Giant glial cell: new insight through mechanism-based modeling

D E Postnov; L S Ryazanova; Nadezda Brazhe; Alexey Brazhe; G V Maximov; Erik Mosekilde; Olga Sosnovtseva

doi:10.1007/s10867-008-9070-7

Giant glial cell: new insight through mechanism-based modeling

D E Postnov, L S Ryazanova, Nadezda Brazhe, Alexey Brazhe, G V Maximov, Erik Mosekilde, Olga Sosnovtseva

Renal and Vascular Research

15 Citations (Scopus)

Abstract

The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.

Original language	English
Journal	Journal of Biological Physics
Volume	34
Issue number	3-4
Pages (from-to)	441-57
Number of pages	17
ISSN	0092-0606
DOIs	https://doi.org/10.1007/s10867-008-9070-7
Publication status	Published - 1 Aug 2008

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title = "Giant glial cell: new insight through mechanism-based modeling",

abstract = "The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.",

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T1 - Giant glial cell: new insight through mechanism-based modeling

AU - Postnov, D E

AU - Ryazanova, L S

AU - Brazhe, Nadezda

AU - Brazhe, Alexey

AU - Maximov, G V

AU - Mosekilde, Erik

AU - Sosnovtseva, Olga

PY - 2008/8/1

Y1 - 2008/8/1

N2 - The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.

AB - The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP(3) production and Ca(2 +) release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca(2 +) channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.

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DO - 10.1007/s10867-008-9070-7

M3 - Journal article

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SN - 0092-0606

VL - 34

SP - 441

EP - 457

JO - Journal of Biological Physics

JF - Journal of Biological Physics

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Giant glial cell: new insight through mechanism-based modeling

Abstract

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