Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism?

John M Hutson; Ruili Li; Bridget R Southwell; Bodil L Petersen; Jørgen Mogens Thorup; Dina Cortes

doi:10.3389/fendo.2012.00176

Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism?

John M Hutson, Ruili Li, Bridget R Southwell, Bodil L Petersen, Jørgen Mogens Thorup, Dina Cortes

64 Citations (Scopus)

Abstract

To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy.

Original language	English
Journal	Frontiers in Endocrinology
Volume	3
Pages (from-to)	176
ISSN	1664-2392
DOIs	https://doi.org/10.3389/fendo.2012.00176
Publication status	Published - 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3389/fendo.2012.00176

Cite this

@article{fee0af02a92f4073bb7afa05ba56773e,

title = "Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism?",

abstract = "To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy.",

author = "Hutson, {John M} and Ruili Li and Southwell, {Bridget R} and Petersen, {Bodil L} and Thorup, {J{\o}rgen Mogens} and Dina Cortes",

year = "2013",

doi = "10.3389/fendo.2012.00176",

language = "English",

volume = "3",

pages = "176",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Germ cell development in the postnatal testis

T2 - the key to prevent malignancy in cryptorchidism?

AU - Hutson, John M

AU - Li, Ruili

AU - Southwell, Bridget R

AU - Petersen, Bodil L

AU - Thorup, Jørgen Mogens

AU - Cortes, Dina

PY - 2013

Y1 - 2013

N2 - To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy.

AB - To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy.

U2 - 10.3389/fendo.2012.00176

DO - 10.3389/fendo.2012.00176

M3 - Journal article

C2 - 23316184

SN - 1664-2392

VL - 3

SP - 176

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

ER -

Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism?

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this