Head and neck cancer in HIV patients and their parents: a Danish cohort study

Frederik N Engsig; Jan Gerstoft; Gitte Kronborg; Carsten Schade Larsen; Gitte Pedersen; Court Pedersen; Niels Obel

doi:http://dx.doi.org/10.2147/CLEP.S19875

Head and neck cancer in HIV patients and their parents: a Danish cohort study

Frederik N Engsig, Jan Gerstoft, Gitte Kronborg, Carsten Schade Larsen, Gitte Pedersen, Court Pedersen, Niels Obel

21 Citations (Scopus)

Abstract

Background: The mechanism for the increased risk of head and neck cancer (HNC) observed in HIV patients is controversial. We hypothesized that family-related risk factors increase the risk of HNC why we estimated the risk of this type of cancer in both HIV patients and their parents. Methods: We estimated the cumulative incidence and incidence rate ratios (IRRs) of HNCin 1) a population of all Danish HIV patients identified from the Danish HIV Cohort Study(n = 5053) and a cohort of population controls matched on age and gender (n = 50,530) (study period; 1995-2009) and 2) the parents of HIV patients and population controls (study period 1978-2009). To assess the possible impact of human papilloma virus (HPV)-associated cancers,the sites of squamous cell HNCs were categorized as HPV related, potentially HPV related, and potentially HPV unrelated. Results: Seventeen (0.3%) HIV patients vs 80 (0.2%) population controls were diagnosed with HNC cancer in the observation period. HIV patients had an increased risk of HNC (IRR 3.05 [95% CI 1.81-5.15]). The IRR was considerably increased in HIV patients older than 50 years (adjusted IRR; 4.58 [95% CI 2.24-9.35]), diagnosed after 1995 (adjusted IRR 6.31[95% CI 2.82-14.08]), previous or current smoker (adjusted IRR 4.51 [95% CI 2.47-8.23]), with baseline CD4 count 350 cells/μL (adjusted IRR; 3.89 [95% CI 1.95-7.78]), and men heterosexually infected with HIV (adjusted IRR 5.54 [95% CI 1.96-15.66]). Fifteen (83%) of the HIV patients diagnosed with HNC were current or former smokers. The IRR of squamous cell HNC in HIV patients was high at HPV-relate sites, potentially HPV-related sites, and potentially HPV-unrelated sites. Both fathers and mothers of HIV patients had an increased risk of HNC (adjusted IRR for fathers 1.78 [95% CI 1.28-2.48], adjusted IRR for mothers 2.07 [95% CI 1.05-4.09]). Conclusion: HIV appears to be a marker of behavioral or family-related risk factors that affect the incidence of HNC in HIV patients.

Original language	English
Journal	Clinical Epidemiology
Volume	3
Pages (from-to)	217-27
Number of pages	11
ISSN	1179-1349
DOIs	https://doi.org/10.2147/CLEP.S19875
Publication status	Published - 21 Jul 2011

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@article{9d868a21d3ba4c488836410059211a56,

title = "Head and neck cancer in HIV patients and their parents: a Danish cohort study",

abstract = "Background: The mechanism for the increased risk of head and neck cancer (HNC) observed in HIV patients is controversial. We hypothesized that family-related risk factors increase the risk of HNC why we estimated the risk of this type of cancer in both HIV patients and their parents. Methods: We estimated the cumulative incidence and incidence rate ratios (IRRs) of HNCin 1) a population of all Danish HIV patients identified from the Danish HIV Cohort Study(n = 5053) and a cohort of population controls matched on age and gender (n = 50,530) (study period; 1995-2009) and 2) the parents of HIV patients and population controls (study period 1978-2009). To assess the possible impact of human papilloma virus (HPV)-associated cancers,the sites of squamous cell HNCs were categorized as HPV related, potentially HPV related, and potentially HPV unrelated. Results: Seventeen (0.3%) HIV patients vs 80 (0.2%) population controls were diagnosed with HNC cancer in the observation period. HIV patients had an increased risk of HNC (IRR 3.05 [95% CI 1.81-5.15]). The IRR was considerably increased in HIV patients older than 50 years (adjusted IRR; 4.58 [95% CI 2.24-9.35]), diagnosed after 1995 (adjusted IRR 6.31[95% CI 2.82-14.08]), previous or current smoker (adjusted IRR 4.51 [95% CI 2.47-8.23]), with baseline CD4 count 350 cells/μL (adjusted IRR; 3.89 [95% CI 1.95-7.78]), and men heterosexually infected with HIV (adjusted IRR 5.54 [95% CI 1.96-15.66]). Fifteen (83%) of the HIV patients diagnosed with HNC were current or former smokers. The IRR of squamous cell HNC in HIV patients was high at HPV-relate sites, potentially HPV-related sites, and potentially HPV-unrelated sites. Both fathers and mothers of HIV patients had an increased risk of HNC (adjusted IRR for fathers 1.78 [95% CI 1.28-2.48], adjusted IRR for mothers 2.07 [95% CI 1.05-4.09]). Conclusion: HIV appears to be a marker of behavioral or family-related risk factors that affect the incidence of HNC in HIV patients.",

author = "Engsig, {Frederik N} and Jan Gerstoft and Gitte Kronborg and Larsen, {Carsten Schade} and Gitte Pedersen and Court Pedersen and Niels Obel",

year = "2011",

month = jul,

day = "21",

doi = "http://dx.doi.org/10.2147/CLEP.S19875",

language = "English",

volume = "3",

pages = "217--27",

journal = "Clinical Epidemiology",

issn = "1179-1349",

publisher = "Dove Medical Press Ltd",

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TY - JOUR

T1 - Head and neck cancer in HIV patients and their parents: a Danish cohort study

AU - Engsig, Frederik N

AU - Gerstoft, Jan

AU - Kronborg, Gitte

AU - Larsen, Carsten Schade

AU - Pedersen, Gitte

AU - Pedersen, Court

AU - Obel, Niels

PY - 2011/7/21

Y1 - 2011/7/21

N2 - Background: The mechanism for the increased risk of head and neck cancer (HNC) observed in HIV patients is controversial. We hypothesized that family-related risk factors increase the risk of HNC why we estimated the risk of this type of cancer in both HIV patients and their parents. Methods: We estimated the cumulative incidence and incidence rate ratios (IRRs) of HNCin 1) a population of all Danish HIV patients identified from the Danish HIV Cohort Study(n = 5053) and a cohort of population controls matched on age and gender (n = 50,530) (study period; 1995-2009) and 2) the parents of HIV patients and population controls (study period 1978-2009). To assess the possible impact of human papilloma virus (HPV)-associated cancers,the sites of squamous cell HNCs were categorized as HPV related, potentially HPV related, and potentially HPV unrelated. Results: Seventeen (0.3%) HIV patients vs 80 (0.2%) population controls were diagnosed with HNC cancer in the observation period. HIV patients had an increased risk of HNC (IRR 3.05 [95% CI 1.81-5.15]). The IRR was considerably increased in HIV patients older than 50 years (adjusted IRR; 4.58 [95% CI 2.24-9.35]), diagnosed after 1995 (adjusted IRR 6.31[95% CI 2.82-14.08]), previous or current smoker (adjusted IRR 4.51 [95% CI 2.47-8.23]), with baseline CD4 count 350 cells/μL (adjusted IRR; 3.89 [95% CI 1.95-7.78]), and men heterosexually infected with HIV (adjusted IRR 5.54 [95% CI 1.96-15.66]). Fifteen (83%) of the HIV patients diagnosed with HNC were current or former smokers. The IRR of squamous cell HNC in HIV patients was high at HPV-relate sites, potentially HPV-related sites, and potentially HPV-unrelated sites. Both fathers and mothers of HIV patients had an increased risk of HNC (adjusted IRR for fathers 1.78 [95% CI 1.28-2.48], adjusted IRR for mothers 2.07 [95% CI 1.05-4.09]). Conclusion: HIV appears to be a marker of behavioral or family-related risk factors that affect the incidence of HNC in HIV patients.

AB - Background: The mechanism for the increased risk of head and neck cancer (HNC) observed in HIV patients is controversial. We hypothesized that family-related risk factors increase the risk of HNC why we estimated the risk of this type of cancer in both HIV patients and their parents. Methods: We estimated the cumulative incidence and incidence rate ratios (IRRs) of HNCin 1) a population of all Danish HIV patients identified from the Danish HIV Cohort Study(n = 5053) and a cohort of population controls matched on age and gender (n = 50,530) (study period; 1995-2009) and 2) the parents of HIV patients and population controls (study period 1978-2009). To assess the possible impact of human papilloma virus (HPV)-associated cancers,the sites of squamous cell HNCs were categorized as HPV related, potentially HPV related, and potentially HPV unrelated. Results: Seventeen (0.3%) HIV patients vs 80 (0.2%) population controls were diagnosed with HNC cancer in the observation period. HIV patients had an increased risk of HNC (IRR 3.05 [95% CI 1.81-5.15]). The IRR was considerably increased in HIV patients older than 50 years (adjusted IRR; 4.58 [95% CI 2.24-9.35]), diagnosed after 1995 (adjusted IRR 6.31[95% CI 2.82-14.08]), previous or current smoker (adjusted IRR 4.51 [95% CI 2.47-8.23]), with baseline CD4 count 350 cells/μL (adjusted IRR; 3.89 [95% CI 1.95-7.78]), and men heterosexually infected with HIV (adjusted IRR 5.54 [95% CI 1.96-15.66]). Fifteen (83%) of the HIV patients diagnosed with HNC were current or former smokers. The IRR of squamous cell HNC in HIV patients was high at HPV-relate sites, potentially HPV-related sites, and potentially HPV-unrelated sites. Both fathers and mothers of HIV patients had an increased risk of HNC (adjusted IRR for fathers 1.78 [95% CI 1.28-2.48], adjusted IRR for mothers 2.07 [95% CI 1.05-4.09]). Conclusion: HIV appears to be a marker of behavioral or family-related risk factors that affect the incidence of HNC in HIV patients.

U2 - http://dx.doi.org/10.2147/CLEP.S19875

DO - http://dx.doi.org/10.2147/CLEP.S19875

M3 - Journal article

SN - 1179-1349

VL - 3

SP - 217

EP - 227

JO - Clinical Epidemiology

JF - Clinical Epidemiology

ER -

Head and neck cancer in HIV patients and their parents: a Danish cohort study

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