Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain

Sarah Falk; Simone  Gallego-Pedersen; Nicolas Caesar Petersen

doi:10.21873/invivo.11102

Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain

Sarah Falk, Simone Gallego-Pedersen, Nicolas Caesar Petersen

3 Citations (Scopus)

Abstract

Despite affecting millions of people, chronic pain is generally treated insufficiently. A major point of focus has been the lack of translation from preclinical data to clinical results, with the predictive value of chronic pain models being a major concern. In contrast to current focus on stimulus-based nociceptive responses in preclinical research, development of behavioural tests designed to quantify suspension of normal behaviour is likely a more equivalent readout for human pain-assessment tests. In this study, we quantified grid-climbing behaviour as a non-stimulus-evoked behavioural test for potential use as a measure of neuropathic and cancer-induced bone pain in mice. In both models, the grid-climbing test demonstrated pain-related sparing of the affected leg during climbing. In both models, the behaviour was reversed by administration of morphine, suggesting that the observed behaviour was pain-specific.

Original language	English
Journal	In Vivo
Volume	31
Issue number	4
Pages (from-to)	619-623
ISSN	0258-851X
DOIs	https://doi.org/10.21873/invivo.11102
Publication status	Published - 1 Jul 2017

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Grid-climbing Behaviour as a Pain Measure for Cancer-induced Bone Pain and Neuropathic Pain

Abstract

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