Glucose transporter 1 localisation throughout pregnancy in the carnivore placenta: light and electron microscope studies

TY - JOUR

T1 - Glucose transporter 1 localisation throughout pregnancy in the carnivore placenta

T2 - light and electron microscope studies

AU - Wooding, F.B.P.

AU - Dantzer, Vibeke

AU - Klisch, K.

AU - Jones, C.J.

AU - Forhead, A.J.

PY - 2007

Y1 - 2007

N2 - Glucose is one of the major fetal nutrients. Maternofetal transfer requires transport across the several placental membranes. This transfer is mediated by one or more of the fourteen known isoforms of glucose transporter. So far only Glucose Transporters 1 and 3 (GT1, GT3) have been shown to be located in placental membranes. GT1 may be the only one on the syncytiotrophoblast (human) or both may be present on the same membrane (rodents) or be required in sequence (ruminants, horses and elephant). This paper shows GT1 to be the only transporter demonstrable by immunocytochemistry in carnivore (cat, dog and mink) endotheliochorial placental membranes. GT1 is invariably present on both apical and basal surfaces of the cyto- and syncytiotrophoblast in all carnivore species examined and the pattern of development is described from implantation to term.

AB - Glucose is one of the major fetal nutrients. Maternofetal transfer requires transport across the several placental membranes. This transfer is mediated by one or more of the fourteen known isoforms of glucose transporter. So far only Glucose Transporters 1 and 3 (GT1, GT3) have been shown to be located in placental membranes. GT1 may be the only one on the syncytiotrophoblast (human) or both may be present on the same membrane (rodents) or be required in sequence (ruminants, horses and elephant). This paper shows GT1 to be the only transporter demonstrable by immunocytochemistry in carnivore (cat, dog and mink) endotheliochorial placental membranes. GT1 is invariably present on both apical and basal surfaces of the cyto- and syncytiotrophoblast in all carnivore species examined and the pattern of development is described from implantation to term.

KW - Former LIFE faculty

KW - Glucose transporters

KW - Placenta

KW - Immunocytochemistry

KW - Electron microscopy

KW - Carnivore

U2 - 10.1016/j.placenta.2006.07.006

DO - 10.1016/j.placenta.2006.07.006

M3 - Journal article

C2 - 17027079

SN - 0143-4004

VL - 28

SP - 453

EP - 464

JO - Placenta

JF - Placenta

IS - 5-6

ER -