Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition

F. Zannad; W.G. Stough; B. Pitt; J.G. Cleland; K.F. Adams; N.L. Geller; B.A. Kirwan; F. Follath; Christian Tobias Torp-Pedersen

Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition

F. Zannad, W.G. Stough, B. Pitt, J.G. Cleland, K.F. Adams, N.L. Geller, B.A. Kirwan, F. Follath, Christian Tobias Torp-Pedersen

34 Citations (Scopus)

Abstract

Specific criteria have been established to define the occurrence of myocardial infarction (MI) and stroke in cardiovascular clinical trials, but there is not a consistent definition for heart failure. Heart failure events appear to occur at a rate that is similar to stroke and MI in trials of hypertension, hyperlipidaemia, diabetes, and coronary heart disease, yet a consistent approach to defining heart failure events has not yet been realized. The wide range of definitions used in clinical trials makes it difficult to interpret new data in the context of existing literature. This inconsistency has led to challenges in determining the incidence of heart failure in cardiovascular studies and the effects of interventions on these endpoints. This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue
Udgivelsesdato: 2008/2

Original language	English
Journal	European Heart Journal
Volume	29
Issue number	3
Pages (from-to)	413-421
Number of pages	8
ISSN	0195-668X
Publication status	Published - 2008

Cite this

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title = "Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition",

abstract = "Specific criteria have been established to define the occurrence of myocardial infarction (MI) and stroke in cardiovascular clinical trials, but there is not a consistent definition for heart failure. Heart failure events appear to occur at a rate that is similar to stroke and MI in trials of hypertension, hyperlipidaemia, diabetes, and coronary heart disease, yet a consistent approach to defining heart failure events has not yet been realized. The wide range of definitions used in clinical trials makes it difficult to interpret new data in the context of existing literature. This inconsistency has led to challenges in determining the incidence of heart failure in cardiovascular studies and the effects of interventions on these endpoints. This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue Udgivelsesdato: 2008/2",

author = "F. Zannad and W.G. Stough and B. Pitt and J.G. Cleland and K.F. Adams and N.L. Geller and B.A. Kirwan and F. Follath and Torp-Pedersen, {Christian Tobias}",

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T1 - Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition

AU - Zannad, F.

AU - Stough, W.G.

AU - Pitt, B.

AU - Cleland, J.G.

AU - Adams, K.F.

AU - Geller, N.L.

AU - Kirwan, B.A.

AU - Follath, F.

AU - Torp-Pedersen, Christian Tobias

PY - 2008

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N2 - Specific criteria have been established to define the occurrence of myocardial infarction (MI) and stroke in cardiovascular clinical trials, but there is not a consistent definition for heart failure. Heart failure events appear to occur at a rate that is similar to stroke and MI in trials of hypertension, hyperlipidaemia, diabetes, and coronary heart disease, yet a consistent approach to defining heart failure events has not yet been realized. The wide range of definitions used in clinical trials makes it difficult to interpret new data in the context of existing literature. This inconsistency has led to challenges in determining the incidence of heart failure in cardiovascular studies and the effects of interventions on these endpoints. This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue Udgivelsesdato: 2008/2

AB - Specific criteria have been established to define the occurrence of myocardial infarction (MI) and stroke in cardiovascular clinical trials, but there is not a consistent definition for heart failure. Heart failure events appear to occur at a rate that is similar to stroke and MI in trials of hypertension, hyperlipidaemia, diabetes, and coronary heart disease, yet a consistent approach to defining heart failure events has not yet been realized. The wide range of definitions used in clinical trials makes it difficult to interpret new data in the context of existing literature. This inconsistency has led to challenges in determining the incidence of heart failure in cardiovascular studies and the effects of interventions on these endpoints. This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue Udgivelsesdato: 2008/2

M3 - Journal article

SN - 0195-668X

VL - 29

SP - 413

EP - 421

JO - European Heart Journal

JF - European Heart Journal

IS - 3

ER -