TY - JOUR
T1 - H-1 and N-15 resonance assignment of the second fibronectin type III module of the neural cell adhesion molecule
AU - Kiselyov, Vladislav V
AU - Berezin, Vladimir
AU - Bock, Elisabeth
AU - Poulsen, Flemming M
N1 - Keywords: Amino Acid Sequence; Carbon Isotopes; Fibronectins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Weight; Neural Cell Adhesion Molecules; Nitrogen Isotopes; Protein Structure, Tertiary
PY - 2008
Y1 - 2008
N2 - We report here the NMR assignment of the second fibronectin type III module of the neural cell adhesion molecule (NCAM). This module has previously been shown to interact with the fibroblast growth factor receptor (FGFR), and the FGFR-binding site was mapped by NMR to the FG-loop region of the module. The FG-loop region also contains a putative nucleotide-binding motif, which was shown by NMR to interact with ATP. Furthermore, ATP was demonstrated to inhibit binding of the second F3 module of NCAM to FGFR.
AB - We report here the NMR assignment of the second fibronectin type III module of the neural cell adhesion molecule (NCAM). This module has previously been shown to interact with the fibroblast growth factor receptor (FGFR), and the FGFR-binding site was mapped by NMR to the FG-loop region of the module. The FG-loop region also contains a putative nucleotide-binding motif, which was shown by NMR to interact with ATP. Furthermore, ATP was demonstrated to inhibit binding of the second F3 module of NCAM to FGFR.
U2 - 10.1007/s12104-008-9113-9
DO - 10.1007/s12104-008-9113-9
M3 - Journal article
C2 - 19636897
SN - 1874-2718
VL - 2
SP - 171
EP - 173
JO - Biomolecular N M R Assignments
JF - Biomolecular N M R Assignments
IS - 2
ER -