Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

Ruixin Liu; Jie Hong; Xiaoqiang Xu; Qiang Feng; Dongya Zhang; Yanyun Gu; Juan Shi; Shaoqian Zhao; Wen Liu; Xiaokai Wang; Huihua Xia; Zhipeng Liu; Bin Cui; Peiwen Liang; Liuqing Xi; Jiabin Jin; Xiayang Ying; Xiaolin Wang; Xinjie Zhao; Wanyu Li; Huijue Jia; Zhou Lan; Fengyu Li; Rui Wang; Yingkai Sun; Minglan Yang; Yuxin Shen; Zhuye Jie; Junhua Li; Xiaomin Chen; Huanzi Zhong; Hailiang Xie; Yifei Zhang; Weiqiong Gu; Xiaxing Deng; Baiyong Shen; Xun Xu; Huanming Yang; Guowang Xu; Yufang Bi; Shenghan Lai; Jian Wang; Lu Qi; Lise Madsen; Jiqiu Wang; Guang Ning; Karsten Kristiansen; Weiqing Wang

doi:10.1038/nm.4358

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

Ruixin Liu, Jie Hong, Xiaoqiang Xu, Qiang Feng, Dongya Zhang, Yanyun Gu, Juan Shi, Shaoqian Zhao, Wen Liu, Xiaokai Wang, Huihua Xia, Zhipeng Liu, Bin Cui, Peiwen Liang, Liuqing Xi, Jiabin Jin, Xiayang Ying, Xiaolin Wang, Xinjie Zhao, Wanyu LiHuijue Jia, Zhou Lan, Fengyu Li, Rui Wang, Yingkai Sun, Minglan Yang, Yuxin Shen, Zhuye Jie, Junhua Li, Xiaomin Chen, Huanzi Zhong, Hailiang Xie, Yifei Zhang, Weiqiong Gu, Xiaxing Deng, Baiyong Shen, Xun Xu, Huanming Yang, Guowang Xu, Yufang Bi, Shenghan Lai, Jian Wang, Lu Qi, Lise Madsen, Jiqiu Wang, Guang Ning^*, Karsten Kristiansen, Weiqing Wang

^*Corresponding author for this work

Genome Research and Molecular Bio Medicine

397 Citations (Scopus)

Abstract

Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.

Original language	English
Journal	Nature Medicine
Volume	23
Issue number	7
Pages (from-to)	859-868
Number of pages	10
ISSN	1078-8956
DOIs	https://doi.org/10.1038/nm.4358
Publication status	Published - Jul 2017

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Liu, R, Hong, J, Xu, X, Feng, Q, Zhang, D, Gu, Y, Shi, J, Zhao, S, Liu, W, Wang, X, Xia, H, Liu, Z, Cui, B, Liang, P, Xi, L, Jin, J, Ying, X, Wang, X, Zhao, X, Li, W, Jia, H, Lan, Z, Li, F, Wang, R, Sun, Y, Yang, M, Shen, Y, Jie, Z, Li, J, Chen, X, Zhong, H, Xie, H, Zhang, Y, Gu, W, Deng, X, Shen, B, Xu, X, Yang, H, Xu, G, Bi, Y, Lai, S, Wang, J, Qi, L, Madsen, L, Wang, J, Ning, G, Kristiansen, K & Wang, W 2017, 'Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention', Nature Medicine, vol. 23, no. 7, pp. 859-868. https://doi.org/10.1038/nm.4358

@article{f359b607bded460ba4b7478e10a99bb3,

title = "Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention",

abstract = "Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.",

author = "Ruixin Liu and Jie Hong and Xiaoqiang Xu and Qiang Feng and Dongya Zhang and Yanyun Gu and Juan Shi and Shaoqian Zhao and Wen Liu and Xiaokai Wang and Huihua Xia and Zhipeng Liu and Bin Cui and Peiwen Liang and Liuqing Xi and Jiabin Jin and Xiayang Ying and Xiaolin Wang and Xinjie Zhao and Wanyu Li and Huijue Jia and Zhou Lan and Fengyu Li and Rui Wang and Yingkai Sun and Minglan Yang and Yuxin Shen and Zhuye Jie and Junhua Li and Xiaomin Chen and Huanzi Zhong and Hailiang Xie and Yifei Zhang and Weiqiong Gu and Xiaxing Deng and Baiyong Shen and Xun Xu and Huanming Yang and Guowang Xu and Yufang Bi and Shenghan Lai and Jian Wang and Lu Qi and Lise Madsen and Jiqiu Wang and Guang Ning and Karsten Kristiansen and Weiqing Wang",

year = "2017",

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doi = "10.1038/nm.4358",

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AU - Hong, Jie

AU - Xu, Xiaoqiang

AU - Feng, Qiang

AU - Zhang, Dongya

AU - Gu, Yanyun

AU - Shi, Juan

AU - Zhao, Shaoqian

AU - Liu, Wen

AU - Wang, Xiaokai

AU - Xia, Huihua

AU - Liu, Zhipeng

AU - Cui, Bin

AU - Liang, Peiwen

AU - Xi, Liuqing

AU - Jin, Jiabin

AU - Ying, Xiayang

AU - Wang, Xiaolin

AU - Zhao, Xinjie

AU - Li, Wanyu

AU - Jia, Huijue

AU - Lan, Zhou

AU - Li, Fengyu

AU - Wang, Rui

AU - Sun, Yingkai

AU - Yang, Minglan

AU - Shen, Yuxin

AU - Jie, Zhuye

AU - Li, Junhua

AU - Chen, Xiaomin

AU - Zhong, Huanzi

AU - Xie, Hailiang

AU - Zhang, Yifei

AU - Gu, Weiqiong

AU - Deng, Xiaxing

AU - Shen, Baiyong

AU - Xu, Xun

AU - Yang, Huanming

AU - Xu, Guowang

AU - Bi, Yufang

AU - Lai, Shenghan

AU - Wang, Jian

AU - Qi, Lu

AU - Madsen, Lise

AU - Wang, Jiqiu

AU - Ning, Guang

AU - Kristiansen, Karsten

AU - Wang, Weiqing

PY - 2017/7

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N2 - Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.

AB - Emerging evidence has linked the gut microbiome to human obesity. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. Consistently, gavage with B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron and the elevated serum glutamate concentration. Our findings identify previously unknown links between intestinal microbiota alterations, circulating amino acids and obesity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.

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JO - Nature Medicine

JF - Nature Medicine

IS - 7

ER -

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

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