Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae

Birgitte Regenberg, Thomas Grotkjaer, Ole Winther, Anders Fausbøll, Mats Akesson, Christoffer Bro, Lars Kai Hansen, Søren Brunak, Jens Nielsen

176 Citations (Scopus)

Abstract

Growth rate is central to the development of cells in all organisms. However, little is known about the impact of changing growth rates. We used continuous cultures to control growth rate and studied the transcriptional program of the model eukaryote Saccharomyces cerevisiae, with generation times varying between 2 and 35 hours.
Original languageEnglish
JournalGenome Biology (Online Edition)
Volume7
Issue number11
Pages (from-to)R107
ISSN1474-7596
DOIs
Publication statusPublished - 2006

Keywords

  • Cell Growth Processes
  • Chromosomes, Fungal
  • Cluster Analysis
  • Consensus Sequence
  • Ethanol
  • Gene Expression Profiling
  • Gene Expression Regulation, Fungal
  • Genes, Fungal
  • Open Reading Frames
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Replication Origin
  • Saccharomyces cerevisiae
  • Transcription, Genetic

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