Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study

J Burisch; P Weimers; N Pedersen; S Cukovic-Cavka; B Vucelic; I Kaimakliotis; D Duricova; M Bortlik; O Shonová; Ida Vind; S Avnstrøm; N Thorsgaard; S Krabbe; Vinnie Andersen; J F Dahlerup; J Kjeldsen; R Salupere; J Olsen; K R Nielsen; P Manninen; P Collin; K H Katsanos; E V Tsianos; K Ladefoged; L Lakatos; G Ragnarsson; E Björnsson; Y Bailey; C O'Morain; D Schwartz; S Odes; D Valpiani; M C Boni; L Jonaitis; L Kupcinskas; S Turcan; L Barros; F Magro; D Lazar; A Goldis; I Nikulina; E Belousova; A Fernandez; L Sanroman; S Almer; Y Zhulina; J Halfvarson; N Arebi; T Diggory; P Munkholm; EpiCom Group

doi:10.1016/j.crohns.2014.01.028

Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study

J Burisch, P Weimers, N Pedersen, S Cukovic-Cavka, B Vucelic, I Kaimakliotis, D Duricova, M Bortlik, O Shonová, Ida Vind, S Avnstrøm, N Thorsgaard, S Krabbe, Vinnie Andersen, J F Dahlerup, J Kjeldsen, R Salupere, J Olsen, K R Nielsen, P ManninenP Collin, K H Katsanos, E V Tsianos, K Ladefoged, L Lakatos, G Ragnarsson, E Björnsson, Y Bailey, C O'Morain, D Schwartz, S Odes, D Valpiani, M C Boni, L Jonaitis, L Kupcinskas, S Turcan, L Barros, F Magro, D Lazar, A Goldis, I Nikulina, E Belousova, A Fernandez, L Sanroman, S Almer, Y Zhulina, J Halfvarson, N Arebi, T Diggory, P Munkholm, EpiCom Group

Department of Clinical Medicine

39 Citations (Scopus)

Abstract

BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.

METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.

RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.

CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

Original language	English
Journal	Journal of Crohn's & colitis
Volume	8
Pages (from-to)	1030-1042
Number of pages	13
ISSN	1873-9946
DOIs	https://doi.org/10.1016/j.crohns.2014.01.028
Publication status	Published - 1 Sept 2014

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Digestive System Surgical Procedures
Disease Management
Europe
Female
Follow-Up Studies
Humans
Inflammatory Bowel Diseases
Male
Middle Aged
Morbidity
Population Surveillance
Prognosis
Prospective Studies
Quality of Life
Questionnaires
Young Adult

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10.1016/j.crohns.2014.01.028

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Burisch, J., Weimers, P., Pedersen, N., Cukovic-Cavka, S., Vucelic, B., Kaimakliotis, I., Duricova, D., Bortlik, M., Shonová, O., Vind, I., Avnstrøm, S., Thorsgaard, N., Krabbe, S., Andersen, V., Dahlerup, J. F., Kjeldsen, J., Salupere, R., Olsen, J., Nielsen, K. R., ... EpiCom Group (2014). Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study. Journal of Crohn's & colitis, 8, 1030-1042. https://doi.org/10.1016/j.crohns.2014.01.028

Research output: Contribution to journal › Journal article › Research › peer-review

Burisch, J, Weimers, P, Pedersen, N, Cukovic-Cavka, S, Vucelic, B, Kaimakliotis, I, Duricova, D, Bortlik, M, Shonová, O, Vind, I, Avnstrøm, S, Thorsgaard, N, Krabbe, S, Andersen, V, Dahlerup, JF, Kjeldsen, J, Salupere, R, Olsen, J, Nielsen, KR, Manninen, P, Collin, P, Katsanos, KH, Tsianos, EV, Ladefoged, K, Lakatos, L, Ragnarsson, G, Björnsson, E, Bailey, Y, O'Morain, C, Schwartz, D, Odes, S, Valpiani, D, Boni, MC, Jonaitis, L, Kupcinskas, L, Turcan, S, Barros, L, Magro, F, Lazar, D, Goldis, A, Nikulina, I, Belousova, E, Fernandez, A, Sanroman, L, Almer, S, Zhulina, Y, Halfvarson, J, Arebi, N, Diggory, T, Munkholm, P & EpiCom Group 2014, 'Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study', Journal of Crohn's & colitis, vol. 8, pp. 1030-1042. https://doi.org/10.1016/j.crohns.2014.01.028

Burisch J, Weimers P, Pedersen N, Cukovic-Cavka S, Vucelic B, Kaimakliotis I et al. Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study. Journal of Crohn's & colitis. 2014 Sept 1;8:1030-1042. doi: 10.1016/j.crohns.2014.01.028

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title = "Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study",

abstract = "BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Digestive System Surgical Procedures, Disease Management, Europe, Female, Follow-Up Studies, Humans, Inflammatory Bowel Diseases, Male, Middle Aged, Morbidity, Population Surveillance, Prognosis, Prospective Studies, Quality of Life, Questionnaires, Young Adult",

author = "J Burisch and P Weimers and N Pedersen and S Cukovic-Cavka and B Vucelic and I Kaimakliotis and D Duricova and M Bortlik and O Shonov{\'a} and Ida Vind and S Avnstr{\o}m and N Thorsgaard and S Krabbe and Vinnie Andersen and Dahlerup, {J F} and J Kjeldsen and R Salupere and J Olsen and Nielsen, {K R} and P Manninen and P Collin and Katsanos, {K H} and Tsianos, {E V} and K Ladefoged and L Lakatos and G Ragnarsson and E Bj{\"o}rnsson and Y Bailey and C O'Morain and D Schwartz and S Odes and D Valpiani and Boni, {M C} and L Jonaitis and L Kupcinskas and S Turcan and L Barros and F Magro and D Lazar and A Goldis and I Nikulina and E Belousova and A Fernandez and L Sanroman and S Almer and Y Zhulina and J Halfvarson and N Arebi and T Diggory and P Munkholm and {EpiCom Group}",

year = "2014",

month = sep,

day = "1",

doi = "10.1016/j.crohns.2014.01.028",

language = "English",

volume = "8",

pages = "1030--1042",

journal = "Journal of Crohn's & colitis",

issn = "1873-9946",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease

T2 - An ECCO-EpiCom study

AU - Burisch, J

AU - Weimers, P

AU - Pedersen, N

AU - Cukovic-Cavka, S

AU - Vucelic, B

AU - Kaimakliotis, I

AU - Duricova, D

AU - Bortlik, M

AU - Shonová, O

AU - Vind, Ida

AU - Avnstrøm, S

AU - Thorsgaard, N

AU - Krabbe, S

AU - Andersen, Vinnie

AU - Dahlerup, J F

AU - Kjeldsen, J

AU - Salupere, R

AU - Olsen, J

AU - Nielsen, K R

AU - Manninen, P

AU - Collin, P

AU - Katsanos, K H

AU - Tsianos, E V

AU - Ladefoged, K

AU - Lakatos, L

AU - Ragnarsson, G

AU - Björnsson, E

AU - Bailey, Y

AU - O'Morain, C

AU - Schwartz, D

AU - Odes, S

AU - Valpiani, D

AU - Boni, M C

AU - Jonaitis, L

AU - Kupcinskas, L

AU - Turcan, S

AU - Barros, L

AU - Magro, F

AU - Lazar, D

AU - Goldis, A

AU - Nikulina, I

AU - Belousova, E

AU - Fernandez, A

AU - Sanroman, L

AU - Almer, S

AU - Zhulina, Y

AU - Halfvarson, J

AU - Arebi, N

AU - Diggory, T

AU - Munkholm, P

AU - EpiCom Group

PY - 2014/9/1

Y1 - 2014/9/1

N2 - BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

AB - BACKGROUND & AIMS: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.METHODS: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.RESULTS: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.CONCLUSION: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Digestive System Surgical Procedures

KW - Disease Management

KW - Europe

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Inflammatory Bowel Diseases

KW - Male

KW - Middle Aged

KW - Morbidity

KW - Population Surveillance

KW - Prognosis

KW - Prospective Studies

KW - Quality of Life

KW - Questionnaires

KW - Young Adult

U2 - 10.1016/j.crohns.2014.01.028

DO - 10.1016/j.crohns.2014.01.028

M3 - Journal article

C2 - 24560877

SN - 1873-9946

VL - 8

SP - 1030

EP - 1042

JO - Journal of Crohn's & colitis

JF - Journal of Crohn's & colitis

ER -

Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study

Abstract

Keywords

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