Genome-wide screens for expressed hypothetical proteins

Claus Desler Madsen; Jon Ambæk Durhuus; Lene Juel Rasmussen

doi:10.1007/978-1-61779-424-7_3

Genome-wide screens for expressed hypothetical proteins

Claus Desler Madsen, Jon Ambæk Durhuus, Lene Juel Rasmussen

6 Citations (Scopus)

Abstract

A hypothetical protein (HP) is defined as a protein that is predicted to be expressed from an open reading frame, but for which there is no experimental evidence of translation. HPs constitute a substantial fraction of proteomes of human as well as of other organisms. With the general belief that the majority of HPs are the product of pseudogenes, it is essential to have a tool with the ability of pinpointing the minority of HPs with a high probability of being expressed.

Original language	English
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	815
Pages (from-to)	25-38
Number of pages	14
DOIs	https://doi.org/10.1007/978-1-61779-424-7_3
Publication status	Published - 2012

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abstract = "A hypothetical protein (HP) is defined as a protein that is predicted to be expressed from an open reading frame, but for which there is no experimental evidence of translation. HPs constitute a substantial fraction of proteomes of human as well as of other organisms. With the general belief that the majority of HPs are the product of pseudogenes, it is essential to have a tool with the ability of pinpointing the minority of HPs with a high probability of being expressed.",

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AU - Rasmussen, Lene Juel

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AB - A hypothetical protein (HP) is defined as a protein that is predicted to be expressed from an open reading frame, but for which there is no experimental evidence of translation. HPs constitute a substantial fraction of proteomes of human as well as of other organisms. With the general belief that the majority of HPs are the product of pseudogenes, it is essential to have a tool with the ability of pinpointing the minority of HPs with a high probability of being expressed.

U2 - 10.1007/978-1-61779-424-7_3

DO - 10.1007/978-1-61779-424-7_3

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C2 - 22130981

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JO - Methods in molecular biology (Clifton, N.J.)

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Genome-wide screens for expressed hypothetical proteins

Abstract

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