Genomic affinities of two 7,000-year-old Iberian hunter-gatherers

Federico Sánchez-Quinto; Hannes Schroeder; Oscar Ramirez; Maria del Carmen Avila Arcos; Marc Pybus; Iñigo Olalde; Amhed M. V. Velazquez; María Encina Prada Marcos; Julio Manuel Vidal Encinas; Jaume Bertranpetit; Ludovic Antoine Alexandre Orlando; Tom Gilbert; Carles Lalueza-Fox

doi:10.1016/j.cub.2012.06.005

Genomic affinities of two 7,000-year-old Iberian hunter-gatherers

Federico Sánchez-Quinto, Hannes Schroeder, Oscar Ramirez, Maria del Carmen Avila Arcos, Marc Pybus, Iñigo Olalde, Amhed M. V. Velazquez, María Encina Prada Marcos, Julio Manuel Vidal Encinas, Jaume Bertranpetit, Ludovic Antoine Alexandre Orlando, Tom Gilbert, Carles Lalueza-Fox

109 Citations (Scopus)

Abstract

The genetic background of the European Mesolithic and the extent of population replacement during the Neolithic [1-10] is poorly understood, both due to the scarcity of human remains from that period [11-18] and the inherent methodological difficulties of ancient DNA research. However, advances in sequencing technologies are both increasing data yields and providing supporting evidence for data authenticity, such as nucleotide misincorporation patterns [19-22]. We use these methods to characterize both the mitochondrial DNA genome and generate shotgun genomic data from two exceptionally well-preserved 7,000-year-old Mesolithic individuals from La Braña-Arintero site in León (Northwestern Spain) [23]. The mitochondria of both individuals are assigned to U5b2c1, a haplotype common among the small number of other previously studied Mesolithic individuals from Northern and Central Europe. This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations. Using Approximate Bayesian Computation, a model of genetic continuity from Mesolithic to Neolithic populations is poorly supported. Furthermore, analyses of 1.34% and 0.53% of their nuclear genomes, containing about 50,000 and 20,000 ancestry informative SNPs, respectively, show that these two Mesolithic individuals are not related to current populations from either the Iberian Peninsula or Southern Europe.

Original language	English
Journal	Current Biology
Volume	22
Issue number	16
Pages (from-to)	1494-1499
Number of pages	6
ISSN	0960-9822
DOIs	https://doi.org/10.1016/j.cub.2012.06.005
Publication status	Published - 21 Aug 2012

Keywords

biology

Access to Document

10.1016/j.cub.2012.06.005

http://www.cell.com/article/S0960982212006501/pdf

Cite this

@article{a1f1457ad1f4442797c383016caa3d71,

title = "Genomic affinities of two 7,000-year-old Iberian hunter-gatherers",

abstract = "The genetic background of the European Mesolithic and the extent of population replacement during the Neolithic [1-10] is poorly understood, both due to the scarcity of human remains from that period [11-18] and the inherent methodological difficulties of ancient DNA research. However, advances in sequencing technologies are both increasing data yields and providing supporting evidence for data authenticity, such as nucleotide misincorporation patterns [19-22]. We use these methods to characterize both the mitochondrial DNA genome and generate shotgun genomic data from two exceptionally well-preserved 7,000-year-old Mesolithic individuals from La Bra{\~n}a-Arintero site in Le{\'o}n (Northwestern Spain) [23]. The mitochondria of both individuals are assigned to U5b2c1, a haplotype common among the small number of other previously studied Mesolithic individuals from Northern and Central Europe. This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations. Using Approximate Bayesian Computation, a model of genetic continuity from Mesolithic to Neolithic populations is poorly supported. Furthermore, analyses of 1.34% and 0.53% of their nuclear genomes, containing about 50,000 and 20,000 ancestry informative SNPs, respectively, show that these two Mesolithic individuals are not related to current populations from either the Iberian Peninsula or Southern Europe.",

keywords = "biology",

author = "Federico S{\'a}nchez-Quinto and Hannes Schroeder and Oscar Ramirez and {Avila Arcos}, {Maria del Carmen} and Marc Pybus and I{\~n}igo Olalde and Velazquez, {Amhed M. V.} and Mar{\'i}a Encina Prada Marcos and Julio Manuel Vidal Encinas and Jaume Bertranpetit and Orlando, {Ludovic Antoine Alexandre} and Tom Gilbert and Carles Lalueza-Fox",

year = "2012",

month = aug,

day = "21",

doi = "10.1016/j.cub.2012.06.005",

language = "English",

volume = "22",

pages = "1494--1499",

journal = "Current Biology",

issn = "0960-9822",

publisher = "Cell Press",

number = "16",

}

TY - JOUR

T1 - Genomic affinities of two 7,000-year-old Iberian hunter-gatherers

AU - Sánchez-Quinto, Federico

AU - Schroeder, Hannes

AU - Ramirez, Oscar

AU - Avila Arcos, Maria del Carmen

AU - Pybus, Marc

AU - Olalde, Iñigo

AU - Velazquez, Amhed M. V.

AU - Marcos, María Encina Prada

AU - Encinas, Julio Manuel Vidal

AU - Bertranpetit, Jaume

AU - Orlando, Ludovic Antoine Alexandre

AU - Gilbert, Tom

AU - Lalueza-Fox, Carles

PY - 2012/8/21

Y1 - 2012/8/21

N2 - The genetic background of the European Mesolithic and the extent of population replacement during the Neolithic [1-10] is poorly understood, both due to the scarcity of human remains from that period [11-18] and the inherent methodological difficulties of ancient DNA research. However, advances in sequencing technologies are both increasing data yields and providing supporting evidence for data authenticity, such as nucleotide misincorporation patterns [19-22]. We use these methods to characterize both the mitochondrial DNA genome and generate shotgun genomic data from two exceptionally well-preserved 7,000-year-old Mesolithic individuals from La Braña-Arintero site in León (Northwestern Spain) [23]. The mitochondria of both individuals are assigned to U5b2c1, a haplotype common among the small number of other previously studied Mesolithic individuals from Northern and Central Europe. This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations. Using Approximate Bayesian Computation, a model of genetic continuity from Mesolithic to Neolithic populations is poorly supported. Furthermore, analyses of 1.34% and 0.53% of their nuclear genomes, containing about 50,000 and 20,000 ancestry informative SNPs, respectively, show that these two Mesolithic individuals are not related to current populations from either the Iberian Peninsula or Southern Europe.

AB - The genetic background of the European Mesolithic and the extent of population replacement during the Neolithic [1-10] is poorly understood, both due to the scarcity of human remains from that period [11-18] and the inherent methodological difficulties of ancient DNA research. However, advances in sequencing technologies are both increasing data yields and providing supporting evidence for data authenticity, such as nucleotide misincorporation patterns [19-22]. We use these methods to characterize both the mitochondrial DNA genome and generate shotgun genomic data from two exceptionally well-preserved 7,000-year-old Mesolithic individuals from La Braña-Arintero site in León (Northwestern Spain) [23]. The mitochondria of both individuals are assigned to U5b2c1, a haplotype common among the small number of other previously studied Mesolithic individuals from Northern and Central Europe. This suggests a remarkable genetic uniformity and little phylogeographic structure over a large geographic area of the pre-Neolithic populations. Using Approximate Bayesian Computation, a model of genetic continuity from Mesolithic to Neolithic populations is poorly supported. Furthermore, analyses of 1.34% and 0.53% of their nuclear genomes, containing about 50,000 and 20,000 ancestry informative SNPs, respectively, show that these two Mesolithic individuals are not related to current populations from either the Iberian Peninsula or Southern Europe.

KW - biology

U2 - 10.1016/j.cub.2012.06.005

DO - 10.1016/j.cub.2012.06.005

M3 - Journal article

C2 - 22748318

SN - 0960-9822

VL - 22

SP - 1494

EP - 1499

JO - Current Biology

JF - Current Biology

IS - 16

ER -

Genomic affinities of two 7,000-year-old Iberian hunter-gatherers

Abstract

Keywords

Access to Document

Fingerprint

Cite this