Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study

Shala G. Berntsson; Ryan T. Merrell; E. Susan Amirian; Georgina N. Armstrong; Daniel Lachance; Anja Smits; Renke Zhou; Daniel I. Jacobs; Margaret R. Wrensch; Sara H. Olson; Dora Il’yasova; Elizabeth B. Claus; Jill S. Barnholtz-Sloan; Joellen Schildkraut; Siegal Sadetzki; Christoffer Johansen; Richard S. Houlston; Robert B. Jenkins; Jonine L. Bernstein; Rose Lai; Sanjay Shete; Christopher I. Amos; Melissa L. Bondy; Beatrice S. Melin

doi:10.1007/s00415-018-8857-0

Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study

Shala G. Berntsson^*, Ryan T. Merrell, E. Susan Amirian, Georgina N. Armstrong, Daniel Lachance, Anja Smits, Renke Zhou, Daniel I. Jacobs, Margaret R. Wrensch, Sara H. Olson, Dora Il’yasova, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Joellen Schildkraut, Siegal Sadetzki, Christoffer Johansen, Richard S. Houlston, Robert B. Jenkins, Jonine L. Bernstein, Rose LaiSanjay Shete, Christopher I. Amos, Melissa L. Bondy, Beatrice S. Melin

^*Corresponding author for this work

Department of Clinical Medicine

16 Citations (Scopus)

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Abstract

Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor for developing glioma-related seizures or glioma.

Original language	English
Journal	Journal of Neurology
Volume	265
Issue number	6
Pages (from-to)	1432-1442
Number of pages	11
ISSN	0340-5354
DOIs	https://doi.org/10.1007/s00415-018-8857-0
Publication status	Published - 2018

Keywords

Epileptic seizures
Glioma-related seizures
Observational study (cohort, case–control)
Primary brain tumor

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Berntsson, S. G., Merrell, R. T., Amirian, E. S., Armstrong, G. N., Lachance, D., Smits, A., Zhou, R., Jacobs, D. I., Wrensch, M. R., Olson, S. H., Il’yasova, D., Claus, E. B., Barnholtz-Sloan, J. S., Schildkraut, J., Sadetzki, S., Johansen, C., Houlston, R. S., Jenkins, R. B., Bernstein, J. L., ... Melin, B. S. (2018). Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study. Journal of Neurology, 265(6), 1432-1442. https://doi.org/10.1007/s00415-018-8857-0

Berntsson, SG, Merrell, RT, Amirian, ES, Armstrong, GN, Lachance, D, Smits, A, Zhou, R, Jacobs, DI, Wrensch, MR, Olson, SH, Il’yasova, D, Claus, EB, Barnholtz-Sloan, JS, Schildkraut, J, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Bernstein, JL, Lai, R, Shete, S, Amos, CI, Bondy, ML & Melin, BS 2018, 'Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study', Journal of Neurology, vol. 265, no. 6, pp. 1432-1442. https://doi.org/10.1007/s00415-018-8857-0

@article{0c7d4cfb45914a84af2dedebdf63909f,

title = "Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study",

abstract = "Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor for developing glioma-related seizures or glioma.",

keywords = "Epileptic seizures, Glioma-related seizures, Observational study (cohort, case–control), Primary brain tumor",

author = "Berntsson, {Shala G.} and Merrell, {Ryan T.} and Amirian, {E. Susan} and Armstrong, {Georgina N.} and Daniel Lachance and Anja Smits and Renke Zhou and Jacobs, {Daniel I.} and Wrensch, {Margaret R.} and Olson, {Sara H.} and Dora Il{\textquoteright}yasova and Claus, {Elizabeth B.} and Barnholtz-Sloan, {Jill S.} and Joellen Schildkraut and Siegal Sadetzki and Christoffer Johansen and Houlston, {Richard S.} and Jenkins, {Robert B.} and Bernstein, {Jonine L.} and Rose Lai and Sanjay Shete and Amos, {Christopher I.} and Bondy, {Melissa L.} and Melin, {Beatrice S.}",

year = "2018",

doi = "10.1007/s00415-018-8857-0",

language = "English",

volume = "265",

pages = "1432--1442",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "Springer Medizin",

number = "6",

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TY - JOUR

T1 - Glioma-related seizures in relation to histopathological subtypes

T2 - a report from the glioma international case–control study

AU - Berntsson, Shala G.

AU - Merrell, Ryan T.

AU - Amirian, E. Susan

AU - Armstrong, Georgina N.

AU - Lachance, Daniel

AU - Smits, Anja

AU - Zhou, Renke

AU - Jacobs, Daniel I.

AU - Wrensch, Margaret R.

AU - Olson, Sara H.

AU - Il’yasova, Dora

AU - Claus, Elizabeth B.

AU - Barnholtz-Sloan, Jill S.

AU - Schildkraut, Joellen

AU - Sadetzki, Siegal

AU - Johansen, Christoffer

AU - Houlston, Richard S.

AU - Jenkins, Robert B.

AU - Bernstein, Jonine L.

AU - Lai, Rose

AU - Shete, Sanjay

AU - Amos, Christopher I.

AU - Bondy, Melissa L.

AU - Melin, Beatrice S.

PY - 2018

Y1 - 2018

N2 - Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor for developing glioma-related seizures or glioma.

AB - Background: The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient characteristics, and to compare seizure history preceding tumor diagnosis (or study enrollment) between glioma patients and healthy controls. Methods: The Glioma International Case Control study (GICC) risk factor questionnaire collected information on demographics, past medical/medication history, and occupational history. Cases from eight centers were also asked detailed questions on seizures in relation to glioma diagnosis; cases (n = 4533) and controls (n = 4171) were also asked about seizures less than 2 years from diagnosis and previous seizure history more than 2 years prior to tumor diagnosis, including childhood seizures. Results: Low-grade gliomas (LGGs), particularly oligodendrogliomas/oligoastrocytomas, had the highest proportion of glioma-related seizures. Patients with low-grade astrocytoma demonstrated the most medically refractory seizures. A total of 83% of patients were using only one antiepileptic drug (AED), which was levetiracetam in 71% of cases. Gross total resection was strongly associated with reduced seizure frequency (p < 0.009). No significant difference was found between glioma cases and controls in terms of seizure occurring more than 2 years before diagnosis or during childhood. Conclusions: Our study showed that glioma-related seizures were most common in low-grade gliomas. Gross total resection was associated with lower seizure frequency. Additionally, having a history of childhood seizures is not a risk factor for developing glioma-related seizures or glioma.

KW - Epileptic seizures

KW - Glioma-related seizures

KW - Observational study (cohort, case–control)

KW - Primary brain tumor

U2 - 10.1007/s00415-018-8857-0

DO - 10.1007/s00415-018-8857-0

M3 - Journal article

C2 - 29687214

AN - SCOPUS:85045844511

SN - 0340-5354

VL - 265

SP - 1432

EP - 1442

JO - Journal of Neurology

JF - Journal of Neurology

IS - 6

ER -

Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case–control study

Abstract

Keywords

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