Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

Claus Morten Larsen; M G Døssing; S Papa; G Franzoso; N Billestrup; Thomas Mandrup-Poulsen

doi:10.1007/s00125-006-0164-0

Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

Claus Morten Larsen, M G Døssing, S Papa, G Franzoso, N Billestrup, Thomas Mandrup-Poulsen

30 Citations (Scopus)

Abstract

IL-1beta is a candidate mediator of apoptotic beta cell destruction, a process that leads to type 1 diabetes and progression of type 2 diabetes. IL-1beta activates beta cell c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38, all of which are members of the mitogen-activated protein kinase (MAPK) family. Inhibition of JNK prevents IL-1beta-mediated beta cell destruction. In mouse embryo fibroblasts and 3DO T cells, overexpression of the gene encoding growth arrest and DNA-damage-inducible 45beta (Gadd45b) downregulates pro-apoptotic JNK signalling. The aim of this study was to investigate if Gadd45b prevents IL-1beta-induced beta cell MAPK signalling and apoptosis.

Original language	English
Journal	Diabetologia
Volume	49
Issue number	5
Pages (from-to)	980-9
Number of pages	10
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-006-0164-0
Publication status	Published - 1 May 2006

Keywords

3T3 Cells
Animals
Antigens, Differentiation
Apoptosis
Cell Division
DNA Damage
DNA Primers
Extracellular Signal-Regulated MAP Kinases
Gene Expression Regulation, Neoplastic
Insulin
Insulinoma
Interleukin-1
JNK Mitogen-Activated Protein Kinases
Mice
Pancreatic Neoplasms
Rats
Reverse Transcriptase Polymerase Chain Reaction
Transfection

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-006-0164-0

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Larsen, C. M., Døssing, M. G., Papa, S., Franzoso, G., Billestrup, N., & Mandrup-Poulsen, T. (2006). Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells. Diabetologia, 49(5), 980-9. https://doi.org/10.1007/s00125-006-0164-0

Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells. / Larsen, Claus Morten; Døssing, M G; Papa, S et al.
In: Diabetologia, Vol. 49, No. 5, 01.05.2006, p. 980-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Larsen, CM, Døssing, MG, Papa, S, Franzoso, G, Billestrup, N & Mandrup-Poulsen, T 2006, 'Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells', Diabetologia, vol. 49, no. 5, pp. 980-9. https://doi.org/10.1007/s00125-006-0164-0

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title = "Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells",

abstract = "IL-1beta is a candidate mediator of apoptotic beta cell destruction, a process that leads to type 1 diabetes and progression of type 2 diabetes. IL-1beta activates beta cell c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38, all of which are members of the mitogen-activated protein kinase (MAPK) family. Inhibition of JNK prevents IL-1beta-mediated beta cell destruction. In mouse embryo fibroblasts and 3DO T cells, overexpression of the gene encoding growth arrest and DNA-damage-inducible 45beta (Gadd45b) downregulates pro-apoptotic JNK signalling. The aim of this study was to investigate if Gadd45b prevents IL-1beta-induced beta cell MAPK signalling and apoptosis.",

keywords = "3T3 Cells, Animals, Antigens, Differentiation, Apoptosis, Cell Division, DNA Damage, DNA Primers, Extracellular Signal-Regulated MAP Kinases, Gene Expression Regulation, Neoplastic, Insulin, Insulinoma, Interleukin-1, JNK Mitogen-Activated Protein Kinases, Mice, Pancreatic Neoplasms, Rats, Reverse Transcriptase Polymerase Chain Reaction, Transfection",

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AU - Larsen, Claus Morten

AU - Døssing, M G

AU - Papa, S

AU - Franzoso, G

AU - Billestrup, N

AU - Mandrup-Poulsen, Thomas

PY - 2006/5/1

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N2 - IL-1beta is a candidate mediator of apoptotic beta cell destruction, a process that leads to type 1 diabetes and progression of type 2 diabetes. IL-1beta activates beta cell c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38, all of which are members of the mitogen-activated protein kinase (MAPK) family. Inhibition of JNK prevents IL-1beta-mediated beta cell destruction. In mouse embryo fibroblasts and 3DO T cells, overexpression of the gene encoding growth arrest and DNA-damage-inducible 45beta (Gadd45b) downregulates pro-apoptotic JNK signalling. The aim of this study was to investigate if Gadd45b prevents IL-1beta-induced beta cell MAPK signalling and apoptosis.

AB - IL-1beta is a candidate mediator of apoptotic beta cell destruction, a process that leads to type 1 diabetes and progression of type 2 diabetes. IL-1beta activates beta cell c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK) and p38, all of which are members of the mitogen-activated protein kinase (MAPK) family. Inhibition of JNK prevents IL-1beta-mediated beta cell destruction. In mouse embryo fibroblasts and 3DO T cells, overexpression of the gene encoding growth arrest and DNA-damage-inducible 45beta (Gadd45b) downregulates pro-apoptotic JNK signalling. The aim of this study was to investigate if Gadd45b prevents IL-1beta-induced beta cell MAPK signalling and apoptosis.

KW - 3T3 Cells

KW - Animals

KW - Antigens, Differentiation

KW - Apoptosis

KW - Cell Division

KW - DNA Damage

KW - DNA Primers

KW - Extracellular Signal-Regulated MAP Kinases

KW - Gene Expression Regulation, Neoplastic

KW - Insulin

KW - Insulinoma

KW - Interleukin-1

KW - JNK Mitogen-Activated Protein Kinases

KW - Mice

KW - Pancreatic Neoplasms

KW - Rats

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Transfection

U2 - 10.1007/s00125-006-0164-0

DO - 10.1007/s00125-006-0164-0

M3 - Journal article

C2 - 16528573

SN - 0012-186X

VL - 49

SP - 980

EP - 989

JO - Diabetologia

JF - Diabetologia

IS - 5

ER -

Growth arrest- and DNA-damage-inducible 45beta gene inhibits c-Jun N-terminal kinase and extracellular signal-regulated kinase and decreases IL-1beta-induced apoptosis in insulin-producing INS-1E cells

Abstract

Keywords

UN SDGs

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