Glycine‐modified growth hormone secretagogues identified in seized doping material

Paulina Marta Gajda; Niels Bjerre Holm; Lars Jakobsen Hoej; Brian Schou Rasmussen; Petur Weihe Dalsgaard; Lotte Ask Reitzel; Kristian Linnet

doi:10.1002/dta.2489

Glycine‐modified growth hormone secretagogues identified in seized doping material

Paulina Marta Gajda, Niels Bjerre Holm, Lars Jakobsen Hoej, Brian Schou Rasmussen, Petur Weihe Dalsgaard^*, Lotte Ask Reitzel, Kristian Linnet

^*Corresponding author for this work

Section of Forensic Chemistry

6 Citations (Scopus)

Abstract

A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.

Original language	English
Journal	Drug Testing and Analysis
Volume	11
Issue number	2
Pages (from-to)	350-354
ISSN	1942-7603
DOIs	https://doi.org/10.1002/dta.2489
Publication status	Published - 1 Feb 2019

Keywords

doping
growth hormone secretagogues
LC–MS
modified GRF 1–29
Peptide hormones

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10.1002/dta.2489

Cite this

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abstract = "A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.",

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AU - Gajda, Paulina Marta

AU - Holm, Niels Bjerre

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AU - Dalsgaard, Petur Weihe

AU - Reitzel, Lotte Ask

AU - Linnet, Kristian

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AB - A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.

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Glycine‐modified growth hormone secretagogues identified in seized doping material

Abstract

Keywords

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