GlycoDomainViewer: A bioinformatics tool for contextual exploration of glycoproteomes

TY - JOUR

T1 - GlycoDomainViewer

T2 - A bioinformatics tool for contextual exploration of glycoproteomes

AU - Joshi, Hiren J

AU - Jørgensen, Anja

AU - Schjoldager, Katrine T

AU - Halim, Adnan

AU - Dworkin, Leo A

AU - Steentoft, Catharina

AU - Wandall, Hans H

AU - Clausen, Henrik

AU - Vakhrushev, Sergey Y

N1 - © The Author(s) 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

PY - 2018/3/1

Y1 - 2018/3/1

N2 - The GlycoDomainViewer is a bioinformatic tool to aid in the mining of glycoproteomic datasets from different sources and facilitate incorporation of glycosylation into studies of protein structure and function. We present a version 2.0 of GlycoDomainViewer incorporating a number of advanced features, which enhances visibility and accessibility of the wealth of glycoproteomic data being generated. The GlycoDomainViewer enables visual exploration of glycoproteomic data, incorporating information from recent N- and O-glycoproteome studies on human and animal cell lines and some organs and body fluids. The initial data comprises sites of glycosylation for N-linked, O-GalNAc, O-Fucose, O-Xyl, O-Mannose (in both human and yeast) and cytosolic O-GlcNAc type. The data made available via this tool will be regularly updated to improve the coverage of known glycosylation sites and datasets, reflecting the advances currently being made in characterization of glycoproteomes. The tool is available at https://glycodomain.glycomics.ku.dk.

AB - The GlycoDomainViewer is a bioinformatic tool to aid in the mining of glycoproteomic datasets from different sources and facilitate incorporation of glycosylation into studies of protein structure and function. We present a version 2.0 of GlycoDomainViewer incorporating a number of advanced features, which enhances visibility and accessibility of the wealth of glycoproteomic data being generated. The GlycoDomainViewer enables visual exploration of glycoproteomic data, incorporating information from recent N- and O-glycoproteome studies on human and animal cell lines and some organs and body fluids. The initial data comprises sites of glycosylation for N-linked, O-GalNAc, O-Fucose, O-Xyl, O-Mannose (in both human and yeast) and cytosolic O-GlcNAc type. The data made available via this tool will be regularly updated to improve the coverage of known glycosylation sites and datasets, reflecting the advances currently being made in characterization of glycoproteomes. The tool is available at https://glycodomain.glycomics.ku.dk.

KW - Journal Article

U2 - 10.1093/glycob/cwx104

DO - 10.1093/glycob/cwx104

M3 - Journal article

C2 - 29267884

SN - 0959-6658

VL - 28

SP - 131

EP - 136

JO - Glycobiology

JF - Glycobiology

IS - 3

ER -