Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Pooja Dewan; Pardeep S. Jhund; Li Shen; Mark C. Petrie; William T. Abraham; M. Atif Ali; Chen‐huan Chen; Akshay S. Desai; Kenneth Dickstein; Jun Huang; Songsak Kiatchoosakun; Kee‐sik Kim; Lars Køber; Wen‐ter Lai; Yuhua Liao; Ulrik M. Mogensen; Byung‐hee Oh; Milton Packer; Jean L. Rouleau; Victor Shi; Antonio S. Sibulo; Scott D. Solomon; Piyamitr Sritara; Karl Swedberg; Hiroyuki Tsutsui; Michael R. Zile; John J.v. Mcmurray

doi:10.1002/ejhf.2019.21.issue-5

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Pooja Dewan, Pardeep S. Jhund, Li Shen, Mark C. Petrie, William T. Abraham, M. Atif Ali, Chen‐huan Chen, Akshay S. Desai, Kenneth Dickstein, Jun Huang, Songsak Kiatchoosakun, Kee‐sik Kim, Lars Køber, Wen‐ter Lai, Yuhua Liao, Ulrik M. Mogensen, Byung‐hee Oh, Milton Packer, Jean L. Rouleau, Victor ShiAntonio S. Sibulo, Scott D. Solomon, Piyamitr Sritara, Karl Swedberg, Hiroyuki Tsutsui, Michael R. Zile, John J.v. Mcmurray

Department of Clinical Medicine

13 Citations (Scopus)

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Abstract

Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.

Original language	English
Journal	European Journal of Heart Failure
Volume	21
Issue number	5
Pages (from-to)	577-587
ISSN	1388-9842
DOIs	https://doi.org/10.1002/ejhf.2019.21.issue-5
Publication status	Published - May 2019

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Dewan, P., Jhund, P. S., Shen, L., Petrie, M. C., Abraham, W. T., Atif Ali, M., Chen, C., Desai, A. S., Dickstein, K., Huang, J., Kiatchoosakun, S., Kim, K., Køber, L., Lai, W., Liao, Y., Mogensen, U. M., Oh, B., Packer, M., Rouleau, J. L., ... Mcmurray, J. J. V. (2019). Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas. European Journal of Heart Failure, 21(5), 577-587. https://doi.org/10.1002/ejhf.2019.21.issue-5

Heart failure with reduced ejection fraction : comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas. / Dewan, Pooja; Jhund, Pardeep S.; Shen, Li et al.

In: European Journal of Heart Failure, Vol. 21, No. 5, 05.2019, p. 577-587.

Research output: Contribution to journal › Journal article › Research › peer-review

Dewan, P, Jhund, PS, Shen, L, Petrie, MC, Abraham, WT, Atif Ali, M, Chen, C, Desai, AS, Dickstein, K, Huang, J, Kiatchoosakun, S, Kim, K, Køber, L, Lai, W, Liao, Y, Mogensen, UM, Oh, B, Packer, M, Rouleau, JL, Shi, V, Sibulo, AS, Solomon, SD, Sritara, P, Swedberg, K, Tsutsui, H, Zile, MR & Mcmurray, JJV 2019, 'Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas', European Journal of Heart Failure, vol. 21, no. 5, pp. 577-587. https://doi.org/10.1002/ejhf.2019.21.issue-5

@article{29e9cdc4d4d9425b8a8110c7b38e3317,

title = "Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas",

abstract = "Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.",

author = "Pooja Dewan and Jhund, {Pardeep S.} and Li Shen and Petrie, {Mark C.} and Abraham, {William T.} and {Atif Ali}, M. and Chen‐huan Chen and Desai, {Akshay S.} and Kenneth Dickstein and Jun Huang and Songsak Kiatchoosakun and Kee‐sik Kim and Lars K{\o}ber and Wen‐ter Lai and Yuhua Liao and Mogensen, {Ulrik M.} and Byung‐hee Oh and Milton Packer and Rouleau, {Jean L.} and Victor Shi and Sibulo, {Antonio S.} and Solomon, {Scott D.} and Piyamitr Sritara and Karl Swedberg and Hiroyuki Tsutsui and Zile, {Michael R.} and Mcmurray, {John J.v.}",

year = "2019",

month = may,

doi = "10.1002/ejhf.2019.21.issue-5",

language = "English",

volume = "21",

pages = "577--587",

journal = "European Journal of Heart Failure, Supplement",

issn = "1567-4215",

publisher = "JohnWiley & Sons Ltd",

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TY - JOUR

T1 - Heart failure with reduced ejection fraction

T2 - comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

AU - Dewan, Pooja

AU - Jhund, Pardeep S.

AU - Shen, Li

AU - Petrie, Mark C.

AU - Abraham, William T.

AU - Atif Ali, M.

AU - Chen, Chen‐huan

AU - Desai, Akshay S.

AU - Dickstein, Kenneth

AU - Huang, Jun

AU - Kiatchoosakun, Songsak

AU - Kim, Kee‐sik

AU - Køber, Lars

AU - Lai, Wen‐ter

AU - Liao, Yuhua

AU - Mogensen, Ulrik M.

AU - Oh, Byung‐hee

AU - Packer, Milton

AU - Rouleau, Jean L.

AU - Shi, Victor

AU - Sibulo, Antonio S.

AU - Solomon, Scott D.

AU - Sritara, Piyamitr

AU - Swedberg, Karl

AU - Tsutsui, Hiroyuki

AU - Zile, Michael R.

AU - Mcmurray, John J.v.

PY - 2019/5

Y1 - 2019/5

N2 - Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.

AB - Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.

U2 - 10.1002/ejhf.2019.21.issue-5

DO - 10.1002/ejhf.2019.21.issue-5

M3 - Journal article

SN - 1567-4215

VL - 21

SP - 577

EP - 587

JO - European Journal of Heart Failure, Supplement

JF - European Journal of Heart Failure, Supplement

IS - 5

ER -

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

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