Genome-wide identification of quantitative trait loci in a cross between Hampshire and Landrace II: meat quality traits

TY - JOUR

T1 - Genome-wide identification of quantitative trait loci in a cross between Hampshire and Landrace II

T2 - meat quality traits

AU - Markljung, Ellen

AU - Braunschweig, Martin H.

AU - Karlskov-Mortensen, Peter

AU - Bruun, Camilla Vibeke Sichlau

AU - Sawera, Milena

AU - Cho, In-Cheol

AU - Hedebro-Velander, Ingela

AU - Josell, Åsa

AU - Lundström, Kerstin

AU - Seth, Gertrud von

AU - Jørgensen, Claus Bøttcher

AU - Fredholm, Merete

AU - Andersson, Leif

PY - 2008

Y1 - 2008

N2 - Background: Meat quality traits are important in pig breeding programs, but they are difficult to include in a traditional selection program. Marker assisted selection (MAS) of meat quality traits is therefore of interest in breeding programs and a Quantitative Trait Locus (QTL) analysis is the key to identifying markers that can be used in MAS. In this study, Landrace and Hampshire intercross and backcross families were used to investigate meat quality traits. Hampshire pigs are commonly used as sthe sire line in commercial pig breeding. This is the first time a pedigree including Hampshire pigs has been used for a QTL analysis of meat quality traits.Results: In total, we analyzed 39 meat quality traits and identified eight genome-wide significant QTL peaks in four regions: one on chromosome 3, two on chromosome 6 and one on chromosome 16. At least two of the QTLs do not appear to have been detected inprevious studies. On chromosome 6 we identified QTLs for water content in M. longissimus dorsi (LD)), drip loss in LD and post mortem pH decline in LD. On chromosomes 3 and 16 we identified previously undetected QTLs for protein content in LD and for freezing and cooking loss respectively.Conclusion: We identified at least two new meat quality trait QTLs at the genome-wide significance level. We detected two QTLs on chromosome 6 that possibly coincide with QTLs detected in other studies. We were also able to exclude the C1843T mutation in the ryanodine receptor (RYRI) as a causative mutation for one of the chromosome 6 QTLs in this cross.

AB - Background: Meat quality traits are important in pig breeding programs, but they are difficult to include in a traditional selection program. Marker assisted selection (MAS) of meat quality traits is therefore of interest in breeding programs and a Quantitative Trait Locus (QTL) analysis is the key to identifying markers that can be used in MAS. In this study, Landrace and Hampshire intercross and backcross families were used to investigate meat quality traits. Hampshire pigs are commonly used as sthe sire line in commercial pig breeding. This is the first time a pedigree including Hampshire pigs has been used for a QTL analysis of meat quality traits.Results: In total, we analyzed 39 meat quality traits and identified eight genome-wide significant QTL peaks in four regions: one on chromosome 3, two on chromosome 6 and one on chromosome 16. At least two of the QTLs do not appear to have been detected inprevious studies. On chromosome 6 we identified QTLs for water content in M. longissimus dorsi (LD)), drip loss in LD and post mortem pH decline in LD. On chromosomes 3 and 16 we identified previously undetected QTLs for protein content in LD and for freezing and cooking loss respectively.Conclusion: We identified at least two new meat quality trait QTLs at the genome-wide significance level. We detected two QTLs on chromosome 6 that possibly coincide with QTLs detected in other studies. We were also able to exclude the C1843T mutation in the ryanodine receptor (RYRI) as a causative mutation for one of the chromosome 6 QTLs in this cross.

U2 - 10.1186/1471-2156-9-22

DO - 10.1186/1471-2156-9-22

M3 - Journal article

C2 - 18304368

SN - 1471-2156

VL - 9

JO - BMC Genetics

JF - BMC Genetics

IS - 22

ER -