Glial and neuronal control of brain blood flow

TY - JOUR

T1 - Glial and neuronal control of brain blood flow

AU - Attwell, David

AU - Buchan, Alastair M

AU - Charpak, Serge

AU - Lauritzen, Martin

AU - Macvicar, Brian A

AU - Newman, Eric A

PY - 2010/11/11

Y1 - 2010/11/11

N2 - Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

AB - Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

U2 - http://dx.doi.org/10.1038/nature09613

DO - http://dx.doi.org/10.1038/nature09613

M3 - Journal article

SN - 0028-0836

VL - 468

SP - 232

EP - 243

JO - Nature

JF - Nature

IS - 7321

ER -