli, Hans

AU - Zurek, Marzena

AU - Fahrni, Gregor

AU - Bertel, Osmund

AU - De Servi, Stefano

AU - Erne, Paul

AU - Pfisterer, Matthias

AU - Galatius, Søren

AU - investigators, for the BASKET-PROVE

PY - 2013/10/9

Y1 - 2013/10/9

N2 - Background Elevated heart rate (HR) is associated with mortality in a number of heart diseases. We examined the long-term prognostic significance of HR at discharge in a contemporary population of patients with stable angina (SAP), non-ST-segment elevation acute coronary syndromes (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI) revascularized with percutaneous coronary intervention (PCI). Methods Patients from the BASKET-PROVE trial, an 11-center randomized all-comers trial comparing bare-metal and drug-eluting stenting in large coronary vessels, were included. Discharge HR was determined from a resting ECG. Long-term outcomes (7 days to 2 years) were evaluated for all-cause mortality and cardiovascular death and non-fatal myocardial infarction. Results A total of 2029 patients with sinus rhythm were included, 722 (35.6%) SAP, 647 (31.9%) NSTE-ACS, and 660 (32.5%) STEMI. Elevated discharge HR was associated significantly with all-cause mortality: when compared to a reference of < 60 beats per minute (bpm), the adjusted hazard ratios were (95% CI) 4.5 (1.5-13.5, p = 0.006) for 60-69 bpm, 3.8 (1.2-11.9, p = 0.022) for 70-79 bpm, 4.3 (1.2-15.6, p = 0.025) for 80-89 bpm, and 16.9 (5.2-55.0, p < 0.001) for > 90 bpm. For cardiovascular death/myocardial infarction, a discharge HR > 90 bpm was associated with a hazard ratio of 6.2 (2.5-15.5, p < 0.001) compared to a HR < 60 bpm. No interaction was found for disease presentation, diabetes or betablocker use. Conclusion In patients revascularized with PCI for stable angina or acute coronary syndromes an elevated discharge HR was independently associated with poor prognosis. Conversely, a HR < 60 bpm at discharge was associated with a good long-term prognosis irrespective of indication for PCI.

AB - Background Elevated heart rate (HR) is associated with mortality in a number of heart diseases. We examined the long-term prognostic significance of HR at discharge in a contemporary population of patients with stable angina (SAP), non-ST-segment elevation acute coronary syndromes (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI) revascularized with percutaneous coronary intervention (PCI). Methods Patients from the BASKET-PROVE trial, an 11-center randomized all-comers trial comparing bare-metal and drug-eluting stenting in large coronary vessels, were included. Discharge HR was determined from a resting ECG. Long-term outcomes (7 days to 2 years) were evaluated for all-cause mortality and cardiovascular death and non-fatal myocardial infarction. Results A total of 2029 patients with sinus rhythm were included, 722 (35.6%) SAP, 647 (31.9%) NSTE-ACS, and 660 (32.5%) STEMI. Elevated discharge HR was associated significantly with all-cause mortality: when compared to a reference of < 60 beats per minute (bpm), the adjusted hazard ratios were (95% CI) 4.5 (1.5-13.5, p = 0.006) for 60-69 bpm, 3.8 (1.2-11.9, p = 0.022) for 70-79 bpm, 4.3 (1.2-15.6, p = 0.025) for 80-89 bpm, and 16.9 (5.2-55.0, p < 0.001) for > 90 bpm. For cardiovascular death/myocardial infarction, a discharge HR > 90 bpm was associated with a hazard ratio of 6.2 (2.5-15.5, p < 0.001) compared to a HR < 60 bpm. No interaction was found for disease presentation, diabetes or betablocker use. Conclusion In patients revascularized with PCI for stable angina or acute coronary syndromes an elevated discharge HR was independently associated with poor prognosis. Conversely, a HR < 60 bpm at discharge was associated with a good long-term prognosis irrespective of indication for PCI.

U2 - 10.1016/j.ijcard.2013.06.034

DO - 10.1016/j.ijcard.2013.06.034

M3 - Journal article

C2 - 23849965

SN - 0167-5273

VL - 168

SP - 3802

EP - 3806

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 4

ER -

Heart rate at discharge and long-term prognosis following percutaneous coronary intervention in stable and acute coronary syndromes — results from the BASKET PROVE trial

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